Find Scholarly Works

Search concepts
Selected Filters

Publication Year

  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2010

Author

  • Sidney Hecht
2019

Expanding the Scope of Protein Synthesis Using Modified Ribosomes

Dedkova, L. & Hecht, S., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6430-6447 18 p.

Research output: Contribution to journalArticle

4 Scopus citations

In Cellulo Synthesis of Proteins Containing a Fluorescent Oxazole Amino Acid

Chen, S., Ji, X., Gao, M., Dedkova, L. & Hecht, S., Apr 10 2019, In : Journal of the American Chemical Society. 141, 14, p. 5597-5601 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction

Ji, X., Khdour, O. & Hecht, S., Jan 1 2019, In : Future Medicinal Chemistry. 11, 13, p. 1605-1624 20 p.

Research output: Contribution to journalReview article

Selective detection of dengue virus serotypes using tandem toehold-mediated displacement reactions

Gao, M., Waggoner, J. J., Hecht, S. M. & Chen, S., Jan 1 2019, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

2018

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P., Hecht, S. & Khdour, O., Oct 1 2018, In : Data in Brief. 20, p. 1105-1114 10 p.

Research output: Contribution to journalArticle

Lipophilic methylene blue analogues enhance mitochondrial function and increase frataxin levels in a cellular model of Friedreich's ataxia

Khdour, O., Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P. & Hecht, S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

4 Scopus citations

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Mastroeni, D., Nolz, J., Khdour, O., Sekar, S., Delvaux, E., Cuyugan, L., Liang, W. S., Hecht, S. & Coleman, P., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

8 Scopus citations

Phenothiazine antioxidants increase mitochondrial biogenesis and frataxin levels in Friedreich's ataxia cells

Khdour, O., Bandyopadhyay, I., Visavadiya, N. P., Roy Chowdhury, S. & Hecht, S., Jan 1 2018, In : MedChemComm. 9, 9, p. 1491-1501 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rapid detection of a dengue virus RNA sequence with single molecule sensitivity using tandem toehold-mediated displacement reactions

Gao, M., Daniel, D., Zou, H., Jiang, S., Lin, S., Huang, C., Hecht, S. & Chen, S., Jan 1 2018, In : Chemical Communications. 54, 8, p. 968-971 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Study of the Lyase Activity of Human DNA Polymerase β Using Analogues of the Intermediate Schiff Base Complex

Daskalova, S. M., Bai, X. & Hecht, S., May 8 2018, In : Biochemistry. 57, 18, p. 2711-2722 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

DNA-affibody nanoparticles for inhibiting breast cancer cells overexpressing HER2

Zhang, Y., Jiang, S., Zhang, D., Bai, X., Hecht, S. & Chen, S., 2017, In : Chemical Communications. 53, 3, p. 573-576 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids

Bai, X., Talukder, P., Daskalova, S. M., Roy, B., Chen, S., Li, Z., Dedkova, L. & Hecht, S., Apr 5 2017, In : Journal of the American Chemical Society. 139, 13, p. 4611-4614 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB

Chen, S., Maini, R., Bai, X., Nangreave, R. C., Dedkova, L. & Hecht, S., Oct 11 2017, In : Journal of the American Chemical Society. 139, 40, p. 14098-14108 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Influence of substituent heteroatoms on the cytoprotective properties of pyrimidinol antioxidants

Chevalier, A., Khdour, O., Schmierer, M., Bandyopadhyay, I. & Hecht, S., Mar 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 5, p. 1703-1716 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A

Zhang, Y., Chevalier, A., Khdour, O., Soto, L. M. & Hecht, S., May 20 2017, (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

1 Scopus citations

Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction

Roy Chowdhury, S., Khdour, O., Bandyopadhyay, I. & Hecht, S., Oct 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5537-5547 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Prescreening of Nicotine Hapten Linkers in Vitro To Select Hapten-Conjugate Vaccine Candidates for Pharmacokinetic Evaluation in Vivo

Arutla, V., Leal, J., Liu, X., Sokalingam, S., Raleigh, M., Adaralegbe, A., Liu, L., Pentel, P. R., Hecht, S. & Chang, Y., May 8 2017, In : ACS Combinatorial Science. 19, 5, p. 286-298 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase β with Unnatural Lysine Analogues

Daskalova, S. M., Bhattacharya, C., Dedkova, L. & Hecht, S., Jan 24 2017, In : Biochemistry. 56, 3, p. 500-513 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA

Roy, B., Talukder, P., Kang, H. J., Tsuen, S. S., Alam, M. P., Hurley, L. H. & Hecht, S., Aug 31 2016, In : Journal of the American Chemical Society. 138, 34, p. 10950-10962 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting

Chevalier, A., Zhang, Y., Khdour, O., Kaye, J. B. & Hecht, S., Sep 21 2016, In : Journal of the American Chemical Society. 138, 37, p. 12009-12012 4 p.

Research output: Contribution to journalArticle

67 Scopus citations

Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

Mastroeni, D., Khdour, O., Delvaux, E., Nolz, J., Olsen, G., Berchtold, N., Cotman, C., Hecht, S. & Coleman, P., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

21 Scopus citations

Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability

Chevalier, A., Alam, M. P., Khdour, O., Schmierer, M., Arce, P. M., Cripe, C. D. & Hecht, S., Nov 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5206-5220 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Selective Functionalization of Antimycin A Through an N-Transacylation Reaction

Chevalier, A., Zhang, Y., Khdour, O. & Hecht, S., May 20 2016, In : Organic Letters. 18, 10, p. 2395-2398 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Synthesis and evaluation of a library of fluorescent dipeptidomimetic analogues as substrates for modified bacterial ribosomes

Chowdhury, S. R., Chauhan, P. S., Dedkova, L., Bai, X., Chen, S., Talukder, P. & Hecht, S., May 3 2016, In : Biochemistry. 55, 17, p. 2427-2440 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Synthesis of alanyl nucleobase amino acids and their incorporation into proteins

Talukder, P., Dedkova, L., Ellington, A. D., Yakovchuk, P., Lim, J., Anslyn, E. V. & Hecht, S., Sep 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 18, p. 4177-4187 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction

Talukder, P., Chen, S., Roy, B., Yakovchuk, P., Spiering, M. M., Alam, M. P., Madathil, M. M., Bhattacharya, C., Benkovic, S. J. & Hecht, S., Dec 29 2015, In : Biochemistry. 54, 51, p. 7457-7469 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase

Bernatchez, J. A., Paul, R., Tchesnokov, E. P., Ngure, M., Beilhartz, G. L., Berghuis, A. M., Lavoie, R., Li, L., Auger, A., Melnyk, R. A., Grobler, J. A., Miller, M. D., Hazuda, D. J., Hecht, S. & Götte, M., Jan 16 2015, In : Journal of Biological Chemistry. 290, 3, p. 1474-1484 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensors

Gerasimova, Y. V., Yakovchuk, P., Dedkova, L., Hecht, S. & Kolpashchikov, D. M., Oct 1 2015, In : RNA. 21, 10, p. 1834-1843 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Fluorescent CD4 probe for potential HIV-1 gp120 protein detection

Wang, Z., Talukder, P., Hecht, S. & Chen, S., Mar 15 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 6, p. 1182-1185 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
10 Scopus citations

Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids

Maini, R., Chowdhury, S. R., Dedkova, L., Roy, B., Daskalova, S. M., Paul, R., Chen, S. & Hecht, S., Jun 16 2015, In : Biochemistry. 54, 23, p. 3694-3706 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro

Maini, R., Dedkova, L., Paul, R., Madathil, M. M., Chowdhury, S. R., Chen, S. & Hecht, S., Sep 9 2015, In : Journal of the American Chemical Society. 137, 35, p. 11206-11209 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Structural features facilitating tumor cell targeting and internalization by bleomycin and its disaccharide

Yu, Z., Paul, R., Bhattacharya, C., Bozeman, T. C., Rishel, M. J. & Hecht, S., May 19 2015, In : Biochemistry. 54, 19, p. 3100-3109 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Synthesis of fluorescent dipeptidomimetics and their ribosomal incorporation into green fluorescent protein

Roy Chowdhury, S., Maini, R., Dedkova, L. & Hecht, S., May 8 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 21, p. 4715-4718 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

Tang, C., Paul, A., Alam, M. P., Roy, B., Wilson, W. D. & Hecht, S., Sep 4 2014, In : Journal of the American Chemical Society. 136, 39, p. 13715-13726 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases

Alam, M. P., Khdour, O., Arce, P. M., Chen, Y., Roy, B., Johnson, W. G., Dey, S. & Hecht, S., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4935-4947 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

DNA methylation reduces binding and cleavage by bleomycin

Roy, B., Tang, C., Alam, M. P. & Hecht, S., Sep 30 2014, In : Biochemistry. 53, 38, p. 6103-6112 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Efficient asymmetric synthesis of Tryptophan Analogues having useful Photophysical properties

Talukder, P., Chen, S., Arce, P. M. & Hecht, S., Mar 17 2014, In : Organic Letters. 16, 2, p. 556-559 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hairpin DNA sequences bound strongly by bleomycin exhibit enhanced double-strand cleavage

Roy, B. & Hecht, S., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4382-4393 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Modified bleomycin disaccharides exhibiting improved tumor cell targeting

Madathil, M. M., Bhattacharya, C., Yu, Z., Paul, R., Rishel, M. J. & Hecht, S., Nov 4 2014, In : Biochemistry. 53, 43, p. 6800-6810 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues

Yu, X., Talukder, P., Bhattacharya, C., Fahmi, N. E., Lines, J. A., Dedkova, L., LaBaer, J., Hecht, S. & Chen, S., Dec 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 24, p. 5699-5703 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

The carbamoylmannose moiety of bleomycin mediates selective tumor cell targeting

Bhattacharya, C., Yu, Z., Rishel, M. J. & Hecht, S., May 27 2014, In : Biochemistry. 53, 20, p. 3264-3266 3 p.

Research output: Contribution to journalArticle

58 Scopus citations

The disaccharide moiety of bleomycin facilitates uptake by cancer cells

Schroeder, B. R., Ghare, M. I., Bhattacharya, C., Paul, R., Yu, Z., Zaleski, P. A., Bozeman, T. C., Rishel, M. J. & Hecht, S., Oct 1 2014, In : Journal of the American Chemical Society. 136, 39, p. 13641-13656 16 p.

Research output: Contribution to journalArticle

87 Scopus citations

The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure

Kendrick, S., Kang, H. J., Alam, M. P., Madathil, M. M., Agrawal, P., Gokhale, V., Yang, D., Hecht, S. & Hurley, L. H., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4161-4171 11 p.

Research output: Contribution to journalArticle

123 Scopus citations

The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules

Kang, H. J., Kendrick, S., Hecht, S. & Hurley, L. H., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4172-4185 14 p.

Research output: Contribution to journalArticle

107 Scopus citations

Tryptophan-based fluorophores for studying protein conformational changes

Talukder, P., Chen, S., Liu, C. T., Baldwin, E. A., Benkovic, S. J. & Hecht, S., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5924-5934 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

An optimized pyrimidinol multifunctional radical quencher

Khdour, O., Arce, P. M., Roy, B. & Hecht, S., Aug 8 2013, In : ACS Medicinal Chemistry Letters. 4, 8, p. 724-729 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

A structurally simplified analogue of geldanamycin exhibits neuroprotective activity

Madathil, M. M., Khdour, O., Jaruvangsanti, J. & Hecht, S., Oct 10 2013, In : ACS Medicinal Chemistry Letters. 4, 10, p. 953-957 5 p.

Research output: Contribution to journalArticle

3 Scopus citations