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  • John Spence
2010

A coherent photofield electron source for fast diffractive and point-projection imaging

Spence, J., Vecchione, T. & Weierstall, U., Dec 14 2010, In : Philosophical Magazine. 90, 35-36, p. 4691-4702 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Beyond small-angle x-ray scattering: Exploiting angular correlations

Saldin, D. K., Poon, H. C., Shneerson, V. L., Howells, M., Chapman, H. N., Kirian, R., Schmidt, K. & Spence, J., May 7 2010, In : Physical Review B - Condensed Matter and Materials Physics. 81, 17, 174105.

Research output: Contribution to journalArticle

48 Scopus citations

Combined structure-factor phase measurement and theoretical calculations for mapping of chemical bonds in GaN

Jiang, B., Zuo, J. M., Holec, D., Humphreys, C. J., Spackman, M. & Spence, J., Jul 2 2010, In : Acta Crystallographica Section A: Foundations of Crystallography. 66, 4, p. 446-450 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Design of an electron microscope phase plate using a focused continuous-wave laser

Müller, H., Jin, J., Danev, R., Spence, J., Padmore, H. & Glaeser, R. M., Jul 12 2010, In : New Journal of Physics. 12, 073011.

Research output: Contribution to journalArticle

37 Scopus citations

Electronic ionization induced atom migration in spinel MgAl 2O4

Jiang, N. & Spence, J., Aug 1 2010, In : Journal of Nuclear Materials. 403, 1-3, p. 147-151 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Femtosecond protein nanocrystallography- Data analysis methods

Kirian, R., Wang, X., Weierstall, U., Schmidt, K., Spence, J., Hunter, M., Fromme, P., White, T., Chapman, H. N. & Holton, J., Mar 15 2010, In : Optics Express. 18, 6, p. 5713-5723 11 p.

Research output: Contribution to journalArticle

160 Scopus citations

High-Resolution Electron Microscopy

Spence, J., Jan 1 2010, Oxford University Press. 424 p.

Research output: Book/ReportBook

264 Scopus citations

Liquid capillary micro/nanojets in free-jet expansion

Gañán-Calvo, A. M., DePonte, D. P., Herrada, M. A., Spence, J., Weierstall, U. & Doak, R. B., Apr 9 2010, In : Small. 6, 7, p. 822-824 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

On the formation of Na nanoparticles in femtosecond-laser irradiated glasses

Jiang, N., Su, D., Qiu, J. & Spence, J., Apr 14 2010, In : Journal of Applied Physics. 107, 6, 064301.

Research output: Contribution to journalArticle

5 Scopus citations

On the measurement of thickness in nanoporous materials by EELS

Jiang, N., Su, D. & Spence, J., Dec 1 2010, In : Ultramicroscopy. 111, 1, p. 62-65 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
21 Scopus citations

Reconstruction of the electron density of molecules with single-axis alignment

Starodub, D., Spence, J. & Saldin, D. K., Nov 8 2010, Image Reconstruction from Incomplete Data VI. 78000O. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 7800).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Structure of a single particle from scattering by many particles randomly oriented about an axis: Toward structure solution without crystallization?

Saldin, D. K., Shneerson, V. L., Howells, M. R., Marchesini, S., Chapman, H. N., Bogan, M., Shapiro, D., Kirian, R., Weierstall, U., Schmidt, K. & Spence, J., Mar 31 2010, In : New Journal of Physics. 12, 035014.

Research output: Contribution to journalArticle

45 Scopus citations
2011

Automatic recovery of missing amplitudes and phases in tilt-limited electron crystallography of two-dimensional crystals

Gipson, B. R., Masiel, D. J., Browning, N. D., Spence, J., Mitsuoka, K. & Stahlberg, H., Jul 22 2011, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 84, 1, 011916.

Research output: Contribution to journalArticle

18 Scopus citations

Femtosecond nanocrystallography using X-ray lasers for membrane protein structure determination

Fromme, P. & Spence, J., Aug 1 2011, In : Current Opinion in Structural Biology. 21, 4, p. 509-516 8 p.

Research output: Contribution to journalReview article

57 Scopus citations

Femtosecond X-ray protein nanocrystallography

Chapman, H. N., Fromme, P., Barty, A., White, T. A., Kirian, R., Aquila, A., Hunter, M. S., Schulz, J., Deponte, D. P., Weierstall, U., Doak, R. B., Maia, F. R. N. C., Martin, A. V., Schlichting, I., Lomb, L., Coppola, N., Shoeman, R. L., Epp, S. W., Hartmann, R., Rolles, D. & 68 others, Rudenko, A., Foucar, L., Kimmel, N., Weidenspointner, G., Holl, P., Liang, M., Barthelmess, M., Caleman, C., Boutet, S., Bogan, M. J., Krzywinski, J., Bostedt, C., Bajt, S., Gumprecht, L., Rudek, B., Erk, B., Schmidt, C., Hömke, A., Reich, C., Pietschner, D., Ströder, L., Hauser, G., Gorke, H., Ullrich, J., Herrmann, S., Schaller, G., Schopper, F., Soltau, H., Kühnel, K. U., Messerschmidt, M., Bozek, J. D., Hau-Riege, S. P., Frank, M., Hampton, C. Y., Sierra, R. G., Starodub, D., Williams, G. J., Hajdu, J., Timneanu, N., Seibert, M. M., Andreasson, J., Rocker, A., Jönsson, O., Svenda, M., Stern, S., Nass, K., Andritschke, R., Schröter, C. D., Krasniqi, F., Bott, M., Schmidt, K., Wang, X., Grotjohann, I., Holton, J. M., Barends, T. R. M., Neutze, R., Marchesini, S., Fromme, R., Schorb, S., Rupp, D., Adolph, M., Gorkhover, T., Andersson, I., Hirsemann, H., Potdevin, G., Graafsma, H., Nilsson, B. & Spence, J., Feb 3 2011, In : Nature. 470, 7332, p. 73-78 6 p.

Research output: Contribution to journalArticle

1276 Scopus citations

In situ EELS study of dehydration of Al(OH)3 by electron beam irradiation

Jiang, N. & Spence, J., Jun 1 2011, In : Ultramicroscopy. 111, 7, p. 860-864 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

New directions in X-ray microscopy

Falcone, R., Jacobsen, C., Kirz, J., Marchesini, S., Shapiro, D. & Spence, J., Jul 1 2011, In : Contemporary Physics. 52, 4, p. 293-318 26 p.

Research output: Contribution to journalArticle

57 Scopus citations

New light on disordered ensembles: Ab initio structure determination of one particle from scattering fluctuations of many copies

Saldin, D. K., Poon, H. C., Bogan, M. J., Marchesini, S., Shapiro, D. A., Kirian, R., Weierstall, U. & Spence, J., Mar 14 2011, In : Physical Review Letters. 106, 11, 115501.

Research output: Contribution to journalArticle

59 Scopus citations

On the measurement of the Casimir torque

Chen, X. & Spence, J., Sep 1 2011, In : Physica Status Solidi (B) Basic Research. 248, 9, p. 2064-2071 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Phasing of coherent femtosecond X-ray diffraction from size-varying nanocrystals

Spence, J., Kirian, R., Wang, X., Weierstall, U., Schmidt, K., White, T., Barty, A., Chapman, H. N., Marchesini, S. & Holton, J., Feb 14 2011, In : Optics Express. 19, 4, p. 2866-2873 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser

Lomb, L., Barends, T. R. M., Kassemeyer, S., Aquila, A., Epp, S. W., Erk, B., Foucar, L., Hartmann, R., Rudek, B., Rolles, D., Rudenko, A., Shoeman, R. L., Andreasson, J., Bajt, S., Barthelmess, M., Barty, A., Bogan, M. J., Bostedt, C., Bozek, J. D., Caleman, C. & 45 others, Coffee, R., Coppola, N., Deponte, D. P., Doak, R. B., Ekeberg, T., Fleckenstein, H., Fromme, P., Gebhardt, M., Graafsma, H., Gumprecht, L., Hampton, C. Y., Hartmann, A., Hauser, G., Hirsemann, H., Holl, P., Holton, J. M., Hunter, M. S., Kabsch, W., Kimmel, N., Kirian, R., Liang, M., Maia, F. R. N. C., Meinhart, A., Marchesini, S., Martin, A. V., Nass, K., Reich, C., Schulz, J., Seibert, M. M., Sierra, R., Soltau, H., Spence, J., Steinbrener, J., Stellato, F., Stern, S., Timneanu, N., Wang, X., Weidenspointner, G., Weierstall, U., White, T. A., Wunderer, C., Chapman, H. N., Ullrich, J., Strüder, L. & Schlichting, I., Dec 20 2011, In : Physical Review B - Condensed Matter and Materials Physics. 84, 21, 214111.

Research output: Contribution to journalArticle

124 Scopus citations
46 Scopus citations

Simulations of radiation damage in biomolecular nanocrystals induced by femtosecond X-ray pulses

Caleman, C., Bergh, M., Scott, H. A., Spence, J., Chapman, H. N. & Timneanu, N., Sep 20 2011, In : Journal of Modern Optics. 58, 16, p. 1486-1497 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Single mimivirus particles intercepted and imaged with an X-ray laser

Seibert, M. M., Ekeberg, T., Maia, F. R. N. C., Svenda, M., Andreasson, J., Jönsson, O., Odić, D., Iwan, B., Rocker, A., Westphal, D., Hantke, M., Deponte, D. P., Barty, A., Schulz, J., Gumprecht, L., Coppola, N., Aquila, A., Liang, M., White, T. A., Martin, A. & 69 others, Caleman, C., Stern, S., Abergel, C., Seltzer, V., Claverie, J. M., Bostedt, C., Bozek, J. D., Boutet, S., Miahnahri, A. A., Messerschmidt, M., Krzywinski, J., Williams, G., Hodgson, K. O., Bogan, M. J., Hampton, C. Y., Sierra, R. G., Starodub, D., Andersson, I., Bajt, S., Barthelmess, M., Spence, J., Fromme, P., Weierstall, U., Kirian, R., Hunter, M., Doak, R. B., Marchesini, S., Hau-Riege, S. P., Frank, M., Shoeman, R. L., Lomb, L., Epp, S. W., Hartmann, R., Rolles, D., Rudenko, A., Schmidt, C., Foucar, L., Kimmel, N., Holl, P., Rudek, B., Erk, B., Hömke, A., Reich, C., Pietschner, D., Weidenspointner, G., Strüder, L., Hauser, G., Gorke, H., Ullrich, J., Schlichting, I., Herrmann, S., Schaller, G., Schopper, F., Soltau, H., Kühnel, K. U., Andritschke, R., Schröter, C. D., Krasniqi, F., Bott, M., Schorb, S., Rupp, D., Adolph, M., Gorkhover, T., Hirsemann, H., Potdevin, G., Graafsma, H., Nilsson, B., Chapman, H. N. & Hajdu, J., Feb 3 2011, In : Nature. 470, 7332, p. 78-82 5 p.

Research output: Contribution to journalArticle

627 Scopus citations

Structure-factor analysis of femtosecond microdiffraction patterns from protein nanocrystals

Kirian, R., White, T. A., Holton, J. M., Chapman, H. N., Fromme, P., Barty, A., Lomb, L., Aquila, A., Maia, F. R. N. C., Martin, A. V., Fromme, R., Wang, X., Hunter, M. S., Schmidt, K. & Spence, J., Mar 1 2011, In : Acta Crystallographica Section A: Foundations of Crystallography. 67, 2, p. 131-140 10 p.

Research output: Contribution to journalArticle

110 Scopus citations

Towards ETEM serial crystallography: Electron diffraction from liquid jets

Deponte, D. P., Mckeown, J. T., Weierstall, U., Doak, R. B. & Spence, J., Jun 1 2011, In : Ultramicroscopy. 111, 7, p. 824-827 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

X-ray diffraction from Membrane protein nanocrystals

Hunter, M. S., DePonte, D. P., Shapiro, D. A., Kirian, R., Wang, X., Starodub, D., Marchesini, S., Weierstall, U., Doak, R. B., Spence, J. & Fromme, P., Jan 5 2011, In : Biophysical journal. 100, 1, p. 198-206 9 p.

Research output: Contribution to journalArticle

46 Scopus citations
2013

Casimir torque between birefringent plates with metamaterials

Chen, X. & Spence, J., Sep 1 2013, In : Physica Status Solidi (A) Applications and Materials Science. 210, 9, p. 1925-1932 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Development of coherent scattering and diffractive imaging and the COSMIC facility at the Advanced Light Source

Shapiro, D., Roy, S., Celestre, R., Chao, W., Doering, D., Howells, M., Kevan, S., Kilcoyne, D., Kirz, J., Marchesini, S., Seu, K. A., Schirotzek, A., Spence, J., Tyliszczak, T., Warwick, T., Voronov, D. & Padmore, H. A., Jan 1 2013, In : Journal of Physics: Conference Series. 425, PART 19, 192011.

Research output: Contribution to journalConference article

6 Scopus citations

Lawrence Bragg, microdiffraction and X-ray lasers

Spence, J., Jan 1 2013, In : Acta Crystallographica Section A: Foundations of Crystallography. 69, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Natively inhibited trypanosoma brucei cathepsin B structure determined by using an x-ray laser

Redecke, L., Nass, K., DePonte, D. P., White, T. A., Rehders, D., Barty, A., Stellato, F., Liang, M., Barends, T. R. M., Boutet, S., Williams, G. J., Messerschmidt, M., Seibert, M. M., Aquila, A., Arnlund, D., Bajt, S., Barth, T. B., Bogan, M. J., Caleman, C., Chao, T. C. & 29 others, Doak, R. B., Fleckenstein, H., Frank, M., Fromme, R., Galli, L., Grotjohann, I., Hunter, M. S., Johansson, L. C., Kassemeyer, S., Katona, G., Kirian, R., Koopmann, R., Kupitz, C., Lomb, L., Martin, A. V., Mogk, S., Neutze, R., Shoeman, R. L., Steinbrener, J., Timneanu, N., Wang, D., Weierstall, U., Zatsepin, N., Spence, J., Fromme, P., Schlichting, I., Duszenko, M., Betzel, C. & Chapman, H. N., Jan 11 2013, In : Science. 339, 6116, p. 227-230 4 p.

Research output: Contribution to journalArticle

307 Scopus citations

Serial femtosecond crystallography of G protein-coupled receptors

Liu, W., Wacker, D., Gati, C., Han, G. W., James, D., Wang, D., Nelson, G., Weierstall, U., Katritch, V., Barty, A., Zatsepin, N., Li, D., Messerschmidt, M., Boutet, S., Williams, G. J., Koglin, J. E., Seibert, M. M., Wang, C., Shah, S. T. A., Basu, S. & 13 others, Fromme, R., Kupitz, C., Rendek, K. N., Grotjohann, I., Fromme, P., Kirian, R., Beyerlein, K. R., White, T. A., Chapman, H. N., Caffrey, M., Spence, J., Stevens, R. C. & Cherezov, V., Jan 1 2013, In : Science. 342, 6165, p. 1521-1524 4 p.

Research output: Contribution to journalArticle

302 Scopus citations

Structure of a photosynthetic reaction centre determined by serial femtosecond crystallography

Johansson, L. C., Arnlund, D., Katona, G., White, T. A., Barty, A., Deponte, D. P., Shoeman, R. L., Wickstrand, C., Sharma, A., Williams, G. J., Aquila, A., Bogan, M. J., Caleman, C., Davidsson, J., Doak, R. B., Frank, M., Fromme, R., Galli, L., Grotjohann, I., Hunter, M. S. & 25 others, Kassemeyer, S., Kirian, R., Kupitz, C., Liang, M., Lomb, L., Malmerberg, E., Martin, A. V., Messerschmidt, M., Nass, K., Redecke, L., Seibert, M. M., Sjöhamn, J., Steinbrener, J., Stellato, F., Wang, D., Wahlgren, W. Y., Weierstall, U., Westenhoff, S., Zatsepin, N., Boutet, S., Spence, J., Schlichting, I., Chapman, H. N., Fromme, P. & Neutze, R., Dec 19 2013, In : Nature communications. 4, 2911.

Research output: Contribution to journalArticle

67 Scopus citations

The extraction of single-particle diffraction patterns from a multiple-particle diffraction pattern

Martin, A. V., Morgan, A. J., Ekeberg, T., Loh, N. D., Maia, F. R. N. C., Wang, F., Spence, J. & Chapman, H. N., Jul 1 2013, In : Optics Express. 21, 13, p. 15102-15112 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Three-dimensional single-particle imaging using angular correlations from X-ray laser data

Liu, H., Poon, B. K., Saldin, D. K., Spence, J. & Zwart, P. H., Jul 1 2013, In : Acta Crystallographica Section A: Foundations of Crystallography. 69, 4, a69.

Research output: Contribution to journalArticle

33 Scopus citations

Valence electron energy-loss spectroscopy study of ZrSiO4 and ZrO2

Jiang, N. & Spence, J., Nov 1 2013, In : Ultramicroscopy. 134, p. 68-76 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

7 Å resolution in protein twodimensional-crystal X-ray diffraction at Linac Coherent Light Source

Pedrini, B., Tsai, C. J., Capitani, G., Padeste, C., Hunter, M. S., Zatsepin, N., Barty, A., Henry Benner, W., Boutet, S., Feld, G. K., Hau-Riege, S. P., Kirian, R., Kupitz, C., Messerschmitt, M., Ogren, J. I., Pardini, T., Segelke, B., Williams, G. J., Spence, J., Abela, R. & 5 others, Coleman, M., Evans, J. E., Schertler, G. F. X., Frank, M. & Li, X. D., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130500.

Research output: Contribution to journalArticle

29 Scopus citations

Ab-initio phasing using nanocrystal shape transforms with incomplete unit cells

Liu, H., Zatsepin, N. & Spence, J., Jan 1 2014, In : IUCrJ. 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Approaches to time-resolved diffraction using an XFEL

Spence, J., Dec 1 2014, In : Faraday Discussions. 171, p. 429-438 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Coherent convergent-beam time-resolved X-ray diffraction

Spence, J., Zatsepin, N. & Li, C., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130325.

Research output: Contribution to journalArticle

11 Scopus citations

Direct phasing in femtosecond nanocrystallography. I. Diffraction characteristics

Chen, J. P. J., Spence, J. & Millane, R. P., Mar 2014, In : Acta Crystallographica Section A: Foundations and Advances. 70, 2, p. 143-153 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Direct phasing in femtosecond nanocrystallography. II. Phase retrieval

Chen, J. P. J., Spence, J. & Millane, R. P., Mar 2014, In : Acta Crystallographica Section A: Foundations and Advances. 70, 2, p. 154-161 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Double-focusing mixing jet for XFEL study of chemical kinetics

Wang, D., Weierstall, U., Pollack, L. & Spence, J., Nov 1 2014, In : Journal of Synchrotron Radiation. 21, p. 1364-1366 3 p.

Research output: Contribution to journalArticle

47 Scopus citations

Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

Lee, H. H., Cherni, I., Yu, H., Fromme, R., Doran, J. D., Grotjohann, I., Mittman, M., Basu, S., Deb, A., Dörner, K., Aquila, A., Barty, A., Boutet, S., Chapman, H. N., Doak, R. B., Hunter, M. S., James, D., Kirian, R., Kupitz, C., Lawrence, R. M. & 17 others, Liu, H., Nass, K., Schlichting, I., Schmidt, K., Seibert, M. M., Shoeman, R. L., Spence, J., Stellato, F., Weierstall, U., Williams, G. J., Yoon, C., Wang, D., Zatsepin, N., Hogue, B., Matoba, N., Fromme, P. & Leket-Mor, T., Aug 29 2014, In : IUCrJ. 1, p. 305-317 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Femtosecond X-ray diffraction from two-dimensional protein crystals

Frank, M., Carlson, D. B., Hunter, M. S., Williams, G. J., Messerschmidt, M., Zatsepin, N., Barty, A., Benner, W. H., Chu, K., Graf, A. T., Hau-Riege, S. P., Kirian, R., Padeste, C., Pardini, T., Pedrini, B., Segelke, B., Seibert, M. M., Spence, J., Tsai, C. J., Lane, S. M. & 5 others, Li, X. D., Schertler, G., Boutet, S., Coleman, M. & Evans, J. E., Feb 28 2014, In : IUCrJ. 1, p. 95-100 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Instrumentation and methods: General discussion

Küpper, J., Williams, G., Chapman, H., Reid, K., Christensen, J., Wörner, H. J., Seddon, E., Dixit, G., Campbell, E., Underwood, J., Woerner, M., Spence, J., Van Thor, J., Wolf, M., Vendrell, O., De Ninno, G., Bressler, C. & Berrah, N., Dec 1 2014, In : Faraday Discussions. 171, p. 505-523 19 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

Weierstall, U., James, D., Wang, C., White, T. A., Wang, D., Liu, W., Spence, J., Bruce Doak, R., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N., Liu, H., Basu, S., Wacker, D., Won Han, G., Katritch, V., Boutet, S. & 17 others, Messerschmidt, M., Williams, G. J., Koglin, J. E., Marvin Seibert, M., Klinker, M., Gati, C., Shoeman, R. L., Barty, A., Chapman, H. N., Kirian, R., Beyerlein, K. R., Stevens, R. C., Li, D., Shah, S. T. A., Howe, N., Caffrey, M. & Cherezov, V., Feb 14 2014, In : Nature communications. 5, 3309.

Research output: Contribution to journalArticle

320 Scopus citations

Mapping the continuous reciprocal space intensity distribution of X-ray serial crystallography

Yefanov, O., Gati, C., Bourenkov, G., Kirian, R., White, T. A., Spence, J., Chapman, H. N. & Barty, A., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130333.

Research output: Contribution to journalArticle

22 Scopus citations