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Author

  • Sidney Hecht
2011

Foreword

Hecht, S., Jul 25 2011, In : Unknown Journal.

Research output: Contribution to journalArticle

2013
2017

Prescreening of Nicotine Hapten Linkers in Vitro To Select Hapten-Conjugate Vaccine Candidates for Pharmacokinetic Evaluation in Vivo

Arutla, V., Leal, J., Liu, X., Sokalingam, S., Raleigh, M., Adaralegbe, A., Liu, L., Pentel, P. R., Hecht, S. & Chang, Y., May 8 2017, In : ACS Combinatorial Science. 19, 5, p. 286-298 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

The disaccharide moiety of bleomycin facilitates uptake by cancer cells

Schroeder, B. R., Ghare, M. I., Bhattacharya, C., Paul, R., Yu, Z., Zaleski, P. A., Bozeman, T. C., Rishel, M. J. & Hecht, S., Oct 1 2014, In : Journal of the American Chemical Society. 136, 39, p. 13641-13656 16 p.

Research output: Contribution to journalArticle

87 Scopus citations
2015

Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro

Maini, R., Dedkova, L., Paul, R., Madathil, M. M., Chowdhury, S. R., Chen, S. & Hecht, S., Sep 9 2015, In : Journal of the American Chemical Society. 137, 35, p. 11206-11209 4 p.

Research output: Contribution to journalArticle

26 Scopus citations
2013
2018

Phenothiazine antioxidants increase mitochondrial biogenesis and frataxin levels in Friedreich's ataxia cells

Khdour, O., Bandyopadhyay, I., Visavadiya, N. P., Roy Chowdhury, S. & Hecht, S., Jan 1 2018, In : MedChemComm. 9, 9, p. 1491-1501 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Expanding the Scope of Protein Synthesis Using Modified Ribosomes

Dedkova, L. & Hecht, S., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6430-6447 18 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensors

Gerasimova, Y. V., Yakovchuk, P., Dedkova, L., Hecht, S. & Kolpashchikov, D. M., Oct 1 2015, In : RNA. 21, 10, p. 1834-1843 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection

Fash, D. M., Khdour, O., Sahdeo, S. J., Goldschmidt, R., Jaruvangsanti, J., Dey, S., Arce, P. M., Collin, V. C., Cortopassi, G. A. & Hecht, S., Apr 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 8, p. 2346-2354 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

β-puromycin selection of modified ribosomes for in vitro incorporation of β-amino acids

Dedkova, L., Fahmi, N. E., Paul, R., Del Rosario, M., Zhang, L., Chen, S., Feder, G. & Hecht, S., Jan 10 2012, In : Biochemistry. 51, 1, p. 401-415 15 p.

Research output: Contribution to journalArticle

37 Scopus citations
2015

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase

Bernatchez, J. A., Paul, R., Tchesnokov, E. P., Ngure, M., Beilhartz, G. L., Berghuis, A. M., Lavoie, R., Li, L., Auger, A., Melnyk, R. A., Grobler, J. A., Miller, M. D., Hazuda, D. J., Hecht, S. & Götte, M., Jan 16 2015, In : Journal of Biological Chemistry. 290, 3, p. 1474-1484 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Fluorescent CD4 probe for potential HIV-1 gp120 protein detection

Wang, Z., Talukder, P., Hecht, S. & Chen, S., Mar 15 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 6, p. 1182-1185 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Improving the affinity of SL0101 for RSK using structure-based design

Mrozowski, R. M., Vemula, R., Wu, B., Zhang, Q., Schroeder, B. R., Hilinski, M. K., Clark, D. E., Hecht, S., O'Doherty, G. A. & Lannigan, D. A., Feb 14 2013, In : ACS Medicinal Chemistry Letters. 4, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
2019

Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction

Ji, X., Khdour, O. & Hecht, S., Jan 1 2019, In : Future Medicinal Chemistry. 11, 13, p. 1605-1624 20 p.

Research output: Contribution to journalReview article

2018

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Mastroeni, D., Nolz, J., Khdour, O., Sekar, S., Delvaux, E., Cuyugan, L., Liang, W. S., Hecht, S. & Coleman, P., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

Mastroeni, D., Khdour, O., Delvaux, E., Nolz, J., Olsen, G., Berchtold, N., Cotman, C., Hecht, S. & Coleman, P., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification

Chen, S., Fahmi, N. E., Bhattacharya, C., Wang, L., Jin, Y., Benkovic, S. J. & Hecht, S., Nov 26 2013, In : Biochemistry. 52, 47, p. 8580-8589 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015
2013

Erratum: Characterization of bleomycin-mediated cleavage of a hairpin DNA library (Biochemistry (2013) 52:31 (5313-5327) DOI:10.1021/bi400779r)

Segerman, Z. J., Roy, B. & Hecht, S., Sep 10 2013, In : Biochemistry. 52, 36, 1 p.

Research output: Contribution to journalComment/debate

2011

Deglycobleomycin A6 analogues modified in the methylvalerate moiety

Cai, X., Zaleski, P. A., Cagir, A. & Hecht, S., Jun 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 12, p. 3831-3844 14 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase β with Unnatural Lysine Analogues

Daskalova, S. M., Bhattacharya, C., Dedkova, L. & Hecht, S., Jan 24 2017, In : Biochemistry. 56, 3, p. 500-513 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Selective detection of dengue virus serotypes using tandem toehold-mediated displacement reactions

Gao, M., Waggoner, J. J., Hecht, S. M. & Chen, S., Jan 1 2019, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

2018

Study of the Lyase Activity of Human DNA Polymerase β Using Analogues of the Intermediate Schiff Base Complex

Daskalova, S. M., Bai, X. & Hecht, S., May 8 2018, In : Biochemistry. 57, 18, p. 2711-2722 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

One-pot regio- and stereoselective synthesis of α′-methoxy- γ-pyrones: Biological evaluation as mitochondrial respiratory complex inhibitors

Rosso, H., De Paolis, M., Collin, V. C., Dey, S., Hecht, S., Prandi, C., Richard, V. & Maddaluno, J., Nov 18 2011, In : Journal of Organic Chemistry. 76, 22, p. 9429-9437 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013
2018

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P., Hecht, S. & Khdour, O., Oct 1 2018, In : Data in Brief. 20, p. 1105-1114 10 p.

Research output: Contribution to journalArticle

2012

Synthesis and biological activities of topopyrones

Zaleski, P. A., Maini, R., Leiris, S. J., Elban, M. A. & Hecht, S., Apr 27 2012, In : Journal of Natural Products. 75, 4, p. 577-585 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Simplified bicyclic pyridinol analogues protect mitochondrial function

Cai, X., Khdour, O., Jaruvangsanti, J. & Hecht, S., Jun 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 11, p. 3584-3595 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2010

Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

Leiris, S. J., Khdour, O., Segerman, Z. J., Tsosie, K. S., Chapuis, J. & Hecht, S., May 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 10, p. 3481-3493 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction

Roy Chowdhury, S., Khdour, O., Bandyopadhyay, I. & Hecht, S., Oct 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5537-5547 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Lipophilic methylene blue analogues enhance mitochondrial function and increase frataxin levels in a cellular model of Friedreich's ataxia

Khdour, O., Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P. & Hecht, S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability

Chevalier, A., Alam, M. P., Khdour, O., Schmierer, M., Arce, P. M., Cripe, C. D. & Hecht, S., Nov 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5206-5220 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA

Roy, B., Talukder, P., Kang, H. J., Tsuen, S. S., Alam, M. P., Hurley, L. H. & Hecht, S., Aug 31 2016, In : Journal of the American Chemical Society. 138, 34, p. 10950-10962 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
2011

An acetate prodrug of a pyridinol-based vitamin e analogue

Khdour, O., Lu, J. & Hecht, S., Nov 1 2011, In : Pharmaceutical Research. 28, 11, p. 2896-2909 14 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012
2011
2010

Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria

Duveau, D. Y., Arce, P. M., Schoenfeld, R. A., Raghav, N., Cortopassi, G. A. & Hecht, S., Sep 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 17, p. 6429-6441 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question

Armstrong, J. S., Khdour, O. & Hecht, S., Jul 1 2010, In : FASEB Journal. 24, 7, p. 2152-2163 12 p.

Research output: Contribution to journalReview article

76 Scopus citations
2012

Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics

Chen, S., Wang, L., Fahmi, N. E., Benkovic, S. J. & Hecht, S., Nov 21 2012, In : Journal of the American Chemical Society. 134, 46, p. 18883-18885 3 p.

Research output: Contribution to journalArticle

27 Scopus citations
2013

Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center

Maini, R., Nguyen, D. T., Chen, S., Dedkova, L., Chowdhury, S. R., Alcala-Torano, R. & Hecht, S., Mar 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 5, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

40 Scopus citations
2012

Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA

Bozeman, T. C., Nanjunda, R., Tang, C., Liu, Y., Segerman, Z. J., Zaleski, P. A., Wilson, W. D. & Hecht, S., Oct 31 2012, In : Journal of the American Chemical Society. 134, 43, p. 17842-17845 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

An optimized pyrimidinol multifunctional radical quencher

Khdour, O., Arce, P. M., Roy, B. & Hecht, S., Aug 8 2013, In : ACS Medicinal Chemistry Letters. 4, 8, p. 724-729 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2010

Characterization of bleomycin cleavage sites in strongly bound hairpin DNAs

Giroux, R. A. & Hecht, S., Dec 1 2010, In : Journal of the American Chemical Society. 132, 47, p. 16987-16996 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2016

Synthesis of alanyl nucleobase amino acids and their incorporation into proteins

Talukder, P., Dedkova, L., Ellington, A. D., Yakovchuk, P., Lim, J., Anslyn, E. V. & Hecht, S., Sep 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 18, p. 4177-4187 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2013

Characterization of Bleomycin-Mediated Cleavage of a Hairpin DNA Library

Segerman, Z. J., Roy, B. & Hecht, S., Aug 6 2013, In : Biochemistry. 52, 31, p. 5315-5327 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2011

A new strategy for the synthesis of bisaminoacylated tRNAs

Nangreave, R. C., Dedkova, L., Chen, S. & Hecht, S., Sep 16 2011, In : Organic Letters. 13, 18, p. 4906-4909 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

Tang, C., Paul, A., Alam, M. P., Roy, B., Wilson, W. D. & Hecht, S., Sep 4 2014, In : Journal of the American Chemical Society. 136, 39, p. 13715-13726 12 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Synthesis of fluorescent dipeptidomimetics and their ribosomal incorporation into green fluorescent protein

Roy Chowdhury, S., Maini, R., Dedkova, L. & Hecht, S., May 8 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 21, p. 4715-4718 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Tryptophan-based fluorophores for studying protein conformational changes

Talukder, P., Chen, S., Liu, C. T., Baldwin, E. A., Benkovic, S. J. & Hecht, S., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5924-5934 11 p.

Research output: Contribution to journalArticle

15 Scopus citations