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  • Douglas McFadden
Article

Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro

Madlambayan, G. J., Bartee, E., Kim, M., Rahman, M. M., Meacham, A., Scott, E. W., McFadden, G. & Cogle, C. R., May 1 2012, In : Leukemia Research. 36, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Are We There Yet? The Smallpox Research Agenda Using Variola Virus

Damon, I. K., Damaso, C. R. & McFadden, G., May 2014, In : PLoS Pathogens. 10, 5, e1004108.

Research output: Contribution to journalArticle

14 Scopus citations

Autologous Transplantation Using Donor Leukocytes Loaded Ex Vivo with Oncolytic Myxoma Virus Can Eliminate Residual Multiple Myeloma

Villa, N. Y., Rahman, M. M., Mamola, J., D'Isabella, J., Goras, E., Kilbourne, J., Lowe, K., Daggett-Vondras, J., Torres, L., Christie, J., Appel, N., Cox, A. L., Kim, J. B. & McFadden, G., Sep 25 2020, In : Molecular Therapy - Oncolytics. 18, p. 171-188 18 p.

Research output: Contribution to journalArticle

Open Access

Bugs and drugs: Oncolytic virotherapy in combination with chemotherapy

Wennier, S. T., Liu, J. & McFadden, G., Jul 1 2012, In : Current Pharmaceutical Biotechnology. 13, 9, p. 1817-1833 17 p.

Research output: Contribution to journalArticle

34 Scopus citations

Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus

Zemp, F. J., McKenzie, B. A., Lun, X., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Dec 15 2014, In : Cancer Research. 74, 24, p. 7260-7273 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Coinfections of novel polyomavirus, anelloviruses and a recombinant strain of myxoma virus-MYXV-tol identified in Iberian hares

Ägueda-Pinto, A., Kraberger, S., Lund, M. C., Gortázar, C., McFadden, G., Varsani, A. & Esteves, P. J., Jan 1 2020, In : Viruses. 12, 3, 340.

Research output: Contribution to journalArticle

Open Access

Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function

Mahon, B. P., Ambadapadi, S., Yaron, J. R., Lomelino, C. L., Pinard, M. A., Keinan, S., Kurnikov, I., Macaulay, C., Zhang, L., Reeves, W., McFadden, D., Tibbetts, S., McKenna, R. & Lucas, A. R., Feb 20 2018, In : Biochemistry. 57, 7, p. 1096-1107 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cytokine synergy: An underappreciated contributor to innate anti-viral immunity

Bartee, E. & McFadden, G., Sep 1 2013, In : Cytokine. 63, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Evolution and divergence of the mammalian SAMD9/SAMD9L gene family

Lemos De Matos, A., Liu, J., McFadden, G. & Esteves, P. J., Jun 17 2013, In : BMC Evolutionary Biology. 13, 1, 121.

Research output: Contribution to journalArticle

22 Scopus citations

Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Jan 1 2014, In : Immunogenetics. 66, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ex vivo virotherapy with myxoma virus does not impair hematopoietic stem and progenitor cells

Villa, N., Bais, S., Chan, W. M., Meacham, A. M., Wise, E., Rahman, M., Moreb, J. S., Rosenau, E. H., Wingard, J. R., McFadden, D. & Cogle, C. R., Mar 1 2016, In : Cytotherapy. 18, 3, p. 465-480 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetic characterization of a recombinant myxoma virus in the iberian hare (Lepus granatensis)

Águeda-Pinto, A., Matos, A. L. D., Abrantes, M., Kraberger, S., Risalde, M. A., Gortázar, C., McFadden, G., Varsani, A. & Esteves, P. J., Jun 2019, In : Viruses. 11, 6, 530.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Genome characterization of cetaceanpox virus from a managed Indo-Pacific bottlenose dolphin (Tursiops aduncus)

Rodrigues, T. C. S., Subramaniam, K., Varsani, A., McFadden, G., Schaefer, A. M., Bossart, G. D., Romero, C. H. & Waltzek, T. B., Mar 2020, In : Virus research. 278, 197861.

Research output: Contribution to journalArticle

Innate immune response of human Plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain

Cao, H., Dai, P., Wang, W., Li, H., Yuan, J., Wang, F., Fang, C. M., Pitha, P. M., Liu, J., Condit, R. C., McFadden, G., Merghoub, T., Houghton, A. N., Young, J. W., Shuman, S. & Deng, L., May 14 2012, In : PloS one. 7, 5, e36823.

Research output: Contribution to journalArticle

16 Scopus citations

Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells

France, M. R., Thomas, D. L., Liu, J., McFadden, G., MacNeill, A. L. & Roy, E. J., Jan 1 2011, In : Journal of General Virology. 92, 1, p. 195-199 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

Pisklakova, A., McKenzie, B., Zemp, F., Lun, X., Kenchappa, R. S., Etame, A. B., Rahman, M. M., Reilly, K., Pilon-Thomas, S., McFadden, G., Kurz, E. & Forsyth, P. A., Aug 1 2016, In : Neuro-Oncology. 18, 8, p. 1088-1098 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells

Liu, J., Wennier, S., Zhang, L. & McFadden, G., Apr 1 2011, In : Journal of virology. 85, 7, p. 3270-3282 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Myxoma and vaccinia viruses bind differentially to human leukocytes

Chan, W. M., Bartee, E. C., Moreb, J. S., Dower, K., Connor, J. H. & McFadden, G., Apr 2013, In : Journal of virology. 87, 8, p. 4445-4460 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Myxomaviral anti-inflammatory serpin reduces myeloid-derived suppressor cells and human pancreatic cancer cell growth in mice

Zheng, D., Chen, H., Bartee, M. Y., Williams, J., Davids, J. A., Lomas, D. A., McFadden, G. & Lucas, A. R., Sep 30 2013, In : Journal of Cancer Science and Therapy. 5, 8, p. 291-299 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

Thomas, D. L., Doty, R., Tosic, V., Liu, J., Kranz, D. M., McFadden, G., MacNeill, A. L. & Roy, E. J., Oct 1 2011, In : Cancer Immunology, Immunotherapy. 60, 10, p. 1461-1472 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection

Chen, H., Zheng, D., Abbott, J., Liu, L., Bartee, M. Y., Long, M., Davids, J., Williams, J., Feldmann, H., Strong, J., Grau, K. R., Tibbetts, S., Macaulay, C., McFadden, G., Thoburn, R., Lomas, D. A., Spinale, F. G., Virgin, H. W. & Lucas, A., Sep 2013, In : Antimicrobial Agents and Chemotherapy. 57, 9, p. 4114-4127 14 p.

Research output: Contribution to journalArticle

19 Scopus citations
Open Access

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PloS one. 9, 10, e109801.

Research output: Contribution to journalArticle

20 Scopus citations

Myxoma virus induces type i interferon production in murine plasmacytoid dendritic cells via a TLR9/myd88-,IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Oct 2011, In : Journal of virology. 85, 20, p. 10814-10825 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Myxoma Virus Infection Promotes NK Lysis of Malignant Gliomas In Vitro and In Vivo

Ogbomo, H., Zemp, F. J., Lun, X., Zhang, J., Stack, D., Rahman, M. M., Mcfadden, G., Mody, C. H. & Forsyth, P. A., Jun 10 2013, In : PloS one. 8, 6, e66825.

Research output: Contribution to journalArticle

25 Scopus citations
35 Scopus citations

Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs

Garg, R. R., Jackson, C. B., Rahman, M. M., Khan, A. R., Lewin, A. S. & McFadden, G., May 24 2019, In : Journal of Biological Chemistry. 294, 21, p. 8480-8489 10 p.

Research output: Contribution to journalArticle

Myxoma virus M064 Is a novel member of the poxvirus C7l superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits

Liu, J., Wennier, S., Moussatche, N., Reinhard, M., Condit, R. & McFadden, G., May 2012, In : Journal of virology. 86, 9, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
23 Scopus citations

Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity

Correa, R. J. M., Komar, M., Tong, J. G. K., Sivapragasam, M., Rahman, M. M., McFadden, G., Dimattia, G. E. & Shepherd, T. G., May 2012, In : Gynecologic Oncology. 125, 2, p. 441-450 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
31 Scopus citations

Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer

Wennier, S. T., Liu, J., Li, S., Rahman, M. M., Mona, M. & McFadden, G., Apr 2012, In : Molecular Therapy. 20, 4, p. 759-768 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps

Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G. & Kubes, P., Feb 13 2013, In : Cell Host and Microbe. 13, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

189 Scopus citations

Oncolytic myxoma virus: The path to clinic

Chan, W. M., Rahman, M. M. & McFadden, G., Sep 6 2013, In : Vaccine. 31, 39, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Oncolytic poxviruses

Chan, W. M. & McFadden, D., Sep 29 2014, In : Annual Review of Virology. 1, 1, p. 191-214 24 p.

Research output: Contribution to journalArticle

51 Scopus citations

Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival

Kellish, P., Shabashvili, D., Rahman, M. M., Nawab, A., Guijarro, M. V., Zhang, M., Cao, C., Moussatche, N., Boyle, T., Antonia, S., Reinhard, M., Hartzell, C., Jantz, M., Mehta, H. J., McFadden, G., Kaye, F. J. & Zajac-Kaye, M., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2279-2292 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Oncolytic Virus-Mediated RAS Targeting in Rhabdomyosarcoma

Phelps, M. P., Yang, H., Patel, S., Rahman, M., McFadden, D. & Chen, E., Dec 21 2018, In : Molecular Therapy - Oncolytics. 11, p. 52-61 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Parallel adaptation of rabbit populations to myxoma virus

Alves, J. M., Carneiro, M., Cheng, J. Y., de Matos, A. L., Rahman, M., Loog, L., Campos, P. F., Wales, N., Eriksson, A., Manica, A., Strive, T., Graham, S. C., Afonso, S., Bell, D. J., Belmont, L., Day, J. P., Fuller, S. J., Marchandeau, S., Palmer, W. J., Queney, G. & 9 others, Surridge, A. K., Vieira, F. G., McFadden, D., Nielsen, R., Thomas, M., Gilbert, P., Esteves, P. J., Ferrand, N. & Jiggins, F. M., Mar 22 2019, In : Science. 363, 6433, p. 1319-1326 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Positive evolutionary selection on the RIG-I-like receptor genes in mammals

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Nov 27 2013, In : PloS one. 8, 11, e81864.

Research output: Contribution to journalArticle

20 Scopus citations

Production of myxoma virus gateway entry and expression libraries and validation of viral protein expression

Smallwood, S. E., Rahman, M. M., Werden, S. J., Martino, M. F. & McFadden, G., Aug 29 2011, In : Current Protocols in Microbiology. SUPPL.21

Research output: Contribution to journalArticle

2 Scopus citations

Quantifying Antibody Responses Induced by Antigen-Agnostic Immunotherapies

van Vloten, J. P., Klafuric, E. M., Karimi, K., McFadden, G., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Sep 13 2019, In : Molecular Therapy - Methods and Clinical Development. 14, p. 189-196 8 p.

Research output: Contribution to journalArticle

Open Access

Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies

van Vloten, J. P., Santry, L. A., McAusland, T. M., Karimi, K., McFadden, D., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Jun 14 2019, In : Molecular Therapy - Methods and Clinical Development. 13, p. 154-166 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
6 Scopus citations

Resistance to Oncolytic Myxoma Virus Therapy in Nf1-/-/Trp53-/- Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

Zemp, F. J., McKenzie, B. A., Lun, X., Maxwell, L., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Jun 6 2013, In : PloS one. 8, 6, e65801.

Research output: Contribution to journalArticle

10 Scopus citations

Scalable collaborative infrastructure for a learning healthcare system (SCILHS): Architecture

Mandl, K. D., Kohane, I. S., McFadden, D., Weber, G. M., Natter, M., Mandel, J., Schneeweiss, S., Weiler, S., Klann, J. G., Bickel, J., Adams, W. G., Ge, Y., Zhou, X., Perkins, J., Marsolo, K., Berns tam, E., Showalter, J., Quarshie, A., Ofili, E., Hripcsak, G. & 1 others, Murphy, S. N., Jan 1 2014, In : Journal of the American Medical Informatics Association. 21, 4, p. 615-620 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplantation Grafts using Oncolytic Myxoma Virus

Bartee, E., Chan, W. M., Moreb, J. S., Cogle, C. R. & McFadden, G., Oct 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 10, p. 1540-1551 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus

Brahn, E., Lee, S., Lucas, A., McFadden, G. & MaCaulay, C., Aug 2014, In : Clinical Immunology. 153, 2, p. 254-263 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma

Tang, B., Guo, Z. S., Bartlett, D. L., Yan, D. Z., Schane, C. P., Thomas, D. L., Liu, J., McFadden, G., Shisler, J. L., Roy, E. J. & Roy, E. J., May 1 2020, In : Clinical Cancer Research. 26, 9, p. 2216-2230 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Targeting gallbladder cancer: Oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo

Weng, M., Gong, W., Ma, M., Chu, B., Qin, Y., Zhang, M., Lun, X., McFadden, G., Forsyth, P., Yang, Y. & Quan, Z., Apr 13 2014, In : Molecular Cancer. 13, 1, 82.

Research output: Contribution to journalArticle

12 Scopus citations

The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells

Jeng, D., Ma, Z., Barrett, J. W., McFadden, G., Loeb, J. A. & Essania, K., Mar 1 2013, In : Journal of virology. 87, 6, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

6 Scopus citations