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  • Douglas McFadden
2011

Building bridges between plant and animal viruses

McFadden, G. & Simon, A. E., Nov 2011, In : Current opinion in virology. 1, 5, p. 319-321 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells

France, M. R., Thomas, D. L., Liu, J., McFadden, G., MacNeill, A. L. & Roy, E. J., Jan 1 2011, In : Journal of General Virology. 92, 1, p. 195-199 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells

Liu, J., Wennier, S., Zhang, L. & McFadden, G., Apr 1 2011, In : Journal of virology. 85, 7, p. 3270-3282 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Modulation of NF-κB signalling by microbial pathogens

Rahman, M. M. & McFadden, G., Apr 1 2011, In : Nature Reviews Microbiology. 9, 4, p. 291-306 16 p.

Research output: Contribution to journalReview article

169 Scopus citations

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

Thomas, D. L., Doty, R., Tosic, V., Liu, J., Kranz, D. M., McFadden, G., MacNeill, A. L. & Roy, E. J., Oct 1 2011, In : Cancer Immunology, Immunotherapy. 60, 10, p. 1461-1472 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Myxoma virus induces type i interferon production in murine plasmacytoid dendritic cells via a TLR9/myd88-,IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Oct 1 2011, In : Journal of virology. 85, 20, p. 10814-10825 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/Myd88-, IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Dec 1 2011, In : Journal of virology. 85, 23, p. 12835 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
35 Scopus citations

Oncolytic virotherapy for pancreatic cancer.

Wennier, S., Li, S. & McFadden, G., Oct 7 2011, In : Expert reviews in molecular medicine. 13, p. e18

Research output: Contribution to journalReview article

22 Scopus citations

Production of myxoma virus gateway entry and expression libraries and validation of viral protein expression

Smallwood, S. E., Rahman, M. M., Werden, S. J., Martino, M. F. & McFadden, G., Aug 29 2011, In : Current Protocols in Microbiology. SUPPL.21

Research output: Contribution to journalArticle

2 Scopus citations

The current status and future directions of myxoma virus, a master in immune evasion

Spiesschaert, B., McFadden, G., Hermans, K., Nauwynck, H. & Van De Walle, G. R., Aug 29 2011, In : Veterinary Research. 42, 1, 76.

Research output: Contribution to journalReview article

28 Scopus citations

Tumor necrosis factor inhibitors from poxviruses with an emphasis on tanapoxvirus-2L protein

Jeng, D., Rahman, M. M., McFadden, G. & Essani, K., Aug 1 2011, In : Recent Patents on DNA and Gene Sequences. 5, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Viral serpin therapeutics: From concept to clinic

Chen, H., Zheng, D., Davids, J., Bartee, M. Y., Dai, E., Liu, L., Petrov, L., Macaulay, C., Thoburn, R., Sobel, E., Moyer, R., McFadden, D. & Lucas, A., Jun 24 2011, In : Methods in Enzymology. 499, p. 301-329 29 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro

Madlambayan, G. J., Bartee, E., Kim, M., Rahman, M. M., Meacham, A., Scott, E. W., McFadden, G. & Cogle, C. R., May 1 2012, In : Leukemia Research. 36, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Bugs and drugs: Oncolytic virotherapy in combination with chemotherapy

Wennier, S. T., Liu, J. & McFadden, G., Jul 1 2012, In : Current Pharmaceutical Biotechnology. 13, 9, p. 1817-1833 17 p.

Research output: Contribution to journalArticle

33 Scopus citations

Innate immune response of human Plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain

Cao, H., Dai, P., Wang, W., Li, H., Yuan, J., Wang, F., Fang, C. M., Pitha, P. M., Liu, J., Condit, R. C., McFadden, G., Merghoub, T., Houghton, A. N., Young, J. W., Shuman, S. & Deng, L., May 14 2012, In : PloS one. 7, 5, e36823.

Research output: Contribution to journalArticle

15 Scopus citations

Myxoma virus M064 Is a novel member of the poxvirus C7l superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits

Liu, J., Wennier, S., Moussatche, N., Reinhard, M., Condit, R. & McFadden, G., May 1 2012, In : Journal of virology. 86, 9, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity

Correa, R. J. M., Komar, M., Tong, J. G. K., Sivapragasam, M., Rahman, M. M., McFadden, G., Dimattia, G. E. & Shepherd, T. G., May 1 2012, In : Gynecologic Oncology. 125, 2, p. 441-450 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer

Wennier, S. T., Liu, J., Li, S., Rahman, M. M., Mona, M. & McFadden, G., Apr 2012, In : Molecular Therapy. 20, 4, p. 759-768 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Oncolytic virotherapy for hematological malignancies

Bais, S., Bartee, E., Rahman, M. M., McFadden, G. & Cogle, C. R., Dec 1 2012, In : Advances in Virology. 2012, 186512.

Research output: Contribution to journalReview article

21 Scopus citations

Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplantation Grafts using Oncolytic Myxoma Virus

Bartee, E., Chan, W. M., Moreb, J. S., Cogle, C. R. & McFadden, G., Oct 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 10, p. 1540-1551 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

The poxvirus C7L host range factor superfamily

Liu, J., Rothenburg, S. & McFadden, G., Dec 2012, In : Current opinion in virology. 2, 6, p. 764-772 9 p.

Research output: Contribution to journalReview article

11 Scopus citations

Virotherapy using Myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells

Bartee, E., Meacham, A., Wise, E., Cogle, C. R. & McFadden, G., Aug 14 2012, In : PloS one. 7, 8, e43298.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Cytokine synergy: An underappreciated contributor to innate anti-viral immunity

Bartee, E. & McFadden, G., Sep 1 2013, In : Cytokine. 63, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Evolution and divergence of the mammalian SAMD9/SAMD9L gene family

Lemos De Matos, A., Liu, J., McFadden, G. & Esteves, P. J., Jun 17 2013, In : BMC Evolutionary Biology. 13, 1, 121.

Research output: Contribution to journalArticle

22 Scopus citations

Myxoma and vaccinia viruses bind differentially to human leukocytes

Chan, W. M., Bartee, E. C., Moreb, J. S., Dower, K., Connor, J. H. & McFadden, G., Apr 1 2013, In : Journal of virology. 87, 8, p. 4445-4460 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Myxomaviral anti-inflammatory serpin reduces myeloid-derived suppressor cells and human pancreatic cancer cell growth in mice

Zheng, D., Chen, H., Bartee, M. Y., Williams, J., Davids, J. A., Lomas, D. A., McFadden, G. & Lucas, A. R., Sep 30 2013, In : Journal of Cancer Science and Therapy. 5, 8, p. 291-299 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection

Chen, H., Zheng, D., Abbott, J., Liu, L., Bartee, M. Y., Long, M., Davids, J., Williams, J., Feldmann, H., Strong, J., Grau, K. R., Tibbetts, S., Macaulay, C., McFadden, G., Thoburn, R., Lomas, D. A., Spinale, F. G., Virgin, H. W. & Lucas, A., Sep 1 2013, In : Antimicrobial Agents and Chemotherapy. 57, 9, p. 4114-4127 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Myxoma Virus Infection Promotes NK Lysis of Malignant Gliomas In Vitro and In Vivo

Ogbomo, H., Zemp, F. J., Lun, X., Zhang, J., Stack, D., Rahman, M. M., Mcfadden, G., Mody, C. H. & Forsyth, P. A., Jun 10 2013, In : PloS one. 8, 6, e66825.

Research output: Contribution to journalArticle

23 Scopus citations
29 Scopus citations

Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps

Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G. & Kubes, P., Feb 13 2013, In : Cell Host and Microbe. 13, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

184 Scopus citations

Oncolytic myxoma virus: The path to clinic

Chan, W. M., Rahman, M. M. & McFadden, G., Sep 6 2013, In : Vaccine. 31, 39, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Positive evolutionary selection on the RIG-I-like receptor genes in mammals

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Nov 27 2013, In : PloS one. 8, 11, e81864.

Research output: Contribution to journalArticle

20 Scopus citations

Resistance to Oncolytic Myxoma Virus Therapy in Nf1-/-/Trp53-/- Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

Zemp, F. J., McKenzie, B. A., Lun, X., Maxwell, L., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Jun 6 2013, In : PloS one. 8, 6, e65801.

Research output: Contribution to journalArticle

10 Scopus citations

The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation

Chen, H., Davids, J. A., Zheng, D., Bryant, M., Bot, I., van Berckel, T. J. C., Biessen, E., Pepine, C., Ryman, K., Progulski-Fox, A., Kesavalu, L., Moyer, R., McFadden, G. & Lucas, A., Jan 1 2013, In : Cardiovascular and Hematological Disorders - Drug Targets. 13, 2, p. 99-110 12 p.

Research output: Contribution to journalReview article

9 Scopus citations

The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells

Jeng, D., Ma, Z., Barrett, J. W., McFadden, G., Loeb, J. A. & Essania, K., Mar 1 2013, In : Journal of virology. 87, 6, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin

Zemp, F. J., Lun, X., McKenzie, B. A., Zhou, H., Maxwell, L., Sun, B., Kelly, J. J. P., Stechishin, O., Luchman, A., Weiss, S., Cairncross, J. G., Hamilton, M. G., Rabinovich, B. A., Rahman, M. M., Mohamed, M. R., Smallwood, S., Senger, D. L., Bell, J., McFadden, G. & Forsyth, P. A., Jul 1 2013, In : Neuro-Oncology. 15, 7, p. 904-920 17 p.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Are We There Yet? The Smallpox Research Agenda Using Variola Virus

Damon, I. K., Damaso, C. R. & McFadden, G., May 2014, In : PLoS Pathogens. 10, 5, e1004108.

Research output: Contribution to journalArticle

14 Scopus citations

Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus

Zemp, F. J., McKenzie, B. A., Lun, X., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Dec 15 2014, In : Cancer Research. 74, 24, p. 7260-7273 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Jan 1 2014, In : Immunogenetics. 66, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PloS one. 9, 10, e109801.

Research output: Contribution to journalArticle

17 Scopus citations

Oncolytic poxviruses

Chan, W. M. & McFadden, D., Sep 29 2014, In : Annual Review of Virology. 1, 1, p. 191-214 24 p.

Research output: Contribution to journalArticle

47 Scopus citations

Poxviruses and the evolution of host range and virulence

Haller, S. L., Peng, C., McFadden, G. & Rothenburg, S., Jan 2014, In : Infection, Genetics and Evolution. 21, p. 15-40 26 p.

Research output: Contribution to journalReview article

81 Scopus citations
6 Scopus citations

Scalable collaborative infrastructure for a learning healthcare system (SCILHS): Architecture

Mandl, K. D., Kohane, I. S., McFadden, D., Weber, G. M., Natter, M., Mandel, J., Schneeweiss, S., Weiler, S., Klann, J. G., Bickel, J., Adams, W. G., Ge, Y., Zhou, X., Perkins, J., Marsolo, K., Berns tam, E., Showalter, J., Quarshie, A., Ofili, E., Hripcsak, G. & 1 others, Murphy, S. N., Jan 1 2014, In : Journal of the American Medical Informatics Association. 21, 4, p. 615-620 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus

Brahn, E., Lee, S., Lucas, A., McFadden, G. & MaCaulay, C., Aug 2014, In : Clinical Immunology. 153, 2, p. 254-263 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting gallbladder cancer: Oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo

Weng, M., Gong, W., Ma, M., Chu, B., Qin, Y., Zhang, M., Lun, X., McFadden, G., Forsyth, P., Yang, Y. & Quan, Z., Apr 13 2014, In : Molecular Cancer. 13, 1, 82.

Research output: Contribution to journalArticle

12 Scopus citations

The virome: Viral ghost companion, virus wars

Lucas, A., Ambadapadi, S., Zheng, D., Chen, H., Lakshmyya, K., Progulske-Fox, A., Krafft, A., Bryant, M., O’Regan, S., Moyer, R., McFadden, G., Jobin, C. & Rand, K., Jan 1 2014, In : Journal of Clinical and Experimental Cardiology. 5, 8, e136.

Research output: Contribution to journalEditorial

1 Scopus citations

Viral anti-inflammatory proteins target diverging immune pathways with converging effects on arterial dilatation, plaque and apoptosis

Davids, J. A., Dai, E., Chen, H., Bartee, M. Y., Liu, L., Fortunel, A., Moyer, R., Mcfadden, G. & Lucas, A. R., Jan 1 2014, In : European Journal of Inflammation. 12, 1, p. 131-145 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Viruses for tumor therapy

Bell, J. & McFadden, G., Mar 12 2014, In : Cell Host and Microbe. 15, 3, p. 260-265 6 p.

Research output: Contribution to journalReview article

71 Scopus citations