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  • Douglas McFadden
2013

Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps

Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G. & Kubes, P., Feb 13 2013, In : Cell Host and Microbe. 13, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

189 Scopus citations

Oncolytic myxoma virus: The path to clinic

Chan, W. M., Rahman, M. M. & McFadden, G., Sep 6 2013, In : Vaccine. 31, 39, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Positive evolutionary selection on the RIG-I-like receptor genes in mammals

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Nov 27 2013, In : PloS one. 8, 11, e81864.

Research output: Contribution to journalArticle

20 Scopus citations

Resistance to Oncolytic Myxoma Virus Therapy in Nf1-/-/Trp53-/- Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

Zemp, F. J., McKenzie, B. A., Lun, X., Maxwell, L., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Jun 6 2013, In : PloS one. 8, 6, e65801.

Research output: Contribution to journalArticle

10 Scopus citations

The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation

Chen, H., Davids, J. A., Zheng, D., Bryant, M., Bot, I., van Berckel, T. J. C., Biessen, E., Pepine, C., Ryman, K., Progulski-Fox, A., Kesavalu, L., Moyer, R., McFadden, G. & Lucas, A., Jan 1 2013, In : Cardiovascular and Hematological Disorders - Drug Targets. 13, 2, p. 99-110 12 p.

Research output: Contribution to journalReview article

10 Scopus citations

The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells

Jeng, D., Ma, Z., Barrett, J. W., McFadden, G., Loeb, J. A. & Essania, K., Mar 1 2013, In : Journal of virology. 87, 6, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin

Zemp, F. J., Lun, X., McKenzie, B. A., Zhou, H., Maxwell, L., Sun, B., Kelly, J. J. P., Stechishin, O., Luchman, A., Weiss, S., Cairncross, J. G., Hamilton, M. G., Rabinovich, B. A., Rahman, M. M., Mohamed, M. R., Smallwood, S., Senger, D. L., Bell, J., McFadden, G. & Forsyth, P. A., Jul 2013, In : Neuro-Oncology. 15, 7, p. 904-920 17 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro

Madlambayan, G. J., Bartee, E., Kim, M., Rahman, M. M., Meacham, A., Scott, E. W., McFadden, G. & Cogle, C. R., May 1 2012, In : Leukemia Research. 36, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Bugs and drugs: Oncolytic virotherapy in combination with chemotherapy

Wennier, S. T., Liu, J. & McFadden, G., Jul 1 2012, In : Current Pharmaceutical Biotechnology. 13, 9, p. 1817-1833 17 p.

Research output: Contribution to journalArticle

34 Scopus citations

Innate immune response of human Plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain

Cao, H., Dai, P., Wang, W., Li, H., Yuan, J., Wang, F., Fang, C. M., Pitha, P. M., Liu, J., Condit, R. C., McFadden, G., Merghoub, T., Houghton, A. N., Young, J. W., Shuman, S. & Deng, L., May 14 2012, In : PloS one. 7, 5, e36823.

Research output: Contribution to journalArticle

16 Scopus citations

Myxoma virus M064 Is a novel member of the poxvirus C7l superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits

Liu, J., Wennier, S., Moussatche, N., Reinhard, M., Condit, R. & McFadden, G., May 2012, In : Journal of virology. 86, 9, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity

Correa, R. J. M., Komar, M., Tong, J. G. K., Sivapragasam, M., Rahman, M. M., McFadden, G., Dimattia, G. E. & Shepherd, T. G., May 2012, In : Gynecologic Oncology. 125, 2, p. 441-450 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer

Wennier, S. T., Liu, J., Li, S., Rahman, M. M., Mona, M. & McFadden, G., Apr 2012, In : Molecular Therapy. 20, 4, p. 759-768 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Oncolytic virotherapy for hematological malignancies

Bais, S., Bartee, E., Rahman, M. M., McFadden, G. & Cogle, C. R., Dec 1 2012, In : Advances in Virology. 2012, 186512.

Research output: Contribution to journalReview article

22 Scopus citations

Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplantation Grafts using Oncolytic Myxoma Virus

Bartee, E., Chan, W. M., Moreb, J. S., Cogle, C. R. & McFadden, G., Oct 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 10, p. 1540-1551 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

The poxvirus C7L host range factor superfamily

Liu, J., Rothenburg, S. & McFadden, G., Dec 2012, In : Current opinion in virology. 2, 6, p. 764-772 9 p.

Research output: Contribution to journalReview article

11 Scopus citations

Virotherapy using Myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells

Bartee, E., Meacham, A., Wise, E., Cogle, C. R. & McFadden, G., Aug 14 2012, In : PloS one. 7, 8, e43298.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Building bridges between plant and animal viruses

McFadden, G. & Simon, A. E., Nov 2011, In : Current opinion in virology. 1, 5, p. 319-321 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells

France, M. R., Thomas, D. L., Liu, J., McFadden, G., MacNeill, A. L. & Roy, E. J., Jan 1 2011, In : Journal of General Virology. 92, 1, p. 195-199 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells

Liu, J., Wennier, S., Zhang, L. & McFadden, G., Apr 1 2011, In : Journal of virology. 85, 7, p. 3270-3282 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Modulation of NF-κB signalling by microbial pathogens

Rahman, M. M. & McFadden, G., Apr 1 2011, In : Nature Reviews Microbiology. 9, 4, p. 291-306 16 p.

Research output: Contribution to journalReview article

176 Scopus citations

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

Thomas, D. L., Doty, R., Tosic, V., Liu, J., Kranz, D. M., McFadden, G., MacNeill, A. L. & Roy, E. J., Oct 1 2011, In : Cancer Immunology, Immunotherapy. 60, 10, p. 1461-1472 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Myxoma virus induces type i interferon production in murine plasmacytoid dendritic cells via a TLR9/myd88-,IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Oct 2011, In : Journal of virology. 85, 20, p. 10814-10825 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/Myd88-, IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Dec 2011, In : Journal of virology. 85, 23, p. 12835 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
35 Scopus citations

Oncolytic virotherapy for pancreatic cancer.

Wennier, S., Li, S. & McFadden, G., Oct 7 2011, In : Expert reviews in molecular medicine. 13, p. e18

Research output: Contribution to journalReview article

23 Scopus citations

Production of myxoma virus gateway entry and expression libraries and validation of viral protein expression

Smallwood, S. E., Rahman, M. M., Werden, S. J., Martino, M. F. & McFadden, G., Aug 29 2011, In : Current Protocols in Microbiology. SUPPL.21

Research output: Contribution to journalArticle

2 Scopus citations

The current status and future directions of myxoma virus, a master in immune evasion

Spiesschaert, B., McFadden, G., Hermans, K., Nauwynck, H. & Van De Walle, G. R., 2011, In : Veterinary Research. 42, 1, 76.

Research output: Contribution to journalReview article

28 Scopus citations

Tumor necrosis factor inhibitors from poxviruses with an emphasis on tanapoxvirus-2L protein

Jeng, D., Rahman, M. M., McFadden, G. & Essani, K., Aug 1 2011, In : Recent Patents on DNA and Gene Sequences. 5, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Viral serpin therapeutics: From concept to clinic

Chen, H., Zheng, D., Davids, J., Bartee, M. Y., Dai, E., Liu, L., Petrov, L., Macaulay, C., Thoburn, R., Sobel, E., Moyer, R., McFadden, D. & Lucas, A., Jun 24 2011, In : Methods in Enzymology. 499, p. 301-329 29 p.

Research output: Contribution to journalArticle

16 Scopus citations