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  • Douglas McFadden

Women in cardiology: The x factor and the heart of medicine

Lucas, A., Eaverly, M., McFadden, G. & Bryant, M., Feb 2014, In : Journal of Clinical and Experimental Cardiology. 5, 2

Research output: Contribution to journalEditorial

Viruses for tumor therapy

Bell, J. & McFadden, G., Mar 12 2014, In : Cell Host and Microbe. 15, 3, p. 260-265 6 p.

Research output: Contribution to journalReview article

78 Scopus citations

Virotherapy using Myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells

Bartee, E., Meacham, A., Wise, E., Cogle, C. R. & McFadden, G., Aug 14 2012, In : PloS one. 7, 8, e43298.

Research output: Contribution to journalArticle

11 Scopus citations

Viral serpin therapeutics: From concept to clinic

Chen, H., Zheng, D., Davids, J., Bartee, M. Y., Dai, E., Liu, L., Petrov, L., Macaulay, C., Thoburn, R., Sobel, E., Moyer, R., McFadden, D. & Lucas, A., Jun 24 2011, In : Methods in Enzymology. 499, p. 301-329 29 p.

Research output: Contribution to journalArticle

17 Scopus citations

Viral anti-inflammatory proteins target diverging immune pathways with converging effects on arterial dilatation, plaque and apoptosis

Davids, J. A., Dai, E., Chen, H., Bartee, M. Y., Liu, L., Fortunel, A., Moyer, R., Mcfadden, G. & Lucas, A. R., Jan 1 2014, In : European Journal of Inflammation. 12, 1, p. 131-145 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Vaccinia virus dissemination requires p21-activated kinase 1

Andrade, L. G., Albarnaz, J. D., Mügge, F. L. B., David, B. A., Abrahão, J. S., da Fonseca, F. G., Kroon, E. G., Menezes, G. B., McFadden, D. & Bonjardim, C. A., Nov 1 2016, In : Archives of Virology. 161, 11, p. 2991-3002 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Tumor necrosis factor inhibitors from poxviruses with an emphasis on tanapoxvirus-2L protein

Jeng, D., Rahman, M. M., McFadden, G. & Essani, K., Aug 1 2011, In : Recent Patents on DNA and Gene Sequences. 5, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin

Zemp, F. J., Lun, X., McKenzie, B. A., Zhou, H., Maxwell, L., Sun, B., Kelly, J. J. P., Stechishin, O., Luchman, A., Weiss, S., Cairncross, J. G., Hamilton, M. G., Rabinovich, B. A., Rahman, M. M., Mohamed, M. R., Smallwood, S., Senger, D. L., Bell, J., McFadden, G. & Forsyth, P. A., Jul 2013, In : Neuro-Oncology. 15, 7, p. 904-920 17 p.

Research output: Contribution to journalArticle

24 Scopus citations

The virome: Viral ghost companion, virus wars

Lucas, A., Ambadapadi, S., Zheng, D., Chen, H., Lakshmyya, K., Progulske-Fox, A., Krafft, A., Bryant, M., O’Regan, S., Moyer, R., McFadden, G., Jobin, C. & Rand, K., Jan 1 2014, In : Journal of Clinical and Experimental Cardiology. 5, 8, e136.

Research output: Contribution to journalEditorial

1 Scopus citations

The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells

Jeng, D., Ma, Z., Barrett, J. W., McFadden, G., Loeb, J. A. & Essania, K., Mar 2013, In : Journal of virology. 87, 6, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation

Chen, H., Davids, J. A., Zheng, D., Bryant, M., Bot, I., van Berckel, T. J. C., Biessen, E., Pepine, C., Ryman, K., Progulski-Fox, A., Kesavalu, L., Moyer, R., McFadden, G. & Lucas, A., Jan 1 2013, In : Cardiovascular and Hematological Disorders - Drug Targets. 13, 2, p. 99-110 12 p.

Research output: Contribution to journalReview article

10 Scopus citations

Therapeutics for graft-versus-host disease: From conventional therapies to novel virotherapeutic strategies

Villa, N. Y., Rahman, M. M., McFadden, G. & Cogle, C. R., Mar 2016, In : Viruses. 8, 3, 85.

Research output: Contribution to journalReview article

4 Scopus citations

The poxvirus C7L host range factor superfamily

Liu, J., Rothenburg, S. & McFadden, G., Dec 2012, In : Current opinion in virology. 2, 6, p. 764-772 9 p.

Research output: Contribution to journalReview article

11 Scopus citations

The current status and future directions of myxoma virus, a master in immune evasion

Spiesschaert, B., McFadden, G., Hermans, K., Nauwynck, H. & Van De Walle, G. R., 2011, In : Veterinary Research. 42, 1, 76.

Research output: Contribution to journalReview article

28 Scopus citations

Targeting gallbladder cancer: Oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo

Weng, M., Gong, W., Ma, M., Chu, B., Qin, Y., Zhang, M., Lun, X., McFadden, G., Forsyth, P., Yang, Y. & Quan, Z., Apr 13 2014, In : Molecular Cancer. 13, 1, 82.

Research output: Contribution to journalArticle

12 Scopus citations

Tanapox virus

Barrett, J. W. & McFadden, D., Apr 19 2016, Molecular Detection of Human Viral Pathogens. CRC Press, p. 1039-1046 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma

Tang, B., Guo, Z. S., Bartlett, D. L., Yan, D. Z., Schane, C. P., Thomas, D. L., Liu, J., McFadden, G., Shisler, J. L., Roy, E. J. & Roy, E. J., May 1 2020, In : Clinical Cancer Research. 26, 9, p. 2216-2230 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus

Brahn, E., Lee, S., Lucas, A., McFadden, G. & MaCaulay, C., Aug 2014, In : Clinical Immunology. 153, 2, p. 254-263 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplantation Grafts using Oncolytic Myxoma Virus

Bartee, E., Chan, W. M., Moreb, J. S., Cogle, C. R. & McFadden, G., Oct 2012, In : Biology of Blood and Marrow Transplantation. 18, 10, p. 1540-1551 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Scalable collaborative infrastructure for a learning healthcare system (SCILHS): Architecture

Mandl, K. D., Kohane, I. S., McFadden, D., Weber, G. M., Natter, M., Mandel, J., Schneeweiss, S., Weiler, S., Klann, J. G., Bickel, J., Adams, W. G., Ge, Y., Zhou, X., Perkins, J., Marsolo, K., Berns tam, E., Showalter, J., Quarshie, A., Ofili, E., Hripcsak, G. & 1 others, Murphy, S. N., 2014, In : Journal of the American Medical Informatics Association. 21, 4, p. 615-620 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Resistance to Oncolytic Myxoma Virus Therapy in Nf1-/-/Trp53-/- Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

Zemp, F. J., McKenzie, B. A., Lun, X., Maxwell, L., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Jun 6 2013, In : PloS one. 8, 6, e65801.

Research output: Contribution to journalArticle

10 Scopus citations
7 Scopus citations

Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies

van Vloten, J. P., Santry, L. A., McAusland, T. M., Karimi, K., McFadden, D., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Jun 14 2019, In : Molecular Therapy - Methods and Clinical Development. 13, p. 154-166 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Quantifying Antibody Responses Induced by Antigen-Agnostic Immunotherapies

van Vloten, J. P., Klafuric, E. M., Karimi, K., McFadden, G., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Sep 13 2019, In : Molecular Therapy - Methods and Clinical Development. 14, p. 189-196 8 p.

Research output: Contribution to journalArticle

Open Access

Production of myxoma virus gateway entry and expression libraries and validation of viral protein expression

Smallwood, S. E., Rahman, M. M., Werden, S. J., Martino, M. F. & McFadden, G., 2011, In : Current Protocols in Microbiology. SUPPL.21

Research output: Contribution to journalArticle

2 Scopus citations

Poxvirus oncolytic virotherapy

Torres-Domínguez, L. E. & McFadden, G., Jun 3 2019, In : Expert Opinion on Biological Therapy. 19, 6, p. 561-573 13 p.

Research output: Contribution to journalReview article

6 Scopus citations

Poxviruses and the evolution of host range and virulence

Haller, S. L., Peng, C., McFadden, G. & Rothenburg, S., Jan 2014, In : Infection, Genetics and Evolution. 21, p. 15-40 26 p.

Research output: Contribution to journalReview article

85 Scopus citations

Positive evolutionary selection on the RIG-I-like receptor genes in mammals

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Nov 27 2013, In : PloS one. 8, 11, e81864.

Research output: Contribution to journalArticle

21 Scopus citations

Parallel adaptation of rabbit populations to myxoma virus

Alves, J. M., Carneiro, M., Cheng, J. Y., de Matos, A. L., Rahman, M., Loog, L., Campos, P. F., Wales, N., Eriksson, A., Manica, A., Strive, T., Graham, S. C., Afonso, S., Bell, D. J., Belmont, L., Day, J. P., Fuller, S. J., Marchandeau, S., Palmer, W. J., Queney, G. & 9 others, Surridge, A. K., Vieira, F. G., McFadden, D., Nielsen, R., Thomas, M., Gilbert, P., Esteves, P. J., Ferrand, N. & Jiggins, F. M., Mar 22 2019, In : Science. 363, 6433, p. 1319-1326 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Oncolytic Viruses and the Immune System: The Dynamic Duo

Lemos de Matos, A., Franco, L. S. & McFadden, G., Jun 12 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 349-358 10 p.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival

Kellish, P., Shabashvili, D., Rahman, M. M., Nawab, A., Guijarro, M. V., Zhang, M., Cao, C., Moussatche, N., Boyle, T., Antonia, S., Reinhard, M., Hartzell, C., Jantz, M., Mehta, H. J., McFadden, G., Kaye, F. J. & Zajac-Kaye, M., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2279-2292 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Oncolytic virotherapy for pancreatic cancer.

Wennier, S., Li, S. & McFadden, G., 2011, In : Expert reviews in molecular medicine. 13, p. e18

Research output: Contribution to journalReview article

23 Scopus citations

Oncolytic virotherapy for hematological malignancies

Bais, S., Bartee, E., Rahman, M. M., McFadden, G. & Cogle, C. R., 2012, In : Advances in Virology. 2012, 186512.

Research output: Contribution to journalReview article

23 Scopus citations

Oncolytic poxviruses

Chan, W. M. & McFadden, G., Sep 29 2014, In : Annual Review of Virology. 1, 1, p. 191-214 24 p.

Research output: Contribution to journalArticle

52 Scopus citations

Oncolytic myxoma virus: The path to clinic

Chan, W. M., Rahman, M. M. & McFadden, G., Sep 6 2013, In : Vaccine. 31, 39, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps

Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G. & Kubes, P., Feb 13 2013, In : Cell Host and Microbe. 13, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

195 Scopus citations

Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer

Wennier, S. T., Liu, J., Li, S., Rahman, M. M., Mona, M. & McFadden, G., Apr 2012, In : Molecular Therapy. 20, 4, p. 759-768 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
31 Scopus citations

Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity

Correa, R. J. M., Komar, M., Tong, J. G. K., Sivapragasam, M., Rahman, M. M., McFadden, G., Dimattia, G. E. & Shepherd, T. G., May 2012, In : Gynecologic Oncology. 125, 2, p. 441-450 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
23 Scopus citations

Myxoma virus M064 Is a novel member of the poxvirus C7l superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits

Liu, J., Wennier, S., Moussatche, N., Reinhard, M., Condit, R. & McFadden, G., May 2012, In : Journal of virology. 86, 9, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs

Garg, R. R., Jackson, C. B., Rahman, M. M., Khan, A. R., Lewin, A. S. & McFadden, G., May 24 2019, In : Journal of Biological Chemistry. 294, 21, p. 8480-8489 10 p.

Research output: Contribution to journalArticle

Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma

Jazowiecka-Rakus, J., Sochanik, A., Rusin, A., Hadryś, A., Fidyk, W., Villa, N., Rahman, M. M., Chmielik, E., Franco, L. S. & McFadden, G., Sep 25 2020, In : Molecular Therapy - Oncolytics. 18, p. 335-350 16 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Myxoma Virus Infection Promotes NK Lysis of Malignant Gliomas In Vitro and In Vivo

Ogbomo, H., Zemp, F. J., Lun, X., Zhang, J., Stack, D., Rahman, M. M., Mcfadden, G., Mody, C. H. & Forsyth, P. A., Jun 10 2013, In : PloS one. 8, 6, e66825.

Research output: Contribution to journalArticle

25 Scopus citations

Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/Myd88-, IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Dec 2011, In : Journal of virology. 85, 23, p. 12835 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Myxoma virus induces type i interferon production in murine plasmacytoid dendritic cells via a TLR9/myd88-,IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Oct 2011, In : Journal of virology. 85, 20, p. 10814-10825 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PloS one. 9, 10, e109801.

Research output: Contribution to journalArticle

21 Scopus citations
Open Access

Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection

Chen, H., Zheng, D., Abbott, J., Liu, L., Bartee, M. Y., Long, M., Davids, J., Williams, J., Feldmann, H., Strong, J., Grau, K. R., Tibbetts, S., Macaulay, C., McFadden, G., Thoburn, R., Lomas, D. A., Spinale, F. G., Virgin, H. W. & Lucas, A., Sep 2013, In : Antimicrobial Agents and Chemotherapy. 57, 9, p. 4114-4127 14 p.

Research output: Contribution to journalArticle

20 Scopus citations