Find Scholarly Works

Search concepts
Selected Filters
2013
Antineoplastic Agents
Tumors
Carbohydrates
Bleomycin
Methotrexate
15 Citations (Scopus)

Characterization of Bleomycin-Mediated Cleavage of a Hairpin DNA Library

Segerman, Z. J., Roy, B. & Hecht, S., Aug 6 2013, In : Biochemistry. 52, 31, p. 5315-5327 13 p.

Research output: Contribution to journalArticle

Bleomycin
Gene Library
DNA
DNA Cleavage
DNA Damage
40 Citations (Scopus)

Detection of dihydrofolate reductase conformational change by fret using two fluorescent amino acids

Chen, S., Fahmi, N. E., Wang, L., Bhattacharya, C., Benkovic, S. J. & Hecht, S., Sep 4 2013, In : Journal of the American Chemical Society. 135, 35, p. 12924-12927 4 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Amino acids
Amino Acids
Fluorophores
Energy Transfer
15 Citations (Scopus)

Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection

Fash, D. M., Khdour, O., Sahdeo, S. J., Goldschmidt, R., Jaruvangsanti, J., Dey, S., Arce, P. M., Collin, V. C., Cortopassi, G. A. & Hecht, S., Apr 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 8, p. 2346-2354 9 p.

Research output: Contribution to journalArticle

coenzyme Q10
diethyl maleate
Cytoprotection
Electron Transport
Ubiquinone
15 Citations (Scopus)

Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases

Goldschmidt, R., Arce, P. M., Khdour, O., Collin, V. C., Dey, S., Jaruvangsanti, J., Fash, D. M. & Hecht, S., Feb 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 4, p. 969-978 10 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Mitochondrial Diseases
coenzyme Q10
Lymphocytes
Neurodegenerative Diseases

Erratum: Characterization of bleomycin-mediated cleavage of a hairpin DNA library (Biochemistry (2013) 52:31 (5313-5327) DOI:10.1021/bi400779r)

Segerman, Z. J., Roy, B. & Hecht, S., Sep 10 2013, In : Biochemistry. 52, 36, p. 6300 1 p.

Research output: Contribution to journalArticle

Biochemistry
Bleomycin
Gene Library
10 Citations (Scopus)

Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification

Chen, S., Fahmi, N. E., Bhattacharya, C., Wang, L., Jin, Y., Benkovic, S. J. & Hecht, S., Nov 26 2013, In : Biochemistry. 52, 47, p. 8580-8589 10 p.

Research output: Contribution to journalArticle

Phenylalanine
Derivatives
Proteins
Amino Acids
Tetrahydrofolate Dehydrogenase
14 Citations (Scopus)

Improving the affinity of SL0101 for RSK using structure-based design

Mrozowski, R. M., Vemula, R., Wu, B., Zhang, Q., Schroeder, B. R., Hilinski, M. K., Clark, D. E., Hecht, S., O'Doherty, G. A. & Lannigan, D. A., Feb 14 2013, In : ACS Medicinal Chemistry Letters. 4, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

Phosphotransferases
Rhamnose
Biological Products
Protein Kinases
Half-Life
40 Citations (Scopus)

Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center

Maini, R., Nguyen, D. T., Chen, S., Dedkova, L., Chowdhury, S. R., Alcala-Torano, R. & Hecht, S., Mar 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 5, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

Peptidyl Transferases
Tetrahydrofolate Dehydrogenase
Ribosomes
Amino Acids
Alanine
DNA Vaccines
Nanostructures
Street Drugs
Nicotine
Antibody Formation
Disaccharides
Tumors
Carbohydrates
Imaging techniques
Bleomycin
214 Citations (Scopus)

Selective tumor cell targeting by the disaccharide moiety of bleomycin

Yu, Z., Schmaltz, R. M., Bozeman, T. C., Paul, R., Rishel, M. J., Tsosie, K. S. & Hecht, S., 2013, In : Journal of the American Chemical Society. 135, 8, p. 2883-2886 4 p.

Research output: Contribution to journalArticle

Disaccharides
Bleomycin
Tumors
Cells
Neoplasms
2012
Friedreich Ataxia
Mitochondrial Diseases
Leigh Disease
Tocopherols
Antioxidants
17 Citations (Scopus)

Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection

Arce, P. M., Goldschmidt, R., Khdour, O., Madathil, M. M., Jaruvangsanti, J., Dey, S., Fash, D. M., Armstrong, J. S. & Hecht, S., Sep 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 17, p. 5188-5201 14 p.

Research output: Contribution to journalArticle

Cytoprotection
Antioxidants
Lymphocytes
Neuroprotective Agents
Electron Transport
14 Citations (Scopus)

Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA

Bozeman, T. C., Nanjunda, R., Tang, C., Liu, Y., Segerman, Z. J., Zaleski, P. A., Wilson, W. D. & Hecht, S., Oct 31 2012, In : Journal of the American Chemical Society. 134, 43, p. 17842-17845 4 p.

Research output: Contribution to journalArticle

DNA Cleavage
Bleomycin
DNA
Substrates
Binding sites
8 Citations (Scopus)

Simplified bicyclic pyridinol analogues protect mitochondrial function

Cai, X., Khdour, O., Jaruvangsanti, J. & Hecht, S., Jun 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 11, p. 3584-3595 12 p.

Research output: Contribution to journalArticle

Antioxidants
Tocopherols
Oxidative stress
Bioactivity
Benzene
coenzyme Q10
Mitochondrial Diseases
Antioxidants
MELAS Syndrome
Adenosine Triphosphate
2 Citations (Scopus)

Synthesis and biological activities of N-(3-Carboxylpropyl)-5-amino-2- hydroxy-3-tridecyl-1,4-benzoquinone and analogues

Madathil, M. M., Khdour, O., Jaruvangsanti, J. & Hecht, S., Dec 28 2012, In : Journal of Natural Products. 75, 12, p. 2209-2215 7 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Oxidative stress
Lymphocytes
Bioactivity
Biological Products
13 Citations (Scopus)

Synthesis and biological activities of topopyrones

Zaleski, P. A., Maini, R., Leiris, S. J., Elban, M. A. & Hecht, S., Apr 27 2012, In : Journal of Natural Products. 75, 4, p. 577-585 9 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Type I DNA Topoisomerase
Bioactivity
Pyrones
Halogens
7 Citations (Scopus)

Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives

Chen, S., Fahmi, N. E., Nangreave, R. C., Mehellou, Y. & Hecht, S., Apr 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 8, p. 2679-2689 11 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Fluorophores
Esterification
Transfer RNA
Cysteine
26 Citations (Scopus)

Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics

Chen, S., Wang, L., Fahmi, N. E., Benkovic, S. J. & Hecht, S., Nov 21 2012, In : Journal of the American Chemical Society. 134, 46, p. 18883-18885 3 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Pyrene
Proteins
Mental Competency
Enzymes
35 Citations (Scopus)

β-puromycin selection of modified ribosomes for in vitro incorporation of β-amino acids

Dedkova, L., Fahmi, N. E., Paul, R., Del Rosario, M., Zhang, L., Chen, S., Feder, G. & Hecht, S., Jan 10 2012, In : Biochemistry. 51, 1, p. 401-415 15 p.

Research output: Contribution to journalArticle

Puromycin
Ribosomes
Peptidyl Transferases
Amino Acids
Transfer RNA
2011
13 Citations (Scopus)

An acetate prodrug of a pyridinol-based vitamin e analogue

Khdour, O., Lu, J. & Hecht, S., Nov 2011, In : Pharmaceutical Research. 28, 11, p. 2896-2909 14 p.

Research output: Contribution to journalArticle

Prodrugs
Vitamins
Acetates
Mitochondria
Oxidative stress
2 Citations (Scopus)

A new strategy for the synthesis of bisaminoacylated tRNAs

Nangreave, R. C., Dedkova, L., Chen, S. & Hecht, S., Sep 16 2011, In : Organic Letters. 13, 18, p. 4906-4909 4 p.

Research output: Contribution to journalArticle

Transfer RNA
amino acids
protein synthesis
synthesis
condensation
23 Citations (Scopus)

A strategy for suppressing redox stress within mitochondria

Arce, P. M., Khdour, O., Goldschmidt, R., Armstrong, J. S. & Hecht, S., Aug 11 2011, In : ACS Medicinal Chemistry Letters. 2, 8, p. 608-613 6 p.

Research output: Contribution to journalArticle

Mitochondria
Oxidative stress
Oxidation-Reduction
Oxidative Stress
Friedreich Ataxia
4 Citations (Scopus)

Deglycobleomycin A6 analogues modified in the methylvalerate moiety

Cai, X., Zaleski, P. A., Cagir, A. & Hecht, S., Jun 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 12, p. 3831-3844 14 p.

Research output: Contribution to journalArticle

DNA Cleavage
Bleomycin
DNA
Valerates
Superhelical DNA

Foreword

Hecht, S., Jul 25 2011, In : Unknown Journal.

Research output: Contribution to journalArticle

coenzyme Q10
Mitochondrial Diseases
Antioxidants
MELAS Syndrome
Adenosine Triphosphate
10 Citations (Scopus)

One-pot regio- and stereoselective synthesis of α′-methoxy- γ-pyrones: Biological evaluation as mitochondrial respiratory complex inhibitors

Rosso, H., De Paolis, M., Collin, V. C., Dey, S., Hecht, S., Prandi, C., Richard, V. & Maddaluno, J., Nov 18 2011, In : Journal of Organic Chemistry. 76, 22, p. 9429-9437 9 p.

Research output: Contribution to journalArticle

Pyrones
Electron Transport Complex I
Density functional theory
Molecules
Experiments
11 Citations (Scopus)

P-thiophenylalanine-induced DNA cleavage and religation activity of a modified vaccinia topoisomerase IB

Chen, S., Zhang, Y. & Hecht, S., Nov 1 2011, In : Biochemistry. 50, 43, p. 9340-9351 12 p.

Research output: Contribution to journalArticle

Vaccinia
DNA Cleavage
DNA
Type I DNA Topoisomerase
Enzymes
3 Citations (Scopus)

Structural basis for the exceptional stability of bisaminoacylated nucleotides and transfer RNAs

Duca, M., Trindle, C. O. & Hecht, S., Jul 27 2011, In : Journal of the American Chemical Society. 133, 29, p. 11368-11377 10 p.

Research output: Contribution to journalArticle

Nucleotides
Transfer RNA
Adenine
Adenosine Monophosphate
Adenosine
2010
19 Citations (Scopus)

Characterization of bleomycin cleavage sites in strongly bound hairpin DNAs

Giroux, R. A. & Hecht, S., Dec 1 2010, In : Journal of the American Chemical Society. 132, 47, p. 16987-16996 10 p.

Research output: Contribution to journalArticle

Bleomycin
DNA
Alkalies
Degradation
DNA Cleavage
20 Citations (Scopus)

Concise synthesis of bicyclic pyridinol antioxidants

Lu, J., Cai, X. & Hecht, S., Nov 19 2010, In : Organic Letters. 12, 22, p. 5189-5191 3 p.

Research output: Contribution to journalArticle

antioxidants
Antioxidants
tocopherol
Lactams
acetals
13 Citations (Scopus)

Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant

Lu, J., Khdour, O., Armstrong, J. S. & Hecht, S., Nov 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 21, p. 7628-7638 11 p.

Research output: Contribution to journalArticle

Tocopherols
Antioxidants
Trifluoroacetic Acid
Mitochondrial Membranes
Cultured Cells
76 Citations (Scopus)

Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question

Armstrong, J. S., Khdour, O. & Hecht, S., Jul 2010, In : FASEB Journal. 24, 7, p. 2152-2163 12 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Oxidative stress
Pathology
Reactive Oxygen Species
Oxidative Stress
27 Citations (Scopus)

Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria

Duveau, D. Y., Arce, P. M., Schoenfeld, R. A., Raghav, N., Cortopassi, G. A. & Hecht, S., Sep 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 17, p. 6429-6441 13 p.

Research output: Contribution to journalArticle

Mitochondria
Oxygen Consumption
Oxygen
diethyl maleate
Electron Transport
13 Citations (Scopus)

Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

Leiris, S. J., Khdour, O., Segerman, Z. J., Tsosie, K. S., Chapuis, J. & Hecht, S., May 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 10, p. 3481-3493 13 p.

Research output: Contribution to journalArticle

NAD
Oxidoreductases
Verticillium
Pyrones
Electron Transport Complex I