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  • Douglas McFadden

Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro

Madlambayan, G. J., Bartee, E., Kim, M., Rahman, M. M., Meacham, A., Scott, E. W., McFadden, G. & Cogle, C. R., May 1 2012, In : Leukemia Research. 36, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Are We There Yet? The Smallpox Research Agenda Using Variola Virus

Damon, I. K., Damaso, C. R. & McFadden, G., May 2014, In : PLoS Pathogens. 10, 5, e1004108.

Research output: Contribution to journalArticle

14 Scopus citations

Author Correction: The wide utility of rabbits as models of human diseases (Experimental & Molecular Medicine, (2018), 50, 5, (66), 10.1038/s12276-018-0094-1)

Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., González-Gallego, J., Giacani, L., Hu, J., Kaplan, G., Keppler, O. T., Knight, K. L., Kong, X. P., Lanning, D. K., Le Pendu, J., de Matos, A. L., Liu, J., Liu, S., Lopes, A. M., Lu, S. & 17 others, Lukehart, S., Manabe, Y. C., Neves, F., McFadden, G., Pan, R., Peng, X., de Sousa-Pereira, P., Pinheiro, A., Rahman, M., Ruvoën-Clouet, N., Subbian, S., Tuñón, M. J., van der Loo, W., Vaine, M., Via, L. E., Wang, S. & Mage, R., Jul 1 2019, In : Experimental and Molecular Medicine. 51, 7, 71.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Bugs and drugs: Oncolytic virotherapy in combination with chemotherapy

Wennier, S. T., Liu, J. & McFadden, G., Jul 1 2012, In : Current Pharmaceutical Biotechnology. 13, 9, p. 1817-1833 17 p.

Research output: Contribution to journalArticle

33 Scopus citations

Building bridges between plant and animal viruses

McFadden, G. & Simon, A. E., Nov 2011, In : Current opinion in virology. 1, 5, p. 319-321 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus

Zemp, F. J., McKenzie, B. A., Lun, X., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Dec 15 2014, In : Cancer Research. 74, 24, p. 7260-7273 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Coinfections of novel polyomavirus, anelloviruses and a recombinant strain of myxoma virus-MYXV-tol identified in Iberian hares

Ägueda-Pinto, A., Kraberger, S., Lund, M. C., Gortázar, C., McFadden, G., Varsani, A. & Esteves, P. J., Jan 1 2020, In : Viruses. 12, 3, 340.

Research output: Contribution to journalArticle

Open Access

Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function

Mahon, B. P., Ambadapadi, S., Yaron, J. R., Lomelino, C. L., Pinard, M. A., Keinan, S., Kurnikov, I., Macaulay, C., Zhang, L., Reeves, W., McFadden, D., Tibbetts, S., McKenna, R. & Lucas, A. R., Feb 20 2018, In : Biochemistry. 57, 7, p. 1096-1107 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cytokine synergy: An underappreciated contributor to innate anti-viral immunity

Bartee, E. & McFadden, G., Sep 1 2013, In : Cytokine. 63, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Editorial overview: Oncolytic viruses - Replicating virus therapeutics for the treatment of cancer

Bell, J. C. & McFadden, D., Aug 22 2015, In : Current Opinion in Virology. 13, p. viii-ix

Research output: Contribution to journalEditorial

6 Scopus citations

Evidence for differential viral oncolytic efficacy in an in vitro model of epithelial ovarian cancer metastasis

Tong, J. G., Valdes, Y. R., Barrett, J. W., Bell, J. C., Stojdl, D., McFadden, G., McCart, J. A., DiMattia, G. E. & Shepherd, T. G., Sep 23 2015, In : Molecular Therapy - Oncolytics. 2, 1 p., 15013.

Research output: Contribution to journalArticle

14 Scopus citations

Evolution and divergence of the mammalian SAMD9/SAMD9L gene family

Lemos De Matos, A., Liu, J., McFadden, G. & Esteves, P. J., Jun 17 2013, In : BMC Evolutionary Biology. 13, 1, 121.

Research output: Contribution to journalArticle

22 Scopus citations

Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Jan 1 2014, In : Immunogenetics. 66, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor

Lilly, C. L., Villa, N., Lemos de Matos, A., Ali, H. M., Dhillon, J. K. S., Hofland, T., Rahman, M., Chan, W., Bogen, B., Cogle, C. & McFadden, D., Mar 1 2017, In : Molecular Therapy - Oncolytics. 4, p. 31-40 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ex vivo virotherapy with myxoma virus does not impair hematopoietic stem and progenitor cells

Villa, N., Bais, S., Chan, W. M., Meacham, A. M., Wise, E., Rahman, M., Moreb, J. S., Rosenau, E. H., Wingard, J. R., McFadden, D. & Cogle, C. R., Mar 1 2016, In : Cytotherapy. 18, 3, p. 465-480 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Ex Vivo Virotherapy with Myxoma Virus to Treat Cancer

Villa, N. Y., Franco, L. S. & McFadden, G., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 95-110 16 p. (Methods in Molecular Biology; vol. 2058).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation

Ildefonso, C. J., Jaime, H., Rahman, M. M., Li, Q., Boye, S. E., Hauswirth, W. W., Lucas, A. R., McFadden, G. & Lewin, A. S., Jan 1 2015, In : Human Gene Therapy. 26, 1, p. 59-68 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetic characterization of a recombinant myxoma virus in the iberian hare (Lepus granatensis)

Águeda-Pinto, A., Matos, A. L. D., Abrantes, M., Kraberger, S., Risalde, M. A., Gortázar, C., McFadden, G., Varsani, A. & Esteves, P. J., Jun 2019, In : Viruses. 11, 6, 530.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Genome characterization of cetaceanpox virus from a managed Indo-Pacific bottlenose dolphin (Tursiops aduncus)

Rodrigues, T. C. S., Subramaniam, K., Varsani, A., McFadden, G., Schaefer, A. M., Bossart, G. D., Romero, C. H. & Waltzek, T. B., Mar 2020, In : Virus research. 278, 197861.

Research output: Contribution to journalArticle

Identification of host DEAD-box RNA helicases that regulate cellular tropism of oncolytic Myxoma virus in human cancer cells

Rahman, M., Bagdassarian, E., Ali, M. A. M. & McFadden, D., Dec 1 2017, In : Scientific reports. 7, 1, 15710.

Research output: Contribution to journalArticle

7 Scopus citations

Innate immune response of human Plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain

Cao, H., Dai, P., Wang, W., Li, H., Yuan, J., Wang, F., Fang, C. M., Pitha, P. M., Liu, J., Condit, R. C., McFadden, G., Merghoub, T., Houghton, A. N., Young, J. W., Shuman, S. & Deng, L., May 14 2012, In : PloS one. 7, 5, e36823.

Research output: Contribution to journalArticle

15 Scopus citations

Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells

France, M. R., Thomas, D. L., Liu, J., McFadden, G., MacNeill, A. L. & Roy, E. J., Jan 1 2011, In : Journal of General Virology. 92, 1, p. 195-199 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Introducing “Research Matters”

McFadden, D. & Haldar, K., Jan 1 2015, In : PLoS Pathogens. 11, 6, e1005014.

Research output: Contribution to journalEditorial

In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells

McKenzie, B. A., Zemp, F. J., Pisklakova, A., Narendran, A., McFadden, D., Lun, X., Kenchappa, R. S., Kurz, E. U. & Forsyth, P. A., Jan 1 2015, In : Neuro-Oncology. 17, 8, p. 1086-1094 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

Pisklakova, A., McKenzie, B., Zemp, F., Lun, X., Kenchappa, R. S., Etame, A. B., Rahman, M., Reilly, K., Pilon-Thomas, S., McFadden, D., Kurz, E. & Forsyth, P. A., Aug 1 2016, In : Neuro-Oncology. 18, 8, p. 1088-1098 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells

Liu, J., Wennier, S., Zhang, L. & McFadden, G., Apr 1 2011, In : Journal of virology. 85, 7, p. 3270-3282 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Mesenchymal stem cells as carriers for systemic delivery of oncolytic viruses

Hadryś, A., Sochanik, A., McFadden, G. & Jazowiecka-Rakus, J., May 5 2020, In : European Journal of Pharmacology. 874, 172991.

Research output: Contribution to journalReview article

Open Access

Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?

Yaron, J. R., Kwiecien, J. M., Zhang, L., Ambadapadi, S., Wakefield, D. N., Clapp, W. L., Dabrowski, W., Burgin, M., Munk, B. H., McFadden, D., Chen, H. & Lucas, A. R., Jan 1 2019, In : Trends in Molecular Medicine.

Research output: Contribution to journalReview article

Modulation of NF-κB signalling by microbial pathogens

Rahman, M. M. & McFadden, G., Apr 1 2011, In : Nature Reviews Microbiology. 9, 4, p. 291-306 16 p.

Research output: Contribution to journalReview article

165 Scopus citations

Myxoma and vaccinia viruses bind differentially to human leukocytes

Chan, W. M., Bartee, E. C., Moreb, J. S., Dower, K., Connor, J. H. & McFadden, G., Apr 1 2013, In : Journal of virology. 87, 8, p. 4445-4460 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Myxomaviral anti-inflammatory serpin reduces myeloid-derived suppressor cells and human pancreatic cancer cell growth in mice

Zheng, D., Chen, H., Bartee, M. Y., Williams, J., Davids, J. A., Lomas, D. A., McFadden, G. & Lucas, A. R., Sep 30 2013, In : Journal of Cancer Science and Therapy. 5, 8, p. 291-299 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

Thomas, D. L., Doty, R., Tosic, V., Liu, J., Kranz, D. M., McFadden, G., MacNeill, A. L. & Roy, E. J., Oct 1 2011, In : Cancer Immunology, Immunotherapy. 60, 10, p. 1461-1472 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection

Chen, H., Zheng, D., Abbott, J., Liu, L., Bartee, M. Y., Long, M., Davids, J., Williams, J., Feldmann, H., Strong, J., Grau, K. R., Tibbetts, S., Macaulay, C., McFadden, G., Thoburn, R., Lomas, D. A., Spinale, F. G., Virgin, H. W. & Lucas, A., Sep 1 2013, In : Antimicrobial Agents and Chemotherapy. 57, 9, p. 4114-4127 14 p.

Research output: Contribution to journalArticle

19 Scopus citations
2 Scopus citations

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PloS one. 9, 10, e109801.

Research output: Contribution to journalArticle

17 Scopus citations

Myxoma virus induces type i interferon production in murine plasmacytoid dendritic cells via a TLR9/myd88-,IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Oct 1 2011, In : Journal of virology. 85, 20, p. 10814-10825 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/Myd88-, IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Dec 1 2011, In : Journal of virology. 85, 23, p. 12835 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Myxoma Virus Infection Promotes NK Lysis of Malignant Gliomas In Vitro and In Vivo

Ogbomo, H., Zemp, F. J., Lun, X., Zhang, J., Stack, D., Rahman, M. M., Mcfadden, G., Mody, C. H. & Forsyth, P. A., Jun 10 2013, In : PloS one. 8, 6, e66825.

Research output: Contribution to journalArticle

23 Scopus citations
35 Scopus citations

Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs

Garg, R. R., Jackson, C. B., Rahman, M. M., Khan, A. R., Lewin, A. S. & McFadden, G., May 24 2019, In : Journal of Biological Chemistry. 294, 21, p. 8480-8489 10 p.

Research output: Contribution to journalArticle

Myxoma virus M064 Is a novel member of the poxvirus C7l superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits

Liu, J., Wennier, S., Moussatche, N., Reinhard, M., Condit, R. & McFadden, G., May 1 2012, In : Journal of virology. 86, 9, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
21 Scopus citations

Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity

Correa, R. J. M., Komar, M., Tong, J. G. K., Sivapragasam, M., Rahman, M. M., McFadden, G., Dimattia, G. E. & Shepherd, T. G., May 1 2012, In : Gynecologic Oncology. 125, 2, p. 441-450 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
29 Scopus citations

Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer

Wennier, S. T., Liu, J., Li, S., Rahman, M. M., Mona, M. & McFadden, G., Apr 2012, In : Molecular Therapy. 20, 4, p. 759-768 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells

Villa, N., Wasserfall, C. H., Meacham, A. M., Wise, E., Chan, W., Wingard, J. R., McFadden, D. & Cogle, C. R., Jun 11 2015, In : Blood. 125, 24, p. 3778-3788 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps

Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G. & Kubes, P., Feb 13 2013, In : Cell Host and Microbe. 13, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

182 Scopus citations

Oncolytic myxoma virus: The path to clinic

Chan, W. M., Rahman, M. M. & McFadden, G., Sep 6 2013, In : Vaccine. 31, 39, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Oncolytic poxviruses

Chan, W. M. & McFadden, D., Sep 29 2014, In : Annual Review of Virology. 1, 1, p. 191-214 24 p.

Research output: Contribution to journalArticle

46 Scopus citations

Oncolytic virotherapy for hematological malignancies

Bais, S., Bartee, E., Rahman, M. M., McFadden, G. & Cogle, C. R., Dec 1 2012, In : Advances in Virology. 2012, 186512.

Research output: Contribution to journalReview article

21 Scopus citations