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• Review article

  Femtosecond nanocrystallography using X-ray lasers for membrane protein structure determination

  Fromme, P. & Spence, J., Aug 2011, In: Current Opinion in Structural Biology. 21, 4, p. 509-516 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • X Ray Crystallography
  • Membrane Proteins
  • Lasers
  • X-Rays
  • Crystallography
  59 Scopus citations

• Injector for scattering measurements on fully solvated biospecies

  Weierstall, U., Spence, J. & Doak, R. B., Mar 1 2012, In: Review of Scientific Instruments. 83, 3, 035108.

  Research output: Contribution to journal › Review article › peer-review

  • injectors
  • Scattering
  • Gases
  • Gas dynamics
  • Vacuum
  160 Scopus citations
• Letter

  Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser

  Kupitz, C., Basu, S., Grotjohann, I., Fromme, R., Zatsepin, N., Rendek, K. N., Hunter, M. S., Shoeman, R. L., White, T. A., Wang, D., James, D., Yang, J. H., Cobb, D. E., Reeder, B., Sierra, R. G., Liu, H., Barty, A., Aquila, A. L., Deponte, D., Kirian, R. & 39 others, Bari, S., Bergkamp, J. J., Beyerlein, K. R., Bogan, M. J., Caleman, C., Chao, T. C., Conrad, C. E., Davis, K. M., Fleckenstein, H., Galli, L., Hau-Riege, S. P., Kassemeyer, S., Laksmono, H., Liang, M., Lomb, L., Marchesini, S., Martin, A. V., Messerschmidt, M., Milathianaki, D., Nass, K., Ros, A., Roy-Chowdhury, S., Schmidt, K., Seibert, M., Steinbrener, J., Stellato, F., Yan, L., Yoon, C., Moore, T., Moore, A., Pushkar, Y., Williams, G. J., Boutet, S., Doak, R. B., Weierstall, U., Frank, M., Chapman, H. N., Spence, J. & Fromme, P., 2014, In: Nature. 513, 7517, p. 261-265 5 p.

  Research output: Contribution to journal › Letter › peer-review

  • Photosystem II Protein Complex
  • Crystallography
  • Photosynthesis
  • Lasers
  • X-Rays
  301 Scopus citations
• Editorial

  Preface

  Hawkes, P. W. & Spence, J. C. H., Jan 1 2019, In: Springer Handbooks. p. V-IX

  Research output: Contribution to journal › Editorial › peer-review

• The birth of a new field

  Spence, J. & Chapman, H. N., Jul 17 2014, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130309.

  Research output: Contribution to journal › Editorial › peer-review
  24 Scopus citations

• X-ray lasers and crystallography

  Spence, J., Apr 30 2014, In: IUCrJ. 1, p. 151-152 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Scopus citations

• X-ray lasers and serial crystallography

  Spence, J., Apr 30 2015, In: IUCrJ. 2, p. 305-306 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  5 Scopus citations
• Conference contribution

  Biphasic droplet-based sample delivery of protein crystals for serial femtosecond crystallography with an x-ray free electron laser

  Echelmeier, A., Nelson, G., Abdallah, B. G., James, D., Roy-Chowdhury, S., Tolstikova, A., Mariani, V., Kirian, R., Oberthüer, D., Dörner, K., Fromme, P., Chapman, H. N., Weierstall, U., Spence, J. & Ros, A., 2015, MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 1374-1376 3 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Crystallography
  • Crystals
  • Proteins
  • X ray lasers
  • X rays
  4 Scopus citations

• Image reconstruction in serial femtosecond nanocrystallography using x-ray free-electron lasers

  Chen, J. P. J., Kirian, R., Beyerlein, K. R., Bean, R. J., Morgan, A. J., Yefanov, O. M., Arnal, R. D., Wojtas, D. H., Bones, P. J., Chapman, H. N., Spence, J. & Millane, R. P., 2015, Proceedings of SPIE - The International Society for Optical Engineering. SPIE, Vol. 9600. 960002

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • X-ray Laser
  • Femtosecond
  • Free Electron Laser
  • Free electron lasers
  • Image Reconstruction
  1 Scopus citations

• Microscopic linear liquid streams in vacuum: Injection of solvated biological samples into X-ray free electron lasers

  Doak, R. B., Deponte, D. P., Nelson, G., Camacho-Alanis, F., Ros, A., Spence, J. & Weierstall, U., Dec 1 2012, 28th International Symposium on Rarefied Gas Dynamics 2012. 1 ed. p. 1314-1323 10 p. (AIP Conference Proceedings; vol. 1501, no. 1).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • gas dynamics
  • free electron lasers
  • free flow
  • injection
  • vacuum
  8 Scopus citations

• Phase retrieval in femtosecond X-ray nanocrystallography

  Chen, J. P. J., Spence, J. & Millane, R. P., Dec 1 2012, Proceedings of IVCNZ 2012 - The 27th Image and Vision Computing New Zealand Conference. p. 43-48 6 p. (ACM International Conference Proceeding Series).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Diffraction
  • Crystals
  • Charge density
  • X rays
  • X ray crystallography
  2 Scopus citations

• Phase retrieval in nanocrystallography

  Chen, J. P. J., Spence, J. & Millane, R. P., Dec 1 2012, Image Reconstruction from Incomplete Data VII. 85000I. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 8500).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Phase Retrieval
  • Diffraction
  • retrieval
  • Crystal
  • Crystals

• Sample consumption reduction for serial crystallography using water-in-oil droplets

  Echelmeier, A., Villarreal, J. C., Kim, D., Gandhi, S., Egatz-Gomez, A., Thifault, D., Coe, J. D., Brehm, G., Madsen, C., Quintana, S., Bajt, S., Messerschmidt, M., Meza-Aguilar, J. D., Oberthür, D., Wiedorn, M. O., Fleckenstein, H., Botha, S., Mendez, D., Knoska, J., Garcia, J. M. & 37 others, Hu, H., Lisova, S., Gholi, A. A., Gevorkov, Y., Ayyer, K., Aplin, S. J., Ginn, H. M., Graafsma, H., Morgan, A. J., Greiffenberg, D., Klujev, A., Laurus, T., Poehlsen, J., Trunk, U., Maia, F. R. N. C., Mezza, D., Fromme, R., Weinhausen, B., Mills, G., Vagovic, P., Kim, Y., Schulz, J., Dörner, K., Sztuk-Dambietz, J., Kuhn, M., Grant, T. D., White, T. A., Mariani, V., Barty, A., Mancuso, A. P., Weierstall, U., Spence, J. C. H., Chapman, H. N., Zatsepin, N. A., Fromme, P., Kirian, R. A. & Ros, A., 2019, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. Chemical and Biological Microsystems Society, p. 1476-1477 2 p. (23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Crystallography
  • X ray lasers
  • Free electron lasers
  • Oils
  • 2-dehydro-3-deoxyphosphooctonate aldolase
• Conference article

  Development of coherent scattering and diffractive imaging and the COSMIC facility at the Advanced Light Source

  Shapiro, D., Roy, S., Celestre, R., Chao, W., Doering, D., Howells, M., Kevan, S., Kilcoyne, D., Kirz, J., Marchesini, S., Seu, K. A., Schirotzek, A., Spence, J., Tyliszczak, T., Warwick, T., Voronov, D. & Padmore, H. A., 2013, In: Journal of Physics: Conference Series. 425, PART 19, 192011.

  Research output: Contribution to journal › Conference article › peer-review

  • coherent scattering
  • light sources
  • data transmission
  • cryogenic temperature
  • charge coupled devices
  7 Scopus citations

• Near edge fine structure analysis of copper in Cu-Bi₂Se₃ topological insulators

  Subramanian, G., Jiang, N., Chen, Y. & Spence, J., Aug 1 2014, In: Microscopy and Microanalysis. 20, 3, p. 160-161 2 p.

  Research output: Contribution to journal › Conference article › peer-review
  1 Scopus citations

• Solving protein nanocrystals by cryo-EM: Multiple scattering artifacts

  Subramanian, G., Basu, S., Liu, H., Zuo, J. M. & Spence, J., Aug 1 2014, In: Microscopy and Microanalysis. 20, 3, p. 1242-1243 2 p.

  Research output: Contribution to journal › Conference article › peer-review
• Comment/debate

  Erratum: Signal, noise, and resolution in correlated fluctuations from snapshot small-angle x-ray scattering (Physical Review E (2011) 84 (011921) DOI:10.1103/PhysRevE.84.011921)

  Kirian, R., Schmidt, K., Wang, X., Doak, R. B. & Spence, J., Nov 22 2011, In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 84, 5, 059907.

  Research output: Contribution to journal › Comment/debate › peer-review

• Instrumentation and methods: General discussion

  Küpper, J., Williams, G., Chapman, H., Reid, K., Christensen, J., Wörner, H. J., Seddon, E., Dixit, G., Campbell, E., Underwood, J., Woerner, M., Spence, J., Van Thor, J., Wolf, M., Vendrell, O., De Ninno, G., Bressler, C. & Berrah, N., Dec 1 2014, In: Faraday Discussions. 171, p. 505-523 19 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Scopus citations
• Chapter

  Diffractive imaging of single particles

  Spence, J. C. H., Jan 1 2019, Springer Handbooks. Springer, p. 1009-1036 28 p. (Springer Handbooks).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • x ray lasers
  • uniqueness
  • x rays
  • far fields
  • electron microscopy
• Article

  7 Å resolution in protein twodimensional-crystal X-ray diffraction at Linac Coherent Light Source

  Pedrini, B., Tsai, C. J., Capitani, G., Padeste, C., Hunter, M. S., Zatsepin, N., Barty, A., Henry Benner, W., Boutet, S., Feld, G. K., Hau-Riege, S. P., Kirian, R., Kupitz, C., Messerschmitt, M., Ogren, J. I., Pardini, T., Segelke, B., Williams, G. J., Spence, J., Abela, R. & 5 others, Coleman, M., Evans, J. E., Schertler, G. F. X., Frank, M. & Li, X. D., Jul 17 2014, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130500.

  Research output: Contribution to journal › Article › peer-review

  • X ray lasers
  • crystal proteins
  • X-Ray Diffraction
  • Free electron lasers
  • Light sources
  30 Scopus citations

• Ab-initio phasing using nanocrystal shape transforms with incomplete unit cells

  Liu, H., Zatsepin, N. & Spence, J., Jan 1 2014, In: IUCrJ. 1, p. 19-27 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Nanocrystals
  • Crystals
  • Nanoparticles
  • nanocrystals
  • cells
  14 Scopus citations

• A novel inert crystal delivery medium for serial femtosecond crystallography

  Conrad, C. E., Basu, S., James, D., Wang, D., Schaffer, A., Roy-Chowdhury, S., Zatsepin, N., Aquila, A., Coe, J., Gati, C., Hunter, M. S., Koglin, J. E., Kupitz, C., Nelson, G., Subramanian, G., White, T. A., Zhao, Y., Zook, J., Boutet, S., Cherezov, V. & 4 others, Spence, J., Fromme, R., Weierstall, U. & Fromme, P., Jul 1 2015, In: IUCrJ. 2, p. 421-430 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Crystallography
  • crystallography
  • Crystals
  • delivery
  • Proteins
  84 Scopus citations

• Approaches to time-resolved diffraction using an XFEL

  Spence, J., Dec 1 2014, In: Faraday Discussions. 171, p. 429-438 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Diffraction
  • delivery
  • diffraction
  • recording
  • Crystallography
  17 Scopus citations

• Automatic recovery of missing amplitudes and phases in tilt-limited electron crystallography of two-dimensional crystals

  Gipson, B. R., Masiel, D. J., Browning, N. D., Spence, J., Mitsuoka, K. & Stahlberg, H., Jul 22 2011, In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 84, 1, 011916.

  Research output: Contribution to journal › Article › peer-review

  • Tilt
  • crystallography
  • Crystal
  • Electron
  • Recovery
  18 Scopus citations

• Casimir torque between birefringent plates with metamaterials

  Chen, X. & Spence, J., Sep 2013, In: Physica Status Solidi (A) Applications and Materials Science. 210, 9, p. 1925-1932 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Refractive index
  • Metamaterials
  • torque
  • Torque
  • refractivity
  4 Scopus citations

• Coherent convergent-beam time-resolved X-ray diffraction

  Spence, J., Zatsepin, N. & Li, C., Jul 17 2014, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130325.

  Research output: Contribution to journal › Article › peer-review

  • X ray lasers
  • Nanocrystals
  • X-Ray Diffraction
  • X-ray diffraction
  • X ray diffraction
  11 Scopus citations

• Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

  Kang, Y., Zhou, X. E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T. A., Yefanov, O., Han, G. W., Xu, Q., De Waal, P. W., Ke, J., Tan, M. H. E., Zhang, C., Moeller, A., West, G. M., Pascal, B. D., Van Eps, N., Caro, L. N. & 52 others, Vishnivetskiy, S. A., Lee, R. J., Suino-Powell, K. M., Gu, X., Pal, K., Ma, J., Zhi, X., Boutet, S., Williams, G. J., Messerschmidt, M., Gati, C., Zatsepin, N., Wang, D., James, D., Basu, S., Roy-Chowdhury, S., Conrad, C. E., Coe, J., Liu, H., Lisova, S., Kupitz, C., Grotjohann, I., Fromme, R., Jiang, Y., Tan, M., Yang, H., Li, J., Wang, M., Zheng, Z., Li, D., Howe, N., Zhao, Y., Standfuss, J., Diederichs, K., Dong, Y., Potter, C. S., Carragher, B., Caffrey, M., Jiang, H., Chapman, H. N., Spence, J., Fromme, P., Weierstall, U., Ernst, O. P., Katritch, V., Gurevich, V. V., Griffin, P. R., Hubbell, W. L., Stevens, R. C., Cherezov, V., Melcher, K. & Xu, H. E., Jul 30 2015, In: Nature. 523, 7562, p. 561-567 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Arrestin
  • Rhodopsin
  • Lasers
  • X-Rays
  • G-Protein-Coupled Receptors
  457 Scopus citations

• Data collection strategies for time-resolved X-ray free-electron laser diffraction, and 2-color methods

  Li, C., Schmidt, K. & Spence, J., Jul 1 2015, In: Structural Dynamics. 2, 4, 041714.

  Research output: Contribution to journal › Article › peer-review

  • X ray lasers
  • Free electron lasers
  • Diffraction
  • free electron lasers
  • Goniometers
  7 Scopus citations

• Direct phasing in femtosecond nanocrystallography. I. Diffraction characteristics

  Chen, J. P. J., Spence, J. & Millane, R. P., Mar 2014, In: Acta Crystallographica Section A: Foundations and Advances. 70, 2, p. 143-153 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Diffraction
  • Noise
  • Nanoparticles
  • X-Rays
  • Nanocrystals
  13 Scopus citations

• Direct phasing in femtosecond nanocrystallography. II. Phase retrieval

  Chen, J. P. J., Spence, J. & Millane, R. P., Mar 2014, In: Acta Crystallographica Section A: Foundations and Advances. 70, 2, p. 154-161 8 p.

  Research output: Contribution to journal › Article › peer-review

  • X ray lasers
  • Free electron lasers
  • Nanocrystals
  • Diffraction patterns
  • Carrier concentration
  10 Scopus citations

• Double-focusing mixing jet for XFEL study of chemical kinetics

  Wang, D., Weierstall, U., Pollack, L. & Spence, J., Nov 1 2014, In: Journal of synchrotron radiation. 21, 6, p. 1364-1366 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Reaction kinetics
  • reaction kinetics
  • Liquids
  • X ray lasers
  • liquids
  50 Scopus citations

• Electronic damage in S atoms in a native protein crystal induced by an intense X-ray free-electron laser pulse

  Galli, L., Son, S. K., Klinge, M., Bajt, S., Barty, A., Bean, R., Betzel, C., Beyerlein, K. R., Caleman, C., Doak, R. B., Duszenko, M., Fleckenstein, H., Gati, C., Hunt, B., Kirian, R., Liang, M., Nanao, M. H., Nass, K., Oberthür, D., Redecke, L. & 7 others, Shoeman, R., Stellato, F., Yoon, C. H., White, T. A., Yefanov, O., Spence, J. & Chapman, H. N., Jul 1 2015, In: Structural Dynamics. 2, 4, 041703.

  Research output: Contribution to journal › Article › peer-review

  • X ray lasers
  • Free electron lasers
  • Radiation damage
  • Laser pulses
  • Light sources
  11 Scopus citations

• Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

  Lee, H. H., Cherni, I., Yu, H., Fromme, R., Doran, J. D., Grotjohann, I., Mittman, M., Basu, S., Deb, A., Dörner, K., Aquila, A., Barty, A., Boutet, S., Chapman, H. N., Doak, R. B., Hunter, M. S., James, D., Kirian, R., Kupitz, C., Lawrence, R. M. & 17 others, Liu, H., Nass, K., Schlichting, I., Schmidt, K., Seibert, M. M., Shoeman, R. L., Spence, J., Stellato, F., Weierstall, U., Williams, G. J., Yoon, C., Wang, D., Zatsepin, N., Hogue, B., Matoba, N., Fromme, P. & Leket-Mor, T., Aug 29 2014, In: IUCrJ. 1, p. 305-317 13 p.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • human immunodeficiency virus
  • Vaccines
  • Crystallization
  • Viruses
  6 Scopus citations

• Femtosecond free-electron laser X-ray diffraction data sets for algorithm development

  Kassemeyer, S., Steinbrener, J., Lomb, L., Hartmann, E., Aquila, A., Barty, A., Martin, A. V., Hampton, C. Y., Bajt, S., Barthelmess, M., Barends, T. R. M., Bostedt, C., Bott, M., Bozek, J. D., Coppola, N., Cryle, M., De Ponte, D. P., Doak, R. B., Epp, S. W., Erk, B. & 42 others, Fleckenstein, H., Foucar, L., Graafsma, H., Gumprecht, L., Hartmann, A., Hartmann, R., Hauser, G., Hirsemann, H., Hömke, A., Holl, P., Jönsson, O., Kimmel, N., Krasniqi, F., Liang, M., Maia, F. R. N. C., Marchesini, S., Nass, K., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Schmidt, C., Schulz, J., Shoeman, R. L., Sierra, R. G., Soltau, H., Spence, J., Starodub, D., Stellato, F., Stern, S., Stier, G., Svenda, M., Weidenspointner, G., Weierstall, U., White, T. A., Wunderer, C., Frank, M., Chapman, H. N., Ullrich, J., Strüder, L., Bogan, M. J. & Schlichting, I., Feb 13 2012, In: Optics Express. 20, 4, p. 4149-4158 10 p.

  Research output: Contribution to journal › Article › peer-review

  • free electron lasers
  • diffraction
  • x rays
  • viruses
  • assembling
  57 Scopus citations

• Femtosecond X-ray diffraction from two-dimensional protein crystals

  Frank, M., Carlson, D. B., Hunter, M. S., Williams, G. J., Messerschmidt, M., Zatsepin, N., Barty, A., Benner, W. H., Chu, K., Graf, A. T., Hau-Riege, S. P., Kirian, R., Padeste, C., Pardini, T., Pedrini, B., Segelke, B., Seibert, M. M., Spence, J., Tsai, C. J., Lane, S. M. & 5 others, Li, X. D., Schertler, G., Boutet, S., Coleman, M. & Evans, J. E., Feb 28 2014, In: IUCrJ. 1, p. 95-100 6 p.

  Research output: Contribution to journal › Article › peer-review

  • X-Ray Diffraction
  • Crystals
  • X ray diffraction
  • Proteins
  • proteins
  59 Scopus citations

• Femtosecond X-ray protein nanocrystallography

  Chapman, H. N., Fromme, P., Barty, A., White, T. A., Kirian, R., Aquila, A., Hunter, M. S., Schulz, J., Deponte, D. P., Weierstall, U., Doak, R. B., Maia, F. R. N. C., Martin, A. V., Schlichting, I., Lomb, L., Coppola, N., Shoeman, R. L., Epp, S. W., Hartmann, R., Rolles, D. & 68 others, Rudenko, A., Foucar, L., Kimmel, N., Weidenspointner, G., Holl, P., Liang, M., Barthelmess, M., Caleman, C., Boutet, S., Bogan, M. J., Krzywinski, J., Bostedt, C., Bajt, S., Gumprecht, L., Rudek, B., Erk, B., Schmidt, C., Hömke, A., Reich, C., Pietschner, D., Ströder, L., Hauser, G., Gorke, H., Ullrich, J., Herrmann, S., Schaller, G., Schopper, F., Soltau, H., Kühnel, K. U., Messerschmidt, M., Bozek, J. D., Hau-Riege, S. P., Frank, M., Hampton, C. Y., Sierra, R. G., Starodub, D., Williams, G. J., Hajdu, J., Timneanu, N., Seibert, M. M., Andreasson, J., Rocker, A., Jönsson, O., Svenda, M., Stern, S., Nass, K., Andritschke, R., Schröter, C. D., Krasniqi, F., Bott, M., Schmidt, K., Wang, X., Grotjohann, I., Holton, J. M., Barends, T. R. M., Neutze, R., Marchesini, S., Fromme, R., Schorb, S., Rupp, D., Adolph, M., Gorkhover, T., Andersson, I., Hirsemann, H., Potdevin, G., Graafsma, H., Nilsson, B. & Spence, J., Feb 3 2011, In: Nature. 470, 7332, p. 73-78 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Photosystem I Protein Complex
  • Nanoparticles
  • X-Rays
  • Radiation
  • Membrane Proteins
  1356 Scopus citations

• High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

  Boutet, S., Lomb, L., Williams, G. J., Barends, T. R. M., Aquila, A., Doak, R. B., Weierstall, U., DePonte, D. P., Steinbrener, J., Shoeman, R. L., Messerschmidt, M., Barty, A., White, T. A., Kassemeyer, S., Kirian, R., Seibert, M. M., Montanez, P. A., Kenney, C., Herbst, R., Hart, P. & 34 others, Pines, J., Haller, G., Gruner, S. M., Philipp, H. T., Tate, M. W., Hromalik, M., Koerner, L. J., Van Bakel, N., Morse, J., Ghonsalves, W., Arnlund, D., Bogan, M. J., Caleman, C., Fromme, R., Hampton, C. Y., Hunter, M. S., Johansson, L. C., Katona, G., Kupitz, C., Liang, M., Martin, A. V., Nass, K., Redecke, L., Stellato, F., Timneanu, N., Wang, D., Zatsepin, N., Schafer, D., Defever, J., Neutze, R., Fromme, P., Spence, J., Chapman, H. N. & Schlichting, I., Jul 20 2012, In: Science. 337, 6092, p. 362-364 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Crystallography
  • X-Rays
  • Synchrotrons
  • Muramidase
  • Lasers
  566 Scopus citations

• High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source

  Martin-Garcia, J. M., Zhu, L., Mendez, D., Lee, M. Y., Chun, E., Li, C., Hu, H., Subramanian, G., Kissick, D., Ogata, C., Henning, R., Ishchenko, A., Dobson, Z., Zhang, S., Weierstall, U., Spence, J. C. H., Fromme, P., Zatsepin, N. A., Fischetti, R. F., Cherezov, V. & 1 others, Liu, W., 2019, In: IUCrJ. 6, p. 412-425 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microcrystals
  • Crystallography
  • Synchrotron radiation
  • Synchrotrons
  • microcrystals
  13 Scopus citations

• Hollow cone illumination for fast TEM, and outrunning damage with electrons

  Spence, J., Subramanian, G. & Musumeci, P., Sep 23 2015, In: Journal of Physics B: Atomic, Molecular and Optical Physics. 48, 21, 214003.

  Research output: Contribution to journal › Article › peer-review

  • hollow
  • cones
  • illumination
  • damage
  • transmission electron microscopy
  13 Scopus citations

• In situ EELS study of dehydration of Al(OH)₃ by electron beam irradiation

  Jiang, N. & Spence, J., Jun 1 2011, In: Ultramicroscopy. 111, 7, p. 860-864 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Electron energy loss spectroscopy
  • Dehydration
  • dehydration
  • Electron beams
  • Irradiation
  14 Scopus citations

• In vivo protein crystallization opens new routes in structural biology

  Koopmann, R., Cupelli, K., Redecke, L., Nass, K., Deponte, D. P., White, T. A., Stellato, F., Rehders, D., Liang, M., Andreasson, J., Aquila, A., Bajt, S., Barthelmess, M., Barty, A., Bogan, M. J., Bostedt, C., Boutet, S., Bozek, J. D., Caleman, C., Coppola, N. & 49 others, Davidsson, J., Doak, R. B., Ekeberg, T., Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Graafsma, H., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, A., Hartmann, R., Hauser, G., Hirsemann, H., Holl, P., Hunter, M. S., Kassemeyer, S., Kirian, R., Lomb, L., Maia, F. R. N. C., Kimmel, N., Martin, A. V., Messerschmidt, M., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Schlichting, I., Schulz, J., Seibert, M. M., Shoeman, R. L., Sierra, R. G., Soltau, H., Stern, S., Strülder, L., Timneanu, N., Ullrich, J., Wang, X., Weidenspointner, G., Weierstall, U., Williams, G. J., Wunderer, C. B., Fromme, P., Spence, J., Stehle, T., Chapman, H. N., Betzel, C. & Duszenko, M., Mar 2012, In: Nature Methods. 9, 3, p. 259-262 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Crystallography
  • Trypanosoma brucei brucei
  • Crystallization
  • Systems Biology
  • Crystals
  133 Scopus citations

• Lawrence Bragg, microdiffraction and X-ray lasers

  Spence, J., 2013, In: Acta Crystallographica Section A: Foundations of Crystallography. 69, 1, p. 25-33 9 p.

  Research output: Contribution to journal › Article › peer-review

  • X ray lasers
  • Electrons
  • Proteins
  • X rays
  • X ray microscopes
  5 Scopus citations

• Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

  Weierstall, U., James, D., Wang, C., White, T. A., Wang, D., Liu, W., Spence, J., Bruce Doak, R., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N., Liu, H., Basu, S., Wacker, D., Won Han, G., Katritch, V., Boutet, S. & 17 others, Messerschmidt, M., Williams, G. J., Koglin, J. E., Marvin Seibert, M., Klinker, M., Gati, C., Shoeman, R. L., Barty, A., Chapman, H. N., Kirian, R., Beyerlein, K. R., Stevens, R. C., Li, D., Shah, S. T. A., Howe, N., Caffrey, M. & Cherezov, V., Feb 14 2014, In: Nature communications. 5, 3309.

  Research output: Contribution to journal › Article › peer-review

  • Crystallography
  • crystallography
  • injectors
  • Microcrystals
  • Smoothened Receptor
  345 Scopus citations

• Lipidic cubic phase serial millisecond crystallography using synchrotron radiation

  Nogly, P., James, D., Wang, D., White, T. A., Zatsepin, N., Shilova, A., Nelson, G., Liu, H., Johansson, L., Heymann, M., Jaeger, K., Metz, M., Wickstrand, C., Wu, W., Båth, P., Berntsen, P., Oberthuer, D., Panneels, V., Cherezov, V., Chapman, H. & 7 others, Schertler, G., Neutze, R., Spence, J., Moraes, I., Burghammer, M., Standfuss, J. & Weierstall, U., Feb 26 2015, In: IUCrJ. 2, p. 168-176 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Bacteriorhodopsins
  • Crystallography
  • Synchrotron radiation
  • Synchrotrons
  • crystallography
  130 Scopus citations

• Lipidic phase membrane protein serial femtosecond crystallography

  Johansson, L. C., Arnlund, D., White, T. A., Katona, G., Deponte, D. P., Weierstall, U., Doak, R. B., Shoeman, R. L., Lomb, L., Malmerberg, E., Davidsson, J., Nass, K., Liang, M., Andreasson, J., Aquila, A., Bajt, S., Barthelmess, M., Barty, A., Bogan, M. J., Bostedt, C. & 48 others, Bozek, J. D., Caleman, C., Coffee, R., Coppola, N., Ekeberg, T., Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Graafsma, H., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, R., Hartmann, A., Hauser, G., Hirsemann, H., Holl, P., Hunter, M. S., Kassemeyer, S., Kimmel, N., Kirian, R., Maia, F. R. N. C., Marchesini, S., Martin, A. V., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Schlichting, I., Schulz, J., Seibert, M. M., Sierra, R. G., Soltau, H., Starodub, D., Stellato, F., Stern, S., Strülder, L., Timneanu, N., Ullrich, J., Wahlgren, W. Y., Wang, X., Weidenspointner, G., Wunderer, C., Fromme, P., Chapman, H. N., Spence, J. & Neutze, R., Mar 2012, In: Nature Methods. 9, 3, p. 263-265 3 p.

  Research output: Contribution to journal › Article › peer-review

  • X ray lasers
  • Free electron lasers
  • Crystallography
  • Porifera
  • Photosynthetic Reaction Center Complex Proteins
  124 Scopus citations

• Mapping the continuous reciprocal space intensity distribution of X-ray serial crystallography

  Yefanov, O., Gati, C., Bourenkov, G., Kirian, R., White, T. A., Spence, J., Chapman, H. N. & Barty, A., Jul 17 2014, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130333.

  Research output: Contribution to journal › Article › peer-review

  • X ray lasers
  • X ray crystallography
  • Free electron lasers
  • Crystallography
  • crystallography
  23 Scopus citations

• Membrane protein megahertz crystallography at the European XFEL

  Gisriel, C., Coe, J., Letrun, R., Yefanov, O. M., Luna-Chavez, C., Stander, N. E., Lisova, S., Mariani, V., Kuhn, M., Aplin, S., Grant, T. D., Dörner, K., Sato, T., Echelmeier, A., Cruz Villarreal, J., Hunter, M. S., Wiedorn, M. O., Knoska, J., Mazalova, V., Roy-Chowdhury, S. & 58 others, Yang, J. H., Jones, A., Bean, R., Bielecki, J., Kim, Y., Mills, G., Weinhausen, B., Meza, J. D., Al-Qudami, N., Bajt, S., Brehm, G., Botha, S., Boukhelef, D., Brockhauser, S., Bruce, B. D., Coleman, M. A., Danilevski, C., Discianno, E., Dobson, Z., Fangohr, H., Martin-Garcia, J. M., Gevorkov, Y., Hauf, S., Hosseinizadeh, A., Januschek, F., Ketawala, G. K., Kupitz, C., Maia, L., Manetti, M., Messerschmidt, M., Michelat, T., Mondal, J., Ourmazd, A., Previtali, G., Sarrou, I., Schön, S., Schwander, P., Shelby, M. L., Silenzi, A., Sztuk-Dambietz, J., Szuba, J., Turcato, M., White, T. A., Wrona, K., Xu, C., Abdellatif, M. H., Zook, J. D., Spence, J. C. H., Chapman, H. N., Barty, A., Kirian, R. A., Frank, M., Ros, A., Schmidt, M., Fromme, R., Mancuso, A. P., Fromme, P. & Zatsepin, N. A., Dec 1 2019, In: Nature communications. 10, 1, 5021.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • X ray lasers
  • Free electron lasers
  • Crystallography
  • crystallography
  • free electron lasers
  8 Scopus citations

• Microfluidic sorting of protein nanocrystals by size for X-ray free-electron laser diffraction

  Abdallah, B. G., Zatsepin, N., Roy-Chowdhury, S., Coe, J., Conrad, C. E., Dörner, K., Sierra, R. G., Stevenson, H. P., Camacho-Alanis, F., Grant, T. D., Nelson, G., James, D., Calero, G., Wachter, R., Spence, J., Weierstall, U., Fromme, P. & Ros, A., Jul 1 2015, In: Structural Dynamics. 2, 4, 041719.

  Research output: Contribution to journal › Article › peer-review

  • X ray lasers
  • Free electron lasers
  • Nanocrystals
  • classifying
  • Diffraction
  13 Scopus citations

• Natively inhibited trypanosoma brucei cathepsin B structure determined by using an x-ray laser

  Redecke, L., Nass, K., DePonte, D. P., White, T. A., Rehders, D., Barty, A., Stellato, F., Liang, M., Barends, T. R. M., Boutet, S., Williams, G. J., Messerschmidt, M., Seibert, M. M., Aquila, A., Arnlund, D., Bajt, S., Barth, T. B., Bogan, M. J., Caleman, C., Chao, T. C. & 29 others, Doak, R. B., Fleckenstein, H., Frank, M., Fromme, R., Galli, L., Grotjohann, I., Hunter, M. S., Johansson, L. C., Kassemeyer, S., Katona, G., Kirian, R., Koopmann, R., Kupitz, C., Lomb, L., Martin, A. V., Mogk, S., Neutze, R., Shoeman, R. L., Steinbrener, J., Timneanu, N., Wang, D., Weierstall, U., Zatsepin, N., Spence, J., Fromme, P., Schlichting, I., Duszenko, M., Betzel, C. & Chapman, H. N., Jan 11 2013, In: Science. 339, 6116, p. 227-230 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Trypanosoma brucei brucei
  • Cysteine Proteases
  • Lasers
  • X-Rays
  • Crystallography
  319 Scopus citations

• New directions in X-ray microscopy

  Falcone, R., Jacobsen, C., Kirz, J., Marchesini, S., Shapiro, D. & Spence, J., Jul 1 2011, In: Contemporary Physics. 52, 4, p. 293-318 26 p.

  Research output: Contribution to journal › Article › peer-review

  • microscopy
  • x rays
  • microscopes
  • high resolution
  • geometrical optics
  60 Scopus citations