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Author

  • Sidney Hecht
2010

Characterization of bleomycin cleavage sites in strongly bound hairpin DNAs

Giroux, R. A. & Hecht, S., Dec 1 2010, In : Journal of the American Chemical Society. 132, 47, p. 16987-16996 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Concise synthesis of bicyclic pyridinol antioxidants

Lu, J., Cai, X. & Hecht, S., Nov 19 2010, In : Organic Letters. 12, 22, p. 5189-5191 3 p.

Research output: Contribution to journalArticle

20 Scopus citations

Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant

Lu, J., Khdour, O., Armstrong, J. S. & Hecht, S., Nov 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 21, p. 7628-7638 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question

Armstrong, J. S., Khdour, O. & Hecht, S., Jul 1 2010, In : FASEB Journal. 24, 7, p. 2152-2163 12 p.

Research output: Contribution to journalReview article

76 Scopus citations

Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria

Duveau, D. Y., Arce, P. M., Schoenfeld, R. A., Raghav, N., Cortopassi, G. A. & Hecht, S., Sep 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 17, p. 6429-6441 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

Leiris, S. J., Khdour, O., Segerman, Z. J., Tsosie, K. S., Chapuis, J. & Hecht, S., May 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 10, p. 3481-3493 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

An acetate prodrug of a pyridinol-based vitamin e analogue

Khdour, O., Lu, J. & Hecht, S., Nov 1 2011, In : Pharmaceutical Research. 28, 11, p. 2896-2909 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

A new strategy for the synthesis of bisaminoacylated tRNAs

Nangreave, R. C., Dedkova, L., Chen, S. & Hecht, S., Sep 16 2011, In : Organic Letters. 13, 18, p. 4906-4909 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

A strategy for suppressing redox stress within mitochondria

Arce, P. M., Khdour, O., Goldschmidt, R., Armstrong, J. S. & Hecht, S., Aug 11 2011, In : ACS Medicinal Chemistry Letters. 2, 8, p. 608-613 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Deglycobleomycin A6 analogues modified in the methylvalerate moiety

Cai, X., Zaleski, P. A., Cagir, A. & Hecht, S., Jun 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 12, p. 3831-3844 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Foreword

Hecht, S., Jul 25 2011, In : Unknown Journal.

Research output: Contribution to journalArticle

One-pot regio- and stereoselective synthesis of α′-methoxy- γ-pyrones: Biological evaluation as mitochondrial respiratory complex inhibitors

Rosso, H., De Paolis, M., Collin, V. C., Dey, S., Hecht, S., Prandi, C., Richard, V. & Maddaluno, J., Nov 18 2011, In : Journal of Organic Chemistry. 76, 22, p. 9429-9437 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

P-thiophenylalanine-induced DNA cleavage and religation activity of a modified vaccinia topoisomerase IB

Chen, S., Zhang, Y. & Hecht, S., Nov 1 2011, In : Biochemistry. 50, 43, p. 9340-9351 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Structural basis for the exceptional stability of bisaminoacylated nucleotides and transfer RNAs

Duca, M., Trindle, C. O. & Hecht, S., Jul 27 2011, In : Journal of the American Chemical Society. 133, 29, p. 11368-11377 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012

Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection

Arce, P. M., Goldschmidt, R., Khdour, O., Madathil, M. M., Jaruvangsanti, J., Dey, S., Fash, D. M., Armstrong, J. S. & Hecht, S., Sep 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 17, p. 5188-5201 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA

Bozeman, T. C., Nanjunda, R., Tang, C., Liu, Y., Segerman, Z. J., Zaleski, P. A., Wilson, W. D. & Hecht, S., Oct 31 2012, In : Journal of the American Chemical Society. 134, 43, p. 17842-17845 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Simplified bicyclic pyridinol analogues protect mitochondrial function

Cai, X., Khdour, O., Jaruvangsanti, J. & Hecht, S., Jun 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 11, p. 3584-3595 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Synthesis and biological activities of N-(3-Carboxylpropyl)-5-amino-2- hydroxy-3-tridecyl-1,4-benzoquinone and analogues

Madathil, M. M., Khdour, O., Jaruvangsanti, J. & Hecht, S., Dec 28 2012, In : Journal of Natural Products. 75, 12, p. 2209-2215 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Synthesis and biological activities of topopyrones

Zaleski, P. A., Maini, R., Leiris, S. J., Elban, M. A. & Hecht, S., Apr 27 2012, In : Journal of Natural Products. 75, 4, p. 577-585 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives

Chen, S., Fahmi, N. E., Nangreave, R. C., Mehellou, Y. & Hecht, S., Apr 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 8, p. 2679-2689 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics

Chen, S., Wang, L., Fahmi, N. E., Benkovic, S. J. & Hecht, S., Nov 21 2012, In : Journal of the American Chemical Society. 134, 46, p. 18883-18885 3 p.

Research output: Contribution to journalArticle

27 Scopus citations

β-puromycin selection of modified ribosomes for in vitro incorporation of β-amino acids

Dedkova, L., Fahmi, N. E., Paul, R., Del Rosario, M., Zhang, L., Chen, S., Feder, G. & Hecht, S., Jan 10 2012, In : Biochemistry. 51, 1, p. 401-415 15 p.

Research output: Contribution to journalArticle

37 Scopus citations
2013

An optimized pyrimidinol multifunctional radical quencher

Khdour, O., Arce, P. M., Roy, B. & Hecht, S., Aug 8 2013, In : ACS Medicinal Chemistry Letters. 4, 8, p. 724-729 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

A structurally simplified analogue of geldanamycin exhibits neuroprotective activity

Madathil, M. M., Khdour, O., Jaruvangsanti, J. & Hecht, S., Oct 10 2013, In : ACS Medicinal Chemistry Letters. 4, 10, p. 953-957 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Characterization of Bleomycin-Mediated Cleavage of a Hairpin DNA Library

Segerman, Z. J., Roy, B. & Hecht, S., Aug 6 2013, In : Biochemistry. 52, 31, p. 5315-5327 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Detection of dihydrofolate reductase conformational change by fret using two fluorescent amino acids

Chen, S., Fahmi, N. E., Wang, L., Bhattacharya, C., Benkovic, S. J. & Hecht, S., Sep 4 2013, In : Journal of the American Chemical Society. 135, 35, p. 12924-12927 4 p.

Research output: Contribution to journalArticle

42 Scopus citations

Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection

Fash, D. M., Khdour, O., Sahdeo, S. J., Goldschmidt, R., Jaruvangsanti, J., Dey, S., Arce, P. M., Collin, V. C., Cortopassi, G. A. & Hecht, S., Apr 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 8, p. 2346-2354 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases

Goldschmidt, R., Arce, P. M., Khdour, O., Collin, V. C., Dey, S., Jaruvangsanti, J., Fash, D. M. & Hecht, S., Feb 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 4, p. 969-978 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Erratum: Characterization of bleomycin-mediated cleavage of a hairpin DNA library (Biochemistry (2013) 52:31 (5313-5327) DOI:10.1021/bi400779r)

Segerman, Z. J., Roy, B. & Hecht, S., Sep 10 2013, In : Biochemistry. 52, 36, 1 p.

Research output: Contribution to journalComment/debate

Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification

Chen, S., Fahmi, N. E., Bhattacharya, C., Wang, L., Jin, Y., Benkovic, S. J. & Hecht, S., Nov 26 2013, In : Biochemistry. 52, 47, p. 8580-8589 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Improving the affinity of SL0101 for RSK using structure-based design

Mrozowski, R. M., Vemula, R., Wu, B., Zhang, Q., Schroeder, B. R., Hilinski, M. K., Clark, D. E., Hecht, S., O'Doherty, G. A. & Lannigan, D. A., Feb 14 2013, In : ACS Medicinal Chemistry Letters. 4, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center

Maini, R., Nguyen, D. T., Chen, S., Dedkova, L., Chowdhury, S. R., Alcala-Torano, R. & Hecht, S., Mar 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 5, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Selective tumor cell targeting by the disaccharide moiety of bleomycin

Yu, Z., Schmaltz, R. M., Bozeman, T. C., Paul, R., Rishel, M. J., Tsosie, K. S. & Hecht, S., Mar 11 2013, In : Journal of the American Chemical Society. 135, 8, p. 2883-2886 4 p.

Research output: Contribution to journalArticle

216 Scopus citations
2014

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

Tang, C., Paul, A., Alam, M. P., Roy, B., Wilson, W. D. & Hecht, S., Sep 4 2014, In : Journal of the American Chemical Society. 136, 39, p. 13715-13726 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases

Alam, M. P., Khdour, O., Arce, P. M., Chen, Y., Roy, B., Johnson, W. G., Dey, S. & Hecht, S., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4935-4947 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

DNA methylation reduces binding and cleavage by bleomycin

Roy, B., Tang, C., Alam, M. P. & Hecht, S., Sep 30 2014, In : Biochemistry. 53, 38, p. 6103-6112 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Efficient asymmetric synthesis of Tryptophan Analogues having useful Photophysical properties

Talukder, P., Chen, S., Arce, P. M. & Hecht, S., Mar 17 2014, In : Organic Letters. 16, 2, p. 556-559 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hairpin DNA sequences bound strongly by bleomycin exhibit enhanced double-strand cleavage

Roy, B. & Hecht, S., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4382-4393 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Modified bleomycin disaccharides exhibiting improved tumor cell targeting

Madathil, M. M., Bhattacharya, C., Yu, Z., Paul, R., Rishel, M. J. & Hecht, S., Nov 4 2014, In : Biochemistry. 53, 43, p. 6800-6810 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues

Yu, X., Talukder, P., Bhattacharya, C., Fahmi, N. E., Lines, J. A., Dedkova, L., LaBaer, J., Hecht, S. & Chen, S., Dec 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 24, p. 5699-5703 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

The carbamoylmannose moiety of bleomycin mediates selective tumor cell targeting

Bhattacharya, C., Yu, Z., Rishel, M. J. & Hecht, S., May 27 2014, In : Biochemistry. 53, 20, p. 3264-3266 3 p.

Research output: Contribution to journalArticle

58 Scopus citations

The disaccharide moiety of bleomycin facilitates uptake by cancer cells

Schroeder, B. R., Ghare, M. I., Bhattacharya, C., Paul, R., Yu, Z., Zaleski, P. A., Bozeman, T. C., Rishel, M. J. & Hecht, S., Oct 1 2014, In : Journal of the American Chemical Society. 136, 39, p. 13641-13656 16 p.

Research output: Contribution to journalArticle

87 Scopus citations

The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure

Kendrick, S., Kang, H. J., Alam, M. P., Madathil, M. M., Agrawal, P., Gokhale, V., Yang, D., Hecht, S. & Hurley, L. H., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4161-4171 11 p.

Research output: Contribution to journalArticle

123 Scopus citations