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  • Douglas McFadden
Article

The Curious Road from Basic Pathogen Research to Clinical Translation

McFadden, G., Jun 1 2015, In : PLoS Pathogens. 11, 6, e1004997.

Research output: Contribution to journalArticle

1 Scopus citations

The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells

Jeng, D., Ma, Z., Barrett, J. W., McFadden, G., Loeb, J. A. & Essania, K., Mar 2013, In : Journal of virology. 87, 6, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

The wide utility of rabbits as models of human diseases

Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., González-Gallego, J., Giacani, L., Hu, J., Kaplan, G., Keppler, O. T., Knight, K. L., Kong, X. P., Lanning, D. K., Le Pendu, J., De Matos, A. L., Liu, J., Liu, S., Lopes, A. M., Lu, S. & 17 others, Lukehart, S., Manabe, Y. C., Neves, F., McFadden, D., Pan, R., Peng, X., de Sousa-Pereira, P., Pinheiro, A., Rahman, M., Ruvoën-Clouet, N., Subbian, S., Tuñón, M. J., van der Loo, W., Vaine, M., Via, L. E., Wang, S. & Mage, R., May 2018, In : Experimental and Molecular Medicine. 50, 5, 66.

Research output: Contribution to journalArticle

24 Scopus citations

The α2,3-sialyltransferase encoded by myxoma virus is a virulence factor that contributes to immunosuppression

Boutard, B., Vankerckhove, S., Markine-Goriaynoff, N., Sarlet, M., Desmecht, D., McFadden, G., Vanderplasschen, A. & Gillet, L., Feb 23 2015, In : PloS one. 10, 2, e0118806.

Research output: Contribution to journalArticle

4 Scopus citations

Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin

Zemp, F. J., Lun, X., McKenzie, B. A., Zhou, H., Maxwell, L., Sun, B., Kelly, J. J. P., Stechishin, O., Luchman, A., Weiss, S., Cairncross, J. G., Hamilton, M. G., Rabinovich, B. A., Rahman, M. M., Mohamed, M. R., Smallwood, S., Senger, D. L., Bell, J., McFadden, G. & Forsyth, P. A., Jul 2013, In : Neuro-Oncology. 15, 7, p. 904-920 17 p.

Research output: Contribution to journalArticle

24 Scopus citations

Tumor necrosis factor inhibitors from poxviruses with an emphasis on tanapoxvirus-2L protein

Jeng, D., Rahman, M. M., McFadden, G. & Essani, K., Aug 1 2011, In : Recent Patents on DNA and Gene Sequences. 5, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Viral anti-inflammatory proteins target diverging immune pathways with converging effects on arterial dilatation, plaque and apoptosis

Davids, J. A., Dai, E., Chen, H., Bartee, M. Y., Liu, L., Fortunel, A., Moyer, R., Mcfadden, G. & Lucas, A. R., Jan 1 2014, In : European Journal of Inflammation. 12, 1, p. 131-145 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Viral serpin therapeutics: From concept to clinic

Chen, H., Zheng, D., Davids, J., Bartee, M. Y., Dai, E., Liu, L., Petrov, L., Macaulay, C., Thoburn, R., Sobel, E., Moyer, R., McFadden, D. & Lucas, A., Jun 24 2011, In : Methods in Enzymology. 499, p. 301-329 29 p.

Research output: Contribution to journalArticle

17 Scopus citations

Virotherapy using Myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells

Bartee, E., Meacham, A., Wise, E., Cogle, C. R. & McFadden, G., Aug 14 2012, In : PloS one. 7, 8, e43298.

Research output: Contribution to journalArticle

11 Scopus citations

White paper on microbial anti-cancer therapy and prevention

Forbes, N. S., Coffin, R. S., Deng, L., Evgin, L., Fiering, S., Giacalone, M., Gravekamp, C., Gulley, J. L., Gunn, H., Hoffman, R. M., Kaur, B., Liu, K., Lyerly, H. K., Marciscano, A. E., Moradian, E., Ruppel, S., Saltzman, D. A., Tattersall, P. J., Thorne, S., Vile, R. G. & 3 others, Zhang, H. H., Zhou, S. & McFadden, D., Aug 6 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 78.

Research output: Contribution to journalArticle

18 Scopus citations
Chapter

Serpins: Development for therapeutic applications

Lucas, A., Yaron, J. R., Zhang, L., Macaulay, C. & McFadden, D., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 255-265 11 p. (Methods in Molecular Biology; vol. 1826).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Serpins, viruses, and the virome: New directions in therapy

Ambadapadi, S., Chen, H., Zheng, D., Liu, L., Dai, E., Munuswamy-Ramanujam, G., Morshed, S., Fuentes, J., Fortunel, A., Al-Ani, M., Kesavalu, L., McFadden, D. & Lucas, A., Jan 1 2015, The Serpin Family: Proteins with Multiple Functions in Health and Disease. Springer International Publishing, p. 293-329 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
Comment/debate

Author Correction: The wide utility of rabbits as models of human diseases (Experimental & Molecular Medicine, (2018), 50, 5, (66), 10.1038/s12276-018-0094-1)

Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., González-Gallego, J., Giacani, L., Hu, J., Kaplan, G., Keppler, O. T., Knight, K. L., Kong, X. P., Lanning, D. K., Le Pendu, J., de Matos, A. L., Liu, J., Liu, S., Lopes, A. M., Lu, S. & 17 others, Lukehart, S., Manabe, Y. C., Neves, F., McFadden, G., Pan, R., Peng, X., de Sousa-Pereira, P., Pinheiro, A., Rahman, M., Ruvoën-Clouet, N., Subbian, S., Tuñón, M. J., van der Loo, W., Vaine, M., Via, L. E., Wang, S. & Mage, R., Jul 1 2019, In : Experimental and Molecular Medicine. 51, 7, 71.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/Myd88-, IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Dec 2011, In : Journal of virology. 85, 23, p. 12835 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
Editorial

Building bridges between plant and animal viruses

McFadden, G. & Simon, A. E., Nov 2011, In : Current opinion in virology. 1, 5, p. 319-321 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Editorial overview: Oncolytic viruses - Replicating virus therapeutics for the treatment of cancer

Bell, J. C. & McFadden, D., Aug 22 2015, In : Current Opinion in Virology. 13, p. viii-ix

Research output: Contribution to journalEditorial

8 Scopus citations

Introducing “Research Matters”

McFadden, G. & Haldar, K., Jun 1 2015, In : PLoS Pathogens. 11, 6, e1005014.

Research output: Contribution to journalEditorial

The virome: Viral ghost companion, virus wars

Lucas, A., Ambadapadi, S., Zheng, D., Chen, H., Lakshmyya, K., Progulske-Fox, A., Krafft, A., Bryant, M., O’Regan, S., Moyer, R., McFadden, G., Jobin, C. & Rand, K., Jan 1 2014, In : Journal of Clinical and Experimental Cardiology. 5, 8, e136.

Research output: Contribution to journalEditorial

1 Scopus citations

Women in cardiology: The x factor and the heart of medicine

Lucas, A., Eaverly, M., McFadden, G. & Bryant, M., Feb 2014, In : Journal of Clinical and Experimental Cardiology. 5, 2

Research output: Contribution to journalEditorial

Review article

Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?

Yaron, J. R., Kwiecien, J. M., Zhang, L., Ambadapadi, S., Wakefield, D. N., Clapp, W. L., Dabrowski, W., Burgin, M., Munk, B. H., McFadden, G., Chen, H. & Lucas, A. R., Jul 2019, In : Trends in Molecular Medicine. 25, 7, p. 626-639 14 p.

Research output: Contribution to journalReview article

Modulation of NF-κB signalling by microbial pathogens

Rahman, M. M. & McFadden, G., Apr 2011, In : Nature Reviews Microbiology. 9, 4, p. 291-306 16 p.

Research output: Contribution to journalReview article

179 Scopus citations

Oncolytic virotherapy for hematological malignancies

Bais, S., Bartee, E., Rahman, M. M., McFadden, G. & Cogle, C. R., 2012, In : Advances in Virology. 2012, 186512.

Research output: Contribution to journalReview article

23 Scopus citations

Oncolytic virotherapy for pancreatic cancer.

Wennier, S., Li, S. & McFadden, G., 2011, In : Expert reviews in molecular medicine. 13, p. e18

Research output: Contribution to journalReview article

23 Scopus citations

Poxviruses and the evolution of host range and virulence

Haller, S. L., Peng, C., McFadden, G. & Rothenburg, S., Jan 2014, In : Infection, Genetics and Evolution. 21, p. 15-40 26 p.

Research output: Contribution to journalReview article

83 Scopus citations

Poxvirus oncolytic virotherapy

Torres-Domínguez, L. E. & McFadden, G., Jun 3 2019, In : Expert Opinion on Biological Therapy. 19, 6, p. 561-573 13 p.

Research output: Contribution to journalReview article

5 Scopus citations

The current status and future directions of myxoma virus, a master in immune evasion

Spiesschaert, B., McFadden, G., Hermans, K., Nauwynck, H. & Van De Walle, G. R., 2011, In : Veterinary Research. 42, 1, 76.

Research output: Contribution to journalReview article

28 Scopus citations

The poxvirus C7L host range factor superfamily

Liu, J., Rothenburg, S. & McFadden, G., Dec 2012, In : Current opinion in virology. 2, 6, p. 764-772 9 p.

Research output: Contribution to journalReview article

11 Scopus citations

The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation

Chen, H., Davids, J. A., Zheng, D., Bryant, M., Bot, I., van Berckel, T. J. C., Biessen, E., Pepine, C., Ryman, K., Progulski-Fox, A., Kesavalu, L., Moyer, R., McFadden, G. & Lucas, A., Jan 1 2013, In : Cardiovascular and Hematological Disorders - Drug Targets. 13, 2, p. 99-110 12 p.

Research output: Contribution to journalReview article

10 Scopus citations

Virotherapy as Potential Adjunct Therapy for Graft-Vs-Host Disease

Villa, N. Y. & McFadden, G., Dec 1 2018, In : Current Pathobiology Reports. 6, 4, p. 247-263 17 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Viruses for tumor therapy

Bell, J. & McFadden, G., Mar 12 2014, In : Cell Host and Microbe. 15, 3, p. 260-265 6 p.

Research output: Contribution to journalReview article

75 Scopus citations