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Friedreich Ataxia
Mitochondrial Diseases
Leigh Disease
Tocopherols
Antioxidants
13 Citations (Scopus)

An acetate prodrug of a pyridinol-based vitamin e analogue

Khdour, O., Lu, J. & Hecht, S., Nov 2011, In : Pharmaceutical Research. 28, 11, p. 2896-2909 14 p.

Research output: Contribution to journalArticle

Prodrugs
Vitamins
Acetates
Mitochondria
Oxidative stress
17 Citations (Scopus)

Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection

Arce, P. M., Goldschmidt, R., Khdour, O., Madathil, M. M., Jaruvangsanti, J., Dey, S., Fash, D. M., Armstrong, J. S. & Hecht, S., Sep 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 17, p. 5188-5201 14 p.

Research output: Contribution to journalArticle

Cytoprotection
Antioxidants
Lymphocytes
Neuroprotective Agents
Electron Transport
2 Citations (Scopus)

A new strategy for the synthesis of bisaminoacylated tRNAs

Nangreave, R. C., Dedkova, L., Chen, S. & Hecht, S., Sep 16 2011, In : Organic Letters. 13, 18, p. 4906-4909 4 p.

Research output: Contribution to journalArticle

Transfer RNA
amino acids
protein synthesis
synthesis
condensation
11 Citations (Scopus)

An optimized pyrimidinol multifunctional radical quencher

Khdour, O., Arce, P. M., Roy, B. & Hecht, S., Aug 8 2013, In : ACS Medicinal Chemistry Letters. 4, 8, p. 724-729 6 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
coenzyme Q10
Oxidative stress
Lymphocytes
Antioxidants
14 Citations (Scopus)

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

Tang, C., Paul, A., Alam, M. P., Roy, B., Wilson, W. D. & Hecht, S., Sep 4 2014, In : Journal of the American Chemical Society. 136, 39, p. 13715-13726 12 p.

Research output: Contribution to journalArticle

DNA sequences
Bleomycin
DNA
DNA Cleavage
Gene Library
23 Citations (Scopus)

A strategy for suppressing redox stress within mitochondria

Arce, P. M., Khdour, O., Goldschmidt, R., Armstrong, J. S. & Hecht, S., Aug 11 2011, In : ACS Medicinal Chemistry Letters. 2, 8, p. 608-613 6 p.

Research output: Contribution to journalArticle

Mitochondria
Oxidative stress
Oxidation-Reduction
Oxidative Stress
Friedreich Ataxia
3 Citations (Scopus)

A structurally simplified analogue of geldanamycin exhibits neuroprotective activity

Madathil, M. M., Khdour, O., Jaruvangsanti, J. & Hecht, S., Oct 10 2013, In : ACS Medicinal Chemistry Letters. 4, 10, p. 953-957 5 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Lymphocytes
Cytoprotection
Mitochondrial Membrane Potential
Cytotoxicity
Antineoplastic Agents
Tumors
Carbohydrates
Bleomycin
Methotrexate
19 Citations (Scopus)

Characterization of bleomycin cleavage sites in strongly bound hairpin DNAs

Giroux, R. A. & Hecht, S., Dec 1 2010, In : Journal of the American Chemical Society. 132, 47, p. 16987-16996 10 p.

Research output: Contribution to journalArticle

Bleomycin
DNA
Alkalies
Degradation
DNA Cleavage
15 Citations (Scopus)

Characterization of Bleomycin-Mediated Cleavage of a Hairpin DNA Library

Segerman, Z. J., Roy, B. & Hecht, S., Aug 6 2013, In : Biochemistry. 52, 31, p. 5315-5327 13 p.

Research output: Contribution to journalArticle

Bleomycin
Gene Library
DNA
DNA Cleavage
DNA Damage

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P., Hecht, S. & Khdour, O., Oct 1 2018, In : Data in Brief. 20, p. 1105-1114 10 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Methylene Blue
frataxin
20 Citations (Scopus)

Concise synthesis of bicyclic pyridinol antioxidants

Lu, J., Cai, X. & Hecht, S., Nov 19 2010, In : Organic Letters. 12, 22, p. 5189-5191 3 p.

Research output: Contribution to journalArticle

antioxidants
Antioxidants
tocopherol
Lactams
acetals
26 Citations (Scopus)

Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction

Talukder, P., Chen, S., Roy, B., Yakovchuk, P., Spiering, M. M., Alam, M. P., Madathil, M. M., Bhattacharya, C., Benkovic, S. J. & Hecht, S., Dec 29 2015, In : Biochemistry. 54, 51, p. 7457-7469 13 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
DNA Polymerase I
Heterogeneous-Nuclear Ribonucleoprotein L
Energy Transfer
Energy transfer
13 Citations (Scopus)

Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases

Alam, M. P., Khdour, O., Arce, P. M., Chen, Y., Roy, B., Johnson, W. G., Dey, S. & Hecht, S., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4935-4947 13 p.

Research output: Contribution to journalArticle

Mitochondrial Diseases
Neurodegenerative Diseases
Antioxidants
Mitochondrial Membrane Potential
Liver Microsomes
4 Citations (Scopus)

Deglycobleomycin A6 analogues modified in the methylvalerate moiety

Cai, X., Zaleski, P. A., Cagir, A. & Hecht, S., Jun 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 12, p. 3831-3844 14 p.

Research output: Contribution to journalArticle

DNA Cleavage
Bleomycin
DNA
Valerates
Superhelical DNA
9 Citations (Scopus)

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase

Bernatchez, J. A., Paul, R., Tchesnokov, E. P., Ngure, M., Beilhartz, G. L., Berghuis, A. M., Lavoie, R., Li, L., Auger, A., Melnyk, R. A., Grobler, J. A., Miller, M. D., Hazuda, D. J., Hecht, S. & Götte, M., Jan 16 2015, In : Journal of Biological Chemistry. 290, 3, p. 1474-1484 11 p.

Research output: Contribution to journalArticle

HIV-1
Foscarnet
Derivatives
RNA-Directed DNA Polymerase
Metal ions
13 Citations (Scopus)

Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant

Lu, J., Khdour, O., Armstrong, J. S. & Hecht, S., Nov 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 21, p. 7628-7638 11 p.

Research output: Contribution to journalArticle

Tocopherols
Antioxidants
Trifluoroacetic Acid
Mitochondrial Membranes
Cultured Cells
40 Citations (Scopus)

Detection of dihydrofolate reductase conformational change by fret using two fluorescent amino acids

Chen, S., Fahmi, N. E., Wang, L., Bhattacharya, C., Benkovic, S. J. & Hecht, S., Sep 4 2013, In : Journal of the American Chemical Society. 135, 35, p. 12924-12927 4 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Amino acids
Amino Acids
Fluorophores
Energy Transfer
11 Citations (Scopus)

DNA-affibody nanoparticles for inhibiting breast cancer cells overexpressing HER2

Zhang, Y., Jiang, S., Zhang, D., Bai, X., Hecht, S. & Chen, S., 2017, In : Chemical Communications. 53, 3, p. 573-576 4 p.

Research output: Contribution to journalArticle

DNA
Cells
Nanoparticles
Doxorubicin
Molecules
8 Citations (Scopus)

DNA methylation reduces binding and cleavage by bleomycin

Roy, B., Tang, C., Alam, M. P. & Hecht, S., Sep 30 2014, In : Biochemistry. 53, 38, p. 6103-6112 10 p.

Research output: Contribution to journalArticle

Bleomycin
DNA Methylation
DNA Cleavage
Methylation
DNA
76 Citations (Scopus)

Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question

Armstrong, J. S., Khdour, O. & Hecht, S., Jul 2010, In : FASEB Journal. 24, 7, p. 2152-2163 12 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Oxidative stress
Pathology
Reactive Oxygen Species
Oxidative Stress
14 Citations (Scopus)

Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA

Bozeman, T. C., Nanjunda, R., Tang, C., Liu, Y., Segerman, Z. J., Zaleski, P. A., Wilson, W. D. & Hecht, S., Oct 31 2012, In : Journal of the American Chemical Society. 134, 43, p. 17842-17845 4 p.

Research output: Contribution to journalArticle

DNA Cleavage
Bleomycin
DNA
Substrates
Binding sites
15 Citations (Scopus)

Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection

Fash, D. M., Khdour, O., Sahdeo, S. J., Goldschmidt, R., Jaruvangsanti, J., Dey, S., Arce, P. M., Collin, V. C., Cortopassi, G. A. & Hecht, S., Apr 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 8, p. 2346-2354 9 p.

Research output: Contribution to journalArticle

coenzyme Q10
diethyl maleate
Cytoprotection
Electron Transport
Ubiquinone
15 Citations (Scopus)

Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases

Goldschmidt, R., Arce, P. M., Khdour, O., Collin, V. C., Dey, S., Jaruvangsanti, J., Fash, D. M. & Hecht, S., Feb 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 4, p. 969-978 10 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Mitochondrial Diseases
coenzyme Q10
Lymphocytes
Neurodegenerative Diseases
15 Citations (Scopus)

Efficient asymmetric synthesis of Tryptophan Analogues having useful Photophysical properties

Talukder, P., Chen, S., Arce, P. M. & Hecht, S., 2014, In : Organic Letters. 16, 2, p. 556-559 4 p.

Research output: Contribution to journalArticle

tryptophan
Tryptophan
analogs
Tetrahydrofolate Dehydrogenase
probes
10 Citations (Scopus)

Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids

Bai, X., Talukder, P., Daskalova, S. M., Roy, B., Chen, S., Li, Z., Dedkova, L. & Hecht, S., Apr 5 2017, In : Journal of the American Chemical Society. 139, 13, p. 4611-4614 4 p.

Research output: Contribution to journalArticle

Nucleotide Motifs
Amino acids
DNA
Proteins
Amino Acids

Erratum: Characterization of bleomycin-mediated cleavage of a hairpin DNA library (Biochemistry (2013) 52:31 (5313-5327) DOI:10.1021/bi400779r)

Segerman, Z. J., Roy, B. & Hecht, S., Sep 10 2013, In : Biochemistry. 52, 36, p. 6300 1 p.

Research output: Contribution to journalArticle

Biochemistry
Bleomycin
Gene Library
2 Citations (Scopus)

Expanding the Scope of Protein Synthesis Using Modified Ribosomes

Dedkova, L. & Hecht, S., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6430-6447 18 p.

Research output: Contribution to journalArticle

Ribosomes
Peptides
Proteins
RNA
Amino acids
10 Citations (Scopus)

Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensors

Gerasimova, Y. V., Yakovchuk, P., Dedkova, L., Hecht, S. & Kolpashchikov, D. M., Oct 1 2015, In : RNA. 21, 10, p. 1834-1843 10 p.

Research output: Contribution to journalArticle

Catalytic DNA
Ribosomal RNA
Mutation
Cell Culture Techniques
Molecular Cloning
10 Citations (Scopus)

Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification

Chen, S., Fahmi, N. E., Bhattacharya, C., Wang, L., Jin, Y., Benkovic, S. J. & Hecht, S., Nov 26 2013, In : Biochemistry. 52, 47, p. 8580-8589 10 p.

Research output: Contribution to journalArticle

Phenylalanine
Derivatives
Proteins
Amino Acids
Tetrahydrofolate Dehydrogenase
2 Citations (Scopus)

Fluorescent CD4 probe for potential HIV-1 gp120 protein detection

Wang, Z., Talukder, P., Hecht, S. & Chen, S., Mar 15 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 6, p. 1182-1185 4 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
Tryptophan
HIV-1
Fluorescence
Evans Blue

Foreword

Hecht, S., Jul 25 2011, In : Unknown Journal.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Hairpin DNA sequences bound strongly by bleomycin exhibit enhanced double-strand cleavage

Roy, B. & Hecht, S., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4382-4393 12 p.

Research output: Contribution to journalArticle

DNA sequences
Bleomycin
DNA
Libraries
Base Pairing
14 Citations (Scopus)

Improving the affinity of SL0101 for RSK using structure-based design

Mrozowski, R. M., Vemula, R., Wu, B., Zhang, Q., Schroeder, B. R., Hilinski, M. K., Clark, D. E., Hecht, S., O'Doherty, G. A. & Lannigan, D. A., Feb 14 2013, In : ACS Medicinal Chemistry Letters. 4, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

Phosphotransferases
Rhamnose
Biological Products
Protein Kinases
Half-Life
4 Citations (Scopus)

In Cellulo Synthesis of Proteins Containing a Fluorescent Oxazole Amino Acid

Chen, S., Ji, X., Gao, M., Dedkova, L. & Hecht, S., Apr 10 2019, In : Journal of the American Chemical Society. 141, 14, p. 5597-5601 5 p.

Research output: Contribution to journalArticle

Oxazoles
Amino acids
Proteins
Amino Acids
Escherichia coli
6 Citations (Scopus)

Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB

Chen, S., Maini, R., Bai, X., Nangreave, R. C., Dedkova, L. & Hecht, S., Oct 11 2017, In : Journal of the American Chemical Society. 139, 40, p. 14098-14108 11 p.

Research output: Contribution to journalArticle

Tyrosine
Proteins
Puromycin
Phosphotyrosine
Ribosomes
40 Citations (Scopus)

Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center

Maini, R., Nguyen, D. T., Chen, S., Dedkova, L., Chowdhury, S. R., Alcala-Torano, R. & Hecht, S., Mar 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 5, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

Peptidyl Transferases
Tetrahydrofolate Dehydrogenase
Ribosomes
Amino Acids
Alanine
4 Citations (Scopus)

Influence of substituent heteroatoms on the cytoprotective properties of pyrimidinol antioxidants

Chevalier, A., Khdour, O., Schmierer, M., Bandyopadhyay, I. & Hecht, S., Mar 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 5, p. 1703-1716 14 p.

Research output: Contribution to journalArticle

Antioxidants
Mitochondrial Diseases
Liver Microsomes
Electron Transport
Bioactivity
1 Citation (Scopus)

Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A

Zhang, Y., Chevalier, A., Khdour, O., Soto, L. M. & Hecht, S., May 20 2017, (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

Antimycin A
Cell growth
Cells
Growth
Mitochondria
23 Citations (Scopus)

Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA

Roy, B., Talukder, P., Kang, H. J., Tsuen, S. S., Alam, M. P., Hurley, L. H. & Hecht, S., Aug 31 2016, In : Journal of the American Chemical Society. 138, 34, p. 10950-10962 13 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein L
Nucleotide Motifs
B-Cell Lymphoma
DNA
Genes
4 Citations (Scopus)

Lipophilic methylene blue analogues enhance mitochondrial function and increase frataxin levels in a cellular model of Friedreich's ataxia

Khdour, O., Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P. & Hecht, S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Friedreich Ataxia
Methylene Blue
Lymphocytes
Neurodegenerative Diseases
Aconitate Hydratase
2 Citations (Scopus)

Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction

Roy Chowdhury, S., Khdour, O., Bandyopadhyay, I. & Hecht, S., Oct 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5537-5547 11 p.

Research output: Contribution to journalArticle

Modulators
Friedreich Ataxia
Lymphocytes
Methylene Blue
Antioxidants
64 Citations (Scopus)

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting

Chevalier, A., Zhang, Y., Khdour, O., Kaye, J. B. & Hecht, S., Sep 21 2016, In : Journal of the American Chemical Society. 138, 37, p. 12009-12012 4 p.

Research output: Contribution to journalArticle

Nitroreductases
Mitochondria
Imaging techniques
Organelles
Trypanosomiasis
23 Citations (Scopus)

Modified bleomycin disaccharides exhibiting improved tumor cell targeting

Madathil, M. M., Bhattacharya, C., Yu, Z., Paul, R., Rishel, M. J. & Hecht, S., Nov 4 2014, In : Biochemistry. 53, 43, p. 6800-6810 11 p.

Research output: Contribution to journalArticle

Disaccharides
Bleomycin
Tumors
Cells
Neoplasms

Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction

Ji, X., Khdour, O. & Hecht, S., Jan 1 2019, In : Future Medicinal Chemistry. 11, 13, p. 1605-1624 20 p.

Research output: Contribution to journalReview article

Reactive Oxygen Species
Protective Agents
Mitochondrial Diseases
Ubiquinone
Tocopherols
coenzyme Q10
Mitochondrial Diseases
Antioxidants
MELAS Syndrome
Adenosine Triphosphate
10 Citations (Scopus)
Mitochondria
Amyloid
Epigenomics
Antioxidants
Maintenance
DNA Vaccines
Nanostructures
Street Drugs
Nicotine
Antibody Formation
21 Citations (Scopus)

Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

Mastroeni, D., Khdour, O., Delvaux, E., Nolz, J., Olsen, G., Berchtold, N., Cotman, C., Hecht, S. & Coleman, P., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Alzheimer Disease
Genes
Mitochondrial DNA
Disease Progression