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2019

Expanding the Scope of Protein Synthesis Using Modified Ribosomes

Dedkova, L. & Hecht, S., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6430-6447 18 p.

Research output: Contribution to journalArticle

Ribosomes
Peptides
Proteins
RNA
Amino acids
2 Citations (Scopus)

In Cellulo Synthesis of Proteins Containing a Fluorescent Oxazole Amino Acid

Chen, S., Ji, X., Gao, M., Dedkova, L. & Hecht, S., Apr 10 2019, In : Journal of the American Chemical Society. 141, 14, p. 5597-5601 5 p.

Research output: Contribution to journalArticle

Oxazoles
Amino acids
Proteins
Amino Acids
Escherichia coli
2018

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P., Hecht, S. & Khdour, O., Oct 1 2018, In : Data in Brief. 20, p. 1105-1114 10 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Methylene Blue
frataxin
3 Citations (Scopus)

Lipophilic methylene blue analogues enhance mitochondrial function and increase frataxin levels in a cellular model of Friedreich's ataxia

Khdour, O., Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P. & Hecht, S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Friedreich Ataxia
Methylene Blue
Lymphocytes
Neurodegenerative Diseases
Aconitate Hydratase
5 Citations (Scopus)

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Mastroeni, D., Nolz, J., Khdour, O., Sekar, S., Delvaux, E., Cuyugan, L., Liang, W. S., Hecht, S. & Coleman, P., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

coenzyme Q10
Amyloid
Neuroglia
Neurons
Alzheimer Disease
1 Citation (Scopus)

Phenothiazine antioxidants increase mitochondrial biogenesis and frataxin levels in Friedreich's ataxia cells

Khdour, O., Bandyopadhyay, I., Visavadiya, N. P., Roy Chowdhury, S. & Hecht, S., Jan 1 2018, In : MedChemComm. 9, 9, p. 1491-1501 11 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Organelle Biogenesis
Antioxidants
Methylene Blue
Substitution reactions
2 Citations (Scopus)

Rapid detection of a dengue virus RNA sequence with single molecule sensitivity using tandem toehold-mediated displacement reactions

Gao, M., Daniel, D., Zou, H., Jiang, S., Lin, S., Huang, C., Hecht, S. & Chen, S., Jan 1 2018, In : Chemical Communications. 54, 8, p. 968-971 4 p.

Research output: Contribution to journalArticle

RNA
Viruses
DNA
Molecules
Amplification
2 Citations (Scopus)

Study of the Lyase Activity of Human DNA Polymerase β Using Analogues of the Intermediate Schiff Base Complex

Daskalova, S. M., Bai, X. & Hecht, S., May 8 2018, In : Biochemistry. 57, 18, p. 2711-2722 12 p.

Research output: Contribution to journalArticle

Lyases
Schiff Bases
DNA-Directed DNA Polymerase
Human Activities
Deoxyribose
2017
9 Citations (Scopus)

DNA-affibody nanoparticles for inhibiting breast cancer cells overexpressing HER2

Zhang, Y., Jiang, S., Zhang, D., Bai, X., Hecht, S. & Chen, S., 2017, In : Chemical Communications. 53, 3, p. 573-576 4 p.

Research output: Contribution to journalArticle

DNA
Cells
Nanoparticles
Doxorubicin
Molecules
9 Citations (Scopus)

Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids

Bai, X., Talukder, P., Daskalova, S. M., Roy, B., Chen, S., Li, Z., Dedkova, L. & Hecht, S., Apr 5 2017, In : Journal of the American Chemical Society. 139, 13, p. 4611-4614 4 p.

Research output: Contribution to journalArticle

Nucleotide Motifs
Amino acids
DNA
Proteins
Amino Acids
5 Citations (Scopus)

Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB

Chen, S., Maini, R., Bai, X., Nangreave, R. C., Dedkova, L. & Hecht, S., Oct 11 2017, In : Journal of the American Chemical Society. 139, 40, p. 14098-14108 11 p.

Research output: Contribution to journalArticle

Tyrosine
Proteins
Puromycin
Phosphotyrosine
Ribosomes
3 Citations (Scopus)

Influence of substituent heteroatoms on the cytoprotective properties of pyrimidinol antioxidants

Chevalier, A., Khdour, O., Schmierer, M., Bandyopadhyay, I. & Hecht, S., Mar 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 5, p. 1703-1716 14 p.

Research output: Contribution to journalArticle

Antioxidants
Mitochondrial Diseases
Liver Microsomes
Electron Transport
Bioactivity

Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A

Zhang, Y., Chevalier, A., Khdour, O., Soto, L. M. & Hecht, S., May 20 2017, (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

Antimycin A
Cell growth
Cells
Growth
Mitochondria
2 Citations (Scopus)

Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction

Roy Chowdhury, S., Khdour, O., Bandyopadhyay, I. & Hecht, S., Oct 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5537-5547 11 p.

Research output: Contribution to journalArticle

Modulators
Friedreich Ataxia
Lymphocytes
Methylene Blue
Antioxidants
1 Citation (Scopus)

Prescreening of Nicotine Hapten Linkers in Vitro To Select Hapten-Conjugate Vaccine Candidates for Pharmacokinetic Evaluation in Vivo

Arutla, V., Leal, J., Liu, X., Sokalingam, S., Raleigh, M., Adaralegbe, A., Liu, L., Pentel, P. R., Hecht, S. & Chang, Y., May 8 2017, In : ACS Combinatorial Science. 19, 5, p. 286-298 13 p.

Research output: Contribution to journalArticle

Conjugate Vaccines
Pharmacokinetics
Haptens
Nicotine
Carrier Proteins
2 Citations (Scopus)

Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase β with Unnatural Lysine Analogues

Daskalova, S. M., Bhattacharya, C., Dedkova, L. & Hecht, S., Jan 24 2017, In : Biochemistry. 56, 3, p. 500-513 14 p.

Research output: Contribution to journalArticle

Nucleophiles
Lyases
Schiff Bases
DNA-Directed DNA Polymerase
Lysine
2016
22 Citations (Scopus)

Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA

Roy, B., Talukder, P., Kang, H. J., Tsuen, S. S., Alam, M. P., Hurley, L. H. & Hecht, S., Aug 31 2016, In : Journal of the American Chemical Society. 138, 34, p. 10950-10962 13 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein L
Nucleotide Motifs
B-Cell Lymphoma
DNA
Genes
52 Citations (Scopus)

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting

Chevalier, A., Zhang, Y., Khdour, O., Kaye, J. B. & Hecht, S., Sep 21 2016, In : Journal of the American Chemical Society. 138, 37, p. 12009-12012 4 p.

Research output: Contribution to journalArticle

Nitroreductases
Mitochondria
Imaging techniques
Organelles
Trypanosomiasis
19 Citations (Scopus)

Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

Mastroeni, D., Khdour, O., Delvaux, E., Nolz, J., Olsen, G., Berchtold, N., Cotman, C., Hecht, S. & Coleman, P., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Alzheimer Disease
Genes
Mitochondrial DNA
Disease Progression
7 Citations (Scopus)

Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability

Chevalier, A., Alam, M. P., Khdour, O., Schmierer, M., Arce, P. M., Cripe, C. D. & Hecht, S., Nov 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5206-5220 15 p.

Research output: Contribution to journalArticle

Protective Agents
Antioxidants
Adenosine Triphosphate
Mitochondrial Diseases
Mitochondrial Membrane Potential
5 Citations (Scopus)

Selective Functionalization of Antimycin A Through an N-Transacylation Reaction

Chevalier, A., Zhang, Y., Khdour, O. & Hecht, S., May 20 2016, In : Organic Letters. 18, 10, p. 2395-2398 4 p.

Research output: Contribution to journalArticle

Antimycin A
Derivatives
Acylation
lungs
Salicylates
6 Citations (Scopus)

Synthesis and evaluation of a library of fluorescent dipeptidomimetic analogues as substrates for modified bacterial ribosomes

Chowdhury, S. R., Chauhan, P. S., Dedkova, L., Bai, X., Chen, S., Talukder, P. & Hecht, S., May 3 2016, In : Biochemistry. 55, 17, p. 2427-2440 14 p.

Research output: Contribution to journalArticle

Ribosomes
Fluorophores
Libraries
Green Fluorescent Proteins
Oxazoles
2 Citations (Scopus)

Synthesis of alanyl nucleobase amino acids and their incorporation into proteins

Talukder, P., Dedkova, L., Ellington, A. D., Yakovchuk, P., Lim, J., Anslyn, E. V. & Hecht, S., Sep 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 18, p. 4177-4187 11 p.

Research output: Contribution to journalArticle

Amino Acids
Nucleic Acids
DNA Polymerase I
Proteins
Tetrahydrofolate Dehydrogenase
2015
24 Citations (Scopus)

Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction

Talukder, P., Chen, S., Roy, B., Yakovchuk, P., Spiering, M. M., Alam, M. P., Madathil, M. M., Bhattacharya, C., Benkovic, S. J. & Hecht, S., Dec 29 2015, In : Biochemistry. 54, 51, p. 7457-7469 13 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
DNA Polymerase I
Heterogeneous-Nuclear Ribonucleoprotein L
Energy Transfer
Energy transfer
8 Citations (Scopus)

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase

Bernatchez, J. A., Paul, R., Tchesnokov, E. P., Ngure, M., Beilhartz, G. L., Berghuis, A. M., Lavoie, R., Li, L., Auger, A., Melnyk, R. A., Grobler, J. A., Miller, M. D., Hazuda, D. J., Hecht, S. & Götte, M., Jan 16 2015, In : Journal of Biological Chemistry. 290, 3, p. 1474-1484 11 p.

Research output: Contribution to journalArticle

HIV-1
Foscarnet
Derivatives
RNA-Directed DNA Polymerase
Metal ions
10 Citations (Scopus)

Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensors

Gerasimova, Y. V., Yakovchuk, P., Dedkova, L., Hecht, S. & Kolpashchikov, D. M., Oct 1 2015, In : RNA. 21, 10, p. 1834-1843 10 p.

Research output: Contribution to journalArticle

Catalytic DNA
Ribosomal RNA
Mutation
Cell Culture Techniques
Molecular Cloning
2 Citations (Scopus)

Fluorescent CD4 probe for potential HIV-1 gp120 protein detection

Wang, Z., Talukder, P., Hecht, S. & Chen, S., Mar 15 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 6, p. 1182-1185 4 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
Tryptophan
HIV-1
Fluorescence
Evans Blue
9 Citations (Scopus)
Mitochondria
Amyloid
Epigenomics
Antioxidants
Maintenance
24 Citations (Scopus)

Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids

Maini, R., Chowdhury, S. R., Dedkova, L., Roy, B., Daskalova, S. M., Paul, R., Chen, S. & Hecht, S., Jun 16 2015, In : Biochemistry. 54, 23, p. 3694-3706 13 p.

Research output: Contribution to journalArticle

Puromycin
Ribosomes
Alanine
Tetrahydrofolate Dehydrogenase
Amino Acids
Haptens
Nicotine
Vaccines
Directories
Tobacco Use Disorder
22 Citations (Scopus)

Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro

Maini, R., Dedkova, L., Paul, R., Madathil, M. M., Chowdhury, S. R., Chen, S. & Hecht, S., Sep 9 2015, In : Journal of the American Chemical Society. 137, 35, p. 11206-11209 4 p.

Research output: Contribution to journalArticle

Dipeptides
Ribosomes
Proteins
Puromycin
Clone Cells
34 Citations (Scopus)

Structural features facilitating tumor cell targeting and internalization by bleomycin and its disaccharide

Yu, Z., Paul, R., Bhattacharya, C., Bozeman, T. C., Rishel, M. J. & Hecht, S., May 19 2015, In : Biochemistry. 54, 19, p. 3100-3109 10 p.

Research output: Contribution to journalArticle

Disaccharides
Bleomycin
Tumors
Cells
Neoplasms
9 Citations (Scopus)

Synthesis of fluorescent dipeptidomimetics and their ribosomal incorporation into green fluorescent protein

Roy Chowdhury, S., Maini, R., Dedkova, L. & Hecht, S., May 8 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 21, p. 4715-4718 4 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Oxazoles
Thiazoles
Fluorophores
2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide
2014
14 Citations (Scopus)

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

Tang, C., Paul, A., Alam, M. P., Roy, B., Wilson, W. D. & Hecht, S., Sep 4 2014, In : Journal of the American Chemical Society. 136, 39, p. 13715-13726 12 p.

Research output: Contribution to journalArticle

DNA sequences
Bleomycin
DNA
DNA Cleavage
Gene Library
12 Citations (Scopus)

Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases

Alam, M. P., Khdour, O., Arce, P. M., Chen, Y., Roy, B., Johnson, W. G., Dey, S. & Hecht, S., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4935-4947 13 p.

Research output: Contribution to journalArticle

Mitochondrial Diseases
Neurodegenerative Diseases
Antioxidants
Mitochondrial Membrane Potential
Liver Microsomes
8 Citations (Scopus)

DNA methylation reduces binding and cleavage by bleomycin

Roy, B., Tang, C., Alam, M. P. & Hecht, S., Sep 30 2014, In : Biochemistry. 53, 38, p. 6103-6112 10 p.

Research output: Contribution to journalArticle

Bleomycin
DNA Methylation
DNA Cleavage
Methylation
DNA
15 Citations (Scopus)

Efficient asymmetric synthesis of Tryptophan Analogues having useful Photophysical properties

Talukder, P., Chen, S., Arce, P. M. & Hecht, S., 2014, In : Organic Letters. 16, 2, p. 556-559 4 p.

Research output: Contribution to journalArticle

tryptophan
Tryptophan
analogs
Tetrahydrofolate Dehydrogenase
probes
17 Citations (Scopus)

Hairpin DNA sequences bound strongly by bleomycin exhibit enhanced double-strand cleavage

Roy, B. & Hecht, S., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4382-4393 12 p.

Research output: Contribution to journalArticle

DNA sequences
Bleomycin
DNA
Libraries
Base Pairing
23 Citations (Scopus)

Modified bleomycin disaccharides exhibiting improved tumor cell targeting

Madathil, M. M., Bhattacharya, C., Yu, Z., Paul, R., Rishel, M. J. & Hecht, S., Nov 4 2014, In : Biochemistry. 53, 43, p. 6800-6810 11 p.

Research output: Contribution to journalArticle

Disaccharides
Bleomycin
Tumors
Cells
Neoplasms
5 Citations (Scopus)

Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues

Yu, X., Talukder, P., Bhattacharya, C., Fahmi, N. E., Lines, J. A., Dedkova, L., LaBaer, J., Hecht, S. & Chen, S., Dec 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 24, p. 5699-5703 5 p.

Research output: Contribution to journalArticle

Phenylalanine
HIV-1
Glycoproteins
HIV
Conformations
Dipeptides
Proteins
Peptides
Peptidomimetics
Chemical activation
57 Citations (Scopus)

The carbamoylmannose moiety of bleomycin mediates selective tumor cell targeting

Bhattacharya, C., Yu, Z., Rishel, M. J. & Hecht, S., May 27 2014, In : Biochemistry. 53, 20, p. 3264-3266 3 p.

Research output: Contribution to journalArticle

Bleomycin
Tumors
Cells
Neoplasms
Coloring Agents
83 Citations (Scopus)

The disaccharide moiety of bleomycin facilitates uptake by cancer cells

Schroeder, B. R., Ghare, M. I., Bhattacharya, C., Paul, R., Yu, Z., Zaleski, P. A., Bozeman, T. C., Rishel, M. J. & Hecht, S., Oct 1 2014, In : Journal of the American Chemical Society. 136, 39, p. 13641-13656 16 p.

Research output: Contribution to journalArticle

Disaccharides
Bleomycin
Cells
Tumors
DNA
113 Citations (Scopus)

The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure

Kendrick, S., Kang, H. J., Alam, M. P., Madathil, M. M., Agrawal, P., Gokhale, V., Yang, D., Hecht, S. & Hurley, L. H., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4161-4171 11 p.

Research output: Contribution to journalArticle

Gene expression
DNA
Modulation
Gene Expression
Stabilization
98 Citations (Scopus)

The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules

Kang, H. J., Kendrick, S., Hecht, S. & Hurley, L. H., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4172-4185 14 p.

Research output: Contribution to journalArticle

Switch Genes
Heterogeneous-Nuclear Ribonucleoproteins
Gene expression
Switches
Gene Expression
15 Citations (Scopus)

Tryptophan-based fluorophores for studying protein conformational changes

Talukder, P., Chen, S., Liu, C. T., Baldwin, E. A., Benkovic, S. J. & Hecht, S., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5924-5934 11 p.

Research output: Contribution to journalArticle

Fluorophores
Tryptophan
Fluorescence
Proteins
Enzyme activity
2013
9 Citations (Scopus)

An optimized pyrimidinol multifunctional radical quencher

Khdour, O., Arce, P. M., Roy, B. & Hecht, S., Aug 8 2013, In : ACS Medicinal Chemistry Letters. 4, 8, p. 724-729 6 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
coenzyme Q10
Oxidative stress
Lymphocytes
Antioxidants
2 Citations (Scopus)

A structurally simplified analogue of geldanamycin exhibits neuroprotective activity

Madathil, M. M., Khdour, O., Jaruvangsanti, J. & Hecht, S., Oct 10 2013, In : ACS Medicinal Chemistry Letters. 4, 10, p. 953-957 5 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Lymphocytes
Cytoprotection
Mitochondrial Membrane Potential
Cytotoxicity
Antineoplastic Agents
Tumors
Carbohydrates
Bleomycin
Methotrexate
14 Citations (Scopus)

Characterization of Bleomycin-Mediated Cleavage of a Hairpin DNA Library

Segerman, Z. J., Roy, B. & Hecht, S., Aug 6 2013, In : Biochemistry. 52, 31, p. 5315-5327 13 p.

Research output: Contribution to journalArticle

Bleomycin
Gene Library
DNA
DNA Cleavage
DNA Damage