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  • Douglas McFadden
2020

Autologous Transplantation Using Donor Leukocytes Loaded Ex Vivo with Oncolytic Myxoma Virus Can Eliminate Residual Multiple Myeloma

Villa, N. Y., Rahman, M. M., Mamola, J., D'Isabella, J., Goras, E., Kilbourne, J., Lowe, K., Daggett-Vondras, J., Torres, L., Christie, J., Appel, N., Cox, A. L., Kim, J. B. & McFadden, G., Sep 25 2020, In : Molecular Therapy - Oncolytics. 18, p. 171-188 18 p.

Research output: Contribution to journalArticle

Open Access

Coinfections of novel polyomavirus, anelloviruses and a recombinant strain of myxoma virus-MYXV-tol identified in Iberian hares

Ägueda-Pinto, A., Kraberger, S., Lund, M. C., Gortázar, C., McFadden, G., Varsani, A. & Esteves, P. J., Jan 1 2020, In : Viruses. 12, 3, 340.

Research output: Contribution to journalArticle

Open Access

Ex Vivo Virotherapy with Myxoma Virus to Treat Cancer

Villa, N. Y., Franco, L. S. & McFadden, G., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 95-110 16 p. (Methods in Molecular Biology; vol. 2058).

Research output: Chapter in Book/Report/Conference proceedingChapter

Genome characterization of cetaceanpox virus from a managed Indo-Pacific bottlenose dolphin (Tursiops aduncus)

Rodrigues, T. C. S., Subramaniam, K., Varsani, A., McFadden, G., Schaefer, A. M., Bossart, G. D., Romero, C. H. & Waltzek, T. B., Mar 2020, In : Virus research. 278, 197861.

Research output: Contribution to journalArticle

Mesenchymal stem cells as carriers for systemic delivery of oncolytic viruses

Hadryś, A., Sochanik, A., McFadden, G. & Jazowiecka-Rakus, J., May 5 2020, In : European Journal of Pharmacology. 874, 172991.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations
Open Access

Oncolytic Viruses and the Immune System: The Dynamic Duo

Lemos de Matos, A., Franco, L. S. & McFadden, G., Jun 12 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 349-358 10 p.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma

Tang, B., Guo, Z. S., Bartlett, D. L., Yan, D. Z., Schane, C. P., Thomas, D. L., Liu, J., McFadden, G., Shisler, J. L., Roy, E. J. & Roy, E. J., May 1 2020, In : Clinical Cancer Research. 26, 9, p. 2216-2230 15 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Author Correction: The wide utility of rabbits as models of human diseases (Experimental & Molecular Medicine, (2018), 50, 5, (66), 10.1038/s12276-018-0094-1)

Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., González-Gallego, J., Giacani, L., Hu, J., Kaplan, G., Keppler, O. T., Knight, K. L., Kong, X. P., Lanning, D. K., Le Pendu, J., de Matos, A. L., Liu, J., Liu, S., Lopes, A. M., Lu, S. & 17 others, Lukehart, S., Manabe, Y. C., Neves, F., McFadden, G., Pan, R., Peng, X., de Sousa-Pereira, P., Pinheiro, A., Rahman, M., Ruvoën-Clouet, N., Subbian, S., Tuñón, M. J., van der Loo, W., Vaine, M., Via, L. E., Wang, S. & Mage, R., Jul 1 2019, In : Experimental and Molecular Medicine. 51, 7, 71.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Genetic characterization of a recombinant myxoma virus in the iberian hare (Lepus granatensis)

Águeda-Pinto, A., Matos, A. L. D., Abrantes, M., Kraberger, S., Risalde, M. A., Gortázar, C., McFadden, G., Varsani, A. & Esteves, P. J., Jun 2019, In : Viruses. 11, 6, 530.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?

Yaron, J. R., Kwiecien, J. M., Zhang, L., Ambadapadi, S., Wakefield, D. N., Clapp, W. L., Dabrowski, W., Burgin, M., Munk, B. H., McFadden, G., Chen, H. & Lucas, A. R., Jul 2019, In : Trends in Molecular Medicine. 25, 7, p. 626-639 14 p.

Research output: Contribution to journalReview article

Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs

Garg, R. R., Jackson, C. B., Rahman, M. M., Khan, A. R., Lewin, A. S. & McFadden, G., May 24 2019, In : Journal of Biological Chemistry. 294, 21, p. 8480-8489 10 p.

Research output: Contribution to journalArticle

Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival

Kellish, P., Shabashvili, D., Rahman, M. M., Nawab, A., Guijarro, M. V., Zhang, M., Cao, C., Moussatche, N., Boyle, T., Antonia, S., Reinhard, M., Hartzell, C., Jantz, M., Mehta, H. J., McFadden, G., Kaye, F. J. & Zajac-Kaye, M., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2279-2292 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Parallel adaptation of rabbit populations to myxoma virus

Alves, J. M., Carneiro, M., Cheng, J. Y., de Matos, A. L., Rahman, M., Loog, L., Campos, P. F., Wales, N., Eriksson, A., Manica, A., Strive, T., Graham, S. C., Afonso, S., Bell, D. J., Belmont, L., Day, J. P., Fuller, S. J., Marchandeau, S., Palmer, W. J., Queney, G. & 9 others, Surridge, A. K., Vieira, F. G., McFadden, D., Nielsen, R., Thomas, M., Gilbert, P., Esteves, P. J., Ferrand, N. & Jiggins, F. M., Mar 22 2019, In : Science. 363, 6433, p. 1319-1326 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Poxvirus oncolytic virotherapy

Torres-Domínguez, L. E. & McFadden, G., Jun 3 2019, In : Expert Opinion on Biological Therapy. 19, 6, p. 561-573 13 p.

Research output: Contribution to journalReview article

5 Scopus citations

Quantifying Antibody Responses Induced by Antigen-Agnostic Immunotherapies

van Vloten, J. P., Klafuric, E. M., Karimi, K., McFadden, G., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Sep 13 2019, In : Molecular Therapy - Methods and Clinical Development. 14, p. 189-196 8 p.

Research output: Contribution to journalArticle

Open Access

Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies

van Vloten, J. P., Santry, L. A., McAusland, T. M., Karimi, K., McFadden, D., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Jun 14 2019, In : Molecular Therapy - Methods and Clinical Development. 13, p. 154-166 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Ex vivo virotherapy with myxoma virus does not impair hematopoietic stem and progenitor cells

Villa, N., Bais, S., Chan, W. M., Meacham, A. M., Wise, E., Rahman, M., Moreb, J. S., Rosenau, E. H., Wingard, J. R., McFadden, D. & Cogle, C. R., Mar 1 2016, In : Cytotherapy. 18, 3, p. 465-480 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

Pisklakova, A., McKenzie, B., Zemp, F., Lun, X., Kenchappa, R. S., Etame, A. B., Rahman, M. M., Reilly, K., Pilon-Thomas, S., McFadden, G., Kurz, E. & Forsyth, P. A., Aug 1 2016, In : Neuro-Oncology. 18, 8, p. 1088-1098 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
23 Scopus citations

Tanapox virus

Barrett, J. W. & McFadden, D., Apr 19 2016, Molecular Detection of Human Viral Pathogens. CRC Press, p. 1039-1046 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Therapeutics for graft-versus-host disease: From conventional therapies to novel virotherapeutic strategies

Villa, N. Y., Rahman, M. M., McFadden, G. & Cogle, C. R., Mar 2016, In : Viruses. 8, 3, 85.

Research output: Contribution to journalReview article

4 Scopus citations

Vaccinia virus dissemination requires p21-activated kinase 1

Andrade, L. G., Albarnaz, J. D., Mügge, F. L. B., David, B. A., Abrahão, J. S., da Fonseca, F. G., Kroon, E. G., Menezes, G. B., McFadden, D. & Bonjardim, C. A., Nov 1 2016, In : Archives of Virology. 161, 11, p. 2991-3002 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Are We There Yet? The Smallpox Research Agenda Using Variola Virus

Damon, I. K., Damaso, C. R. & McFadden, G., May 2014, In : PLoS Pathogens. 10, 5, e1004108.

Research output: Contribution to journalArticle

14 Scopus citations

Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus

Zemp, F. J., McKenzie, B. A., Lun, X., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Dec 15 2014, In : Cancer Research. 74, 24, p. 7260-7273 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Jan 1 2014, In : Immunogenetics. 66, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PloS one. 9, 10, e109801.

Research output: Contribution to journalArticle

20 Scopus citations

Oncolytic poxviruses

Chan, W. M. & McFadden, D., Sep 29 2014, In : Annual Review of Virology. 1, 1, p. 191-214 24 p.

Research output: Contribution to journalArticle

51 Scopus citations

Poxviruses and the evolution of host range and virulence

Haller, S. L., Peng, C., McFadden, G. & Rothenburg, S., Jan 2014, In : Infection, Genetics and Evolution. 21, p. 15-40 26 p.

Research output: Contribution to journalReview article

82 Scopus citations
6 Scopus citations

Scalable collaborative infrastructure for a learning healthcare system (SCILHS): Architecture

Mandl, K. D., Kohane, I. S., McFadden, D., Weber, G. M., Natter, M., Mandel, J., Schneeweiss, S., Weiler, S., Klann, J. G., Bickel, J., Adams, W. G., Ge, Y., Zhou, X., Perkins, J., Marsolo, K., Berns tam, E., Showalter, J., Quarshie, A., Ofili, E., Hripcsak, G. & 1 others, Murphy, S. N., Jan 1 2014, In : Journal of the American Medical Informatics Association. 21, 4, p. 615-620 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus

Brahn, E., Lee, S., Lucas, A., McFadden, G. & MaCaulay, C., Aug 2014, In : Clinical Immunology. 153, 2, p. 254-263 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting gallbladder cancer: Oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo

Weng, M., Gong, W., Ma, M., Chu, B., Qin, Y., Zhang, M., Lun, X., McFadden, G., Forsyth, P., Yang, Y. & Quan, Z., Apr 13 2014, In : Molecular Cancer. 13, 1, 82.

Research output: Contribution to journalArticle

12 Scopus citations

The virome: Viral ghost companion, virus wars

Lucas, A., Ambadapadi, S., Zheng, D., Chen, H., Lakshmyya, K., Progulske-Fox, A., Krafft, A., Bryant, M., O’Regan, S., Moyer, R., McFadden, G., Jobin, C. & Rand, K., Jan 1 2014, In : Journal of Clinical and Experimental Cardiology. 5, 8, e136.

Research output: Contribution to journalEditorial

1 Scopus citations

Viral anti-inflammatory proteins target diverging immune pathways with converging effects on arterial dilatation, plaque and apoptosis

Davids, J. A., Dai, E., Chen, H., Bartee, M. Y., Liu, L., Fortunel, A., Moyer, R., Mcfadden, G. & Lucas, A. R., Jan 1 2014, In : European Journal of Inflammation. 12, 1, p. 131-145 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Viruses for tumor therapy

Bell, J. & McFadden, G., Mar 12 2014, In : Cell Host and Microbe. 15, 3, p. 260-265 6 p.

Research output: Contribution to journalReview article

74 Scopus citations

Women in cardiology: The x factor and the heart of medicine

Lucas, A., Eaverly, M., McFadden, G. & Bryant, M., Feb 2014, In : Journal of Clinical and Experimental Cardiology. 5, 2

Research output: Contribution to journalEditorial

2013

Cytokine synergy: An underappreciated contributor to innate anti-viral immunity

Bartee, E. & McFadden, G., Sep 1 2013, In : Cytokine. 63, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Evolution and divergence of the mammalian SAMD9/SAMD9L gene family

Lemos De Matos, A., Liu, J., McFadden, G. & Esteves, P. J., Jun 17 2013, In : BMC Evolutionary Biology. 13, 1, 121.

Research output: Contribution to journalArticle

22 Scopus citations

Myxoma and vaccinia viruses bind differentially to human leukocytes

Chan, W. M., Bartee, E. C., Moreb, J. S., Dower, K., Connor, J. H. & McFadden, G., Apr 2013, In : Journal of virology. 87, 8, p. 4445-4460 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Myxomaviral anti-inflammatory serpin reduces myeloid-derived suppressor cells and human pancreatic cancer cell growth in mice

Zheng, D., Chen, H., Bartee, M. Y., Williams, J., Davids, J. A., Lomas, D. A., McFadden, G. & Lucas, A. R., Sep 30 2013, In : Journal of Cancer Science and Therapy. 5, 8, p. 291-299 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection

Chen, H., Zheng, D., Abbott, J., Liu, L., Bartee, M. Y., Long, M., Davids, J., Williams, J., Feldmann, H., Strong, J., Grau, K. R., Tibbetts, S., Macaulay, C., McFadden, G., Thoburn, R., Lomas, D. A., Spinale, F. G., Virgin, H. W. & Lucas, A., Sep 2013, In : Antimicrobial Agents and Chemotherapy. 57, 9, p. 4114-4127 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Myxoma Virus Infection Promotes NK Lysis of Malignant Gliomas In Vitro and In Vivo

Ogbomo, H., Zemp, F. J., Lun, X., Zhang, J., Stack, D., Rahman, M. M., Mcfadden, G., Mody, C. H. & Forsyth, P. A., Jun 10 2013, In : PloS one. 8, 6, e66825.

Research output: Contribution to journalArticle

25 Scopus citations
31 Scopus citations

Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps

Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G. & Kubes, P., Feb 13 2013, In : Cell Host and Microbe. 13, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

189 Scopus citations

Oncolytic myxoma virus: The path to clinic

Chan, W. M., Rahman, M. M. & McFadden, G., Sep 6 2013, In : Vaccine. 31, 39, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Positive evolutionary selection on the RIG-I-like receptor genes in mammals

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Nov 27 2013, In : PloS one. 8, 11, e81864.

Research output: Contribution to journalArticle

20 Scopus citations

Resistance to Oncolytic Myxoma Virus Therapy in Nf1-/-/Trp53-/- Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

Zemp, F. J., McKenzie, B. A., Lun, X., Maxwell, L., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Jun 6 2013, In : PloS one. 8, 6, e65801.

Research output: Contribution to journalArticle

10 Scopus citations

The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation

Chen, H., Davids, J. A., Zheng, D., Bryant, M., Bot, I., van Berckel, T. J. C., Biessen, E., Pepine, C., Ryman, K., Progulski-Fox, A., Kesavalu, L., Moyer, R., McFadden, G. & Lucas, A., Jan 1 2013, In : Cardiovascular and Hematological Disorders - Drug Targets. 13, 2, p. 99-110 12 p.

Research output: Contribution to journalReview article

10 Scopus citations

The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells

Jeng, D., Ma, Z., Barrett, J. W., McFadden, G., Loeb, J. A. & Essania, K., Mar 1 2013, In : Journal of virology. 87, 6, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

6 Scopus citations