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2019

Genetic characterization of a recombinant myxoma virus in the iberian hare (Lepus granatensis)

Águeda-Pinto, A., Matos, A. L. D., Abrantes, M., Kraberger, S., Risalde, M. A., Gortázar, C., McFadden, D., Varsani, A. & Esteves, P. J., Jun 1 2019, In : Viruses. 11, 6, 530.

Research output: Contribution to journalArticle

Open Access
Myxoma virus
Hares
Rabbits
Spain
Genes

Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?

Yaron, J. R., Kwiecien, J. M., Zhang, L., Ambadapadi, S., Wakefield, D. N., Clapp, W. L., Dabrowski, W., Burgin, M., Munk, B. H., McFadden, D., Chen, H. & Lucas, A. R., Jan 1 2019, In : Trends in Molecular Medicine.

Research output: Contribution to journalReview article

Transplants
Glycocalyx
Tissue Survival
Graft Rejection
Organ Transplantation

Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs

Garg, R. R., Jackson, C. B., Rahman, M., Khan, A. R., Lewin, A. S. & McFadden, D., Jan 1 2019, In : Journal of Biological Chemistry. 294, 21, p. 8480-8489 10 p.

Research output: Contribution to journalArticle

Myxoma virus
Inflammasomes
Viruses
Aspartic Acid
Glutamic Acid

Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival

Kellish, P., Shabashvili, D., Rahman, M., Nawab, A., Guijarro, M. V., Zhang, M., Cao, C., Moussatche, N., Boyle, T., Antonia, S., Reinhard, M., Hartzell, C., Jantz, M., Mehta, H. J., McFadden, D., Kaye, F. J. & Zajac-Kaye, M., Apr 29 2019, In : The Journal of clinical investigation. 130

Research output: Contribution to journalArticle

Open Access
Oncolytic Virotherapy
Myxoma virus
Small Cell Lung Carcinoma
Survival
Neoplasms
3 Citations (Scopus)

Parallel adaptation of rabbit populations to myxoma virus

Alves, J. M., Carneiro, M., Cheng, J. Y., de Matos, A. L., Rahman, M., Loog, L., Campos, P. F., Wales, N., Eriksson, A., Manica, A., Strive, T., Graham, S. C., Afonso, S., Bell, D. J., Belmont, L., Day, J. P., Fuller, S. J., Marchandeau, S., Palmer, W. J., Queney, G. & 9 others, Surridge, A. K., Vieira, F. G., McFadden, D., Nielsen, R., Thomas, M., Gilbert, P., Esteves, P. J., Ferrand, N. & Jiggins, F. M., Mar 22 2019, In : Science. 363, 6433, p. 1319-1326 8 p.

Research output: Contribution to journalArticle

Myxoma virus
Rabbits
Exome
Viral Genes
Pandemics

Poxvirus oncolytic virotherapy

Torres-Domínguez, L. E. & McFadden, D., Jun 3 2019, In : Expert Opinion on Biological Therapy. 19, 6, p. 561-573 13 p.

Research output: Contribution to journalReview article

Oncolytic Virotherapy
Poxviridae
Tumors
Viruses
Neoplasms

Quantifying Antibody Responses Induced by Antigen-Agnostic Immunotherapies

van Vloten, J. P., Klafuric, E. M., Karimi, K., McFadden, D., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Sep 13 2019, In : Molecular Therapy - Methods and Clinical Development. 14, p. 189-196 8 p.

Research output: Contribution to journalArticle

Open Access
Immunotherapy
Antibody Formation
Antigens
Antibodies
Viruses
1 Citation (Scopus)

Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies

van Vloten, J. P., Santry, L. A., McAusland, T. M., Karimi, K., McFadden, D., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Jun 14 2019, In : Molecular Therapy - Methods and Clinical Development. 13, p. 154-166 13 p.

Research output: Contribution to journalArticle

Immunotherapy
T-Lymphocytes
Antigens
Neoplasm Antigens
Neoplasms
2018
5 Citations (Scopus)

Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function

Mahon, B. P., Ambadapadi, S., Yaron, J. R., Lomelino, C. L., Pinard, M. A., Keinan, S., Kurnikov, I., Macaulay, C., Zhang, L., Reeves, W., McFadden, D., Tibbetts, S., McKenna, R. & Lucas, A. R., Feb 20 2018, In : Biochemistry. 57, 7, p. 1096-1107 12 p.

Research output: Contribution to journalArticle

Serpins
Structural design
Crystal structure
Peptides
Therapeutics
2 Citations (Scopus)

Oncolytic Virus-Mediated RAS Targeting in Rhabdomyosarcoma

Phelps, M. P., Yang, H., Patel, S., Rahman, M., McFadden, D. & Chen, E., Dec 21 2018, In : Molecular Therapy - Oncolytics. 11, p. 52-61 10 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Embryonal Rhabdomyosarcoma
Rhabdomyosarcoma
Myxoma virus
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

Serpins: Development for therapeutic applications

Lucas, A., Yaron, J. R., Zhang, L., Macaulay, C. & McFadden, D., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 255-265 11 p. (Methods in Molecular Biology; vol. 1826).

Research output: Chapter in Book/Report/Conference proceedingChapter

Serpins
Therapeutics
Viruses
Serine Proteinase Inhibitors
Serine Proteases
9 Citations (Scopus)

The wide utility of rabbits as models of human diseases

Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., González-Gallego, J., Giacani, L., Hu, J., Kaplan, G., Keppler, O. T., Knight, K. L., Kong, X. P., Lanning, D. K., Le Pendu, J., De Matos, A. L., Liu, J., Liu, S., Lopes, A. M., Lu, S. & 17 others, Lukehart, S., Manabe, Y. C., Neves, F., McFadden, D., Pan, R., Peng, X., de Sousa-Pereira, P., Pinheiro, A., Rahman, M., Ruvoën-Clouet, N., Subbian, S., Tuñón, M. J., van der Loo, W., Vaine, M., Via, L. E., Wang, S. & Mage, R., May 1 2018, In : Experimental and Molecular Medicine. 50, 5, 66.

Research output: Contribution to journalArticle

Rabbits
Virus Diseases
Vaccines
Acquired Immunodeficiency Syndrome
Rabies Vaccines

Virotherapy as Potential Adjunct Therapy for Graft-Vs-Host Disease

Villa, N. & McFadden, D., Dec 1 2018, In : Current Pathobiology Reports. 6, 4, p. 247-263 17 p.

Research output: Contribution to journalReview article

Open Access
Graft vs Host Disease
Oncolytic Viruses
Myxoma virus
Hematopoietic Stem Cell Transplantation
Oncolytic Virotherapy
2 Citations (Scopus)

White paper on microbial anti-cancer therapy and prevention

Forbes, N. S., Coffin, R. S., Deng, L., Evgin, L., Fiering, S., Giacalone, M., Gravekamp, C., Gulley, J. L., Gunn, H., Hoffman, R. M., Kaur, B., Liu, K., Lyerly, H. K., Marciscano, A. E., Moradian, E., Ruppel, S., Saltzman, D. A., Tattersall, P. J., Thorne, S., Vile, R. G. & 3 others, Zhang, H. H., Zhou, S. & McFadden, D., Aug 6 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 78.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
Research Personnel
National Cancer Institute (U.S.)
Safety
2017
11 Citations (Scopus)

Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor

Lilly, C. L., Villa, N., Lemos de Matos, A., Ali, H. M., Dhillon, J. K. S., Hofland, T., Rahman, M., Chan, W., Bogen, B., Cogle, C. & McFadden, D., Mar 1 2017, In : Molecular Therapy - Oncolytics. 4, p. 31-40 10 p.

Research output: Contribution to journalArticle

Myxoma virus
Oncolytic Virotherapy
Multiple Myeloma
Leukocytes
Arm
5 Citations (Scopus)

Identification of host DEAD-box RNA helicases that regulate cellular tropism of oncolytic Myxoma virus in human cancer cells

Rahman, M., Bagdassarian, E., Ali, M. A. M. & McFadden, D., Dec 1 2017, In : Scientific Reports. 7, 1, 15710.

Research output: Contribution to journalArticle

Myxoma virus
DEAD-box RNA Helicases
Oncolytic Viruses
Tropism
RNA Helicases
2 Citations (Scopus)
Myxoma virus
Interferon Type I
RNA-Binding Proteins
Antiviral Agents
Protein Kinases
2016
9 Citations (Scopus)

Ex vivo virotherapy with myxoma virus does not impair hematopoietic stem and progenitor cells

Villa, N., Bais, S., Chan, W. M., Meacham, A. M., Wise, E., Rahman, M., Moreb, J. S., Rosenau, E. H., Wingard, J. R., McFadden, D. & Cogle, C. R., Mar 1 2016, In : Cytotherapy. 18, 3, p. 465-480 16 p.

Research output: Contribution to journalArticle

Myxoma virus
Hematopoietic Stem Cells
Virus Diseases
Hematologic Neoplasms
Transplants
7 Citations (Scopus)

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

Pisklakova, A., McKenzie, B., Zemp, F., Lun, X., Kenchappa, R. S., Etame, A. B., Rahman, M., Reilly, K., Pilon-Thomas, S., McFadden, D., Kurz, E. & Forsyth, P. A., Aug 1 2016, In : Neuro-Oncology. 18, 8, p. 1088-1098 11 p.

Research output: Contribution to journalArticle

Myxoma virus
Oncolytic Viruses
Neoplastic Stem Cells
Glioblastoma
Brain Neoplasms
19 Citations (Scopus)
Myxoma virus
Protein Kinase Inhibitors
Rabbits
Viruses
Protein Kinases

Tanapox virus

Barrett, J. W. & McFadden, D., Apr 19 2016, Molecular Detection of Human Viral Pathogens. CRC Press, p. 1039-1046 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yatapoxvirus
Viruses
Tanapox virus
4 Citations (Scopus)

Therapeutics for graft-versus-host disease: From conventional therapies to novel virotherapeutic strategies

Villa, N., Rahman, M., McFadden, D. & Cogle, C. R., Mar 1 2016, In : Viruses. 8, 3, 85.

Research output: Contribution to journalReview article

Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Myxoma virus
Oncolytic Viruses
Transplants
2 Citations (Scopus)

Vaccinia virus dissemination requires p21-activated kinase 1

Andrade, L. G., Albarnaz, J. D., Mügge, F. L. B., David, B. A., Abrahão, J. S., da Fonseca, F. G., Kroon, E. G., Menezes, G. B., McFadden, D. & Bonjardim, C. A., Nov 1 2016, In : Archives of Virology. 161, 11, p. 2991-3002 12 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
Vaccinia virus
Virion
Virus Internalization
Actins
2015
6 Citations (Scopus)

Editorial overview: Oncolytic viruses - Replicating virus therapeutics for the treatment of cancer

Bell, J. C. & McFadden, D., Aug 22 2015, In : Current Opinion in Virology. 13, p. viii-ix

Research output: Contribution to journalEditorial

Oncolytic Virotherapy
Oncolytic Viruses
Virus Replication
Viruses
Neoplasms
13 Citations (Scopus)

Evidence for differential viral oncolytic efficacy in an in vitro model of epithelial ovarian cancer metastasis

Tong, J. G., Valdes, Y. R., Barrett, J. W., Bell, J. C., Stojdl, D., McFadden, D., McCart, J. A., DiMattia, G. E. & Shepherd, T. G., Sep 23 2015, In : Molecular Therapy - Oncolytics. 2, 1 p., 15013.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Myxoma virus
Ovarian Neoplasms
Viruses
Vaccinia virus
10 Citations (Scopus)

Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation

Ildefonso, C. J., Jaime, H., Rahman, M., Li, Q., Boye, S. E., Hauswirth, W. W., Lucas, A. R., McFadden, D. & Lewin, A. S., Jan 1 2015, In : Human Gene Therapy. 26, 1, p. 59-68 10 p.

Research output: Contribution to journalArticle

Uveitis
Green Fluorescent Proteins
Interleukin-1
Endotoxins
Anti-Inflammatory Agents

Introducing “Research Matters”

McFadden, D. & Haldar, K., Jan 1 2015, In : PLoS Pathogens. 11, 6, e1005014.

Research output: Contribution to journalEditorial

Research
16 Citations (Scopus)

In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells

McKenzie, B. A., Zemp, F. J., Pisklakova, A., Narendran, A., McFadden, D., Lun, X., Kenchappa, R. S., Kurz, E. U. & Forsyth, P. A., Jan 1 2015, In : Neuro-Oncology. 17, 8, p. 1086-1094 9 p.

Research output: Contribution to journalArticle

Myxoma virus
Oncolytic Viruses
Neoplastic Stem Cells
Brain Neoplasms
Glioma
11 Citations (Scopus)

Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells

Villa, N., Wasserfall, C. H., Meacham, A. M., Wise, E., Chan, W., Wingard, J. R., McFadden, D. & Cogle, C. R., Jun 11 2015, In : Blood. 125, 24, p. 3778-3788 11 p.

Research output: Contribution to journalArticle

Myxoma virus
Oncolytic Viruses
T-cells
Viruses
Grafts
4 Citations (Scopus)
Myxoma virus
Oncolytic Viruses
Transplants
Human Herpesvirus 4
Viruses
28 Citations (Scopus)

SAMD9 is an innate antiviral host factor with stress response properties that can be antagonized by poxviruses

Liu, J. & McFadden, D., Jan 1 2015, In : Journal of Virology. 89, 3, p. 1925-1931 7 p.

Research output: Contribution to journalArticle

Poxviridae
Antiviral Agents
granules
stress response
Myxoma virus
1 Citation (Scopus)

Serpins, viruses, and the virome: New directions in therapy

Ambadapadi, S., Chen, H., Zheng, D., Liu, L., Dai, E., Munuswamy-Ramanujam, G., Morshed, S., Fuentes, J., Fortunel, A., Al-Ani, M., Kesavalu, L., McFadden, D. & Lucas, A., Jan 1 2015, The Serpin Family: Proteins with Multiple Functions in Health and Disease. Springer International Publishing, p. 293-329 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Serpins
Viruses
Therapeutics
Inflammation
Peptide Hydrolases
1 Citation (Scopus)

The Curious Road from Basic Pathogen Research to Clinical Translation

McFadden, D., Jan 1 2015, In : PLoS Pathogens. 11, 6, e1004997.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Translational Medical Research
Virus Diseases
Rabbits
3 Citations (Scopus)

The α2,3-sialyltransferase encoded by myxoma virus is a virulence factor that contributes to immunosuppression

Boutard, B., Vankerckhove, S., Markine-Goriaynoff, N., Sarlet, M., Desmecht, D., McFadden, D., Vanderplasschen, A. & Gillet, L., Feb 23 2015, In : PLoS One. 10, 2, e0118806.

Research output: Contribution to journalArticle

Myxoma virus
Sialyltransferases
immunosuppression
Virulence Factors
Viruses
2014
13 Citations (Scopus)

Are We There Yet? The Smallpox Research Agenda Using Variola Virus

Damon, I. K., Damaso, C. R. & McFadden, D., Jan 1 2014, In : PLoS Pathogens. 10, 5, e1004108.

Research output: Contribution to journalArticle

Poxviridae Infections
Variola virus
Orthopoxvirus
Smallpox Vaccine
Disease Eradication
10 Citations (Scopus)

Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus

Zemp, F. J., McKenzie, B. A., Lun, X., Reilly, K. M., McFadden, D., Yong, V. W. & Forsyth, P. A., Dec 15 2014, In : Cancer Research. 74, 24, p. 7260-7273 14 p.

Research output: Contribution to journalArticle

Myxoma virus
Oncolytic Viruses
R Factors
Glioma
Virus Diseases
16 Citations (Scopus)

Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus

Lemos De Matos, A., McFadden, D. & Esteves, P. J., Jan 1 2014, In : Immunogenetics. 66, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

Myxoma virus
Lagomorpha
Hares
Leporipoxvirus
Rabbits
15 Citations (Scopus)

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, D., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PLoS One. 9, 10, e109801.

Research output: Contribution to journalArticle

Interleukin-15 Receptor alpha Subunit
Myxoma virus
viral fusion proteins
Interleukin-15
Viruses
40 Citations (Scopus)

Oncolytic poxviruses

Chan, W. M. & McFadden, D., Sep 29 2014, In : Annual Review of Virology. 1, 1, p. 191-214 24 p.

Research output: Contribution to journalArticle

Poxviridae
Oncolytic Virotherapy
Neoplasms
Myxoma virus
Oncolytic Viruses
73 Citations (Scopus)

Poxviruses and the evolution of host range and virulence

Haller, S. L., Peng, C., McFadden, D. & Rothenburg, S., Jan 1 2014, In : Infection, Genetics and Evolution. 21, p. 15-40 26 p.

Research output: Contribution to journalReview article

Poxviridae
Host Specificity
host range
virulence
Virulence
6 Citations (Scopus)
Myxoma virus
Ankyrin Repeat
Poxviridae
Virulence
Proteins
38 Citations (Scopus)

Scalable collaborative infrastructure for a learning healthcare system (SCILHS): Architecture

Mandl, K. D., Kohane, I. S., McFadden, D., Weber, G. M., Natter, M., Mandel, J., Schneeweiss, S., Weiler, S., Klann, J. G., Bickel, J., Adams, W. G., Ge, Y., Zhou, X., Perkins, J., Marsolo, K., Berns tam, E., Showalter, J., Quarshie, A., Ofili, E., Hripcsak, G. & 1 others, Murphy, S. N., Jan 1 2014, In : Journal of the American Medical Informatics Association. 21, 4, p. 615-620 6 p.

Research output: Contribution to journalArticle

Learning
Delivery of Health Care
Point-of-Care Systems
Research
Patient Outcome Assessment
4 Citations (Scopus)

Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus

Brahn, E., Lee, S., Lucas, A., McFadden, D. & MaCaulay, C., Jan 1 2014, In : Clinical Immunology. 153, 2, p. 254-263 10 p.

Research output: Contribution to journalArticle

Myxoma virus
Serine Proteinase Inhibitors
Experimental Arthritis
Collagen Type II
Joint Diseases
10 Citations (Scopus)

Targeting gallbladder cancer: Oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo

Weng, M., Gong, W., Ma, M., Chu, B., Qin, Y., Zhang, M., Lun, X., McFadden, D., Forsyth, P., Yang, Y. & Quan, Z., Apr 13 2014, In : Molecular Cancer. 13, 1, 82.

Research output: Contribution to journalArticle

Myxoma virus
Oncolytic Virotherapy
Gallbladder Neoplasms
Sirolimus
Hyaluronic Acid
1 Citation (Scopus)

The virome: Viral ghost companion, virus wars

Lucas, A., Ambadapadi, S., Zheng, D., Chen, H., Lakshmyya, K., Progulske-Fox, A., Krafft, A., Bryant, M., O’Regan, S., Moyer, R., McFadden, D., Jobin, C. & Rand, K., Jan 1 2014, In : Journal of Clinical and Experimental Cardiology. 5, 8, e136.

Research output: Contribution to journalEditorial

Viruses
Warfare
3 Citations (Scopus)

Viral anti-inflammatory proteins target diverging immune pathways with converging effects on arterial dilatation, plaque and apoptosis

Davids, J. A., Dai, E., Chen, H., Bartee, M. Y., Liu, L., Fortunel, A., Moyer, R., McFadden, D. & Lucas, A. R., Jan 1 2014, In : European Journal of Inflammation. 12, 1, p. 131-145 15 p.

Research output: Contribution to journalArticle

Dilatation
Anti-Inflammatory Agents
Apoptosis
Serine Proteinase Inhibitors
Chemokines
58 Citations (Scopus)

Viruses for tumor therapy

Bell, J. & McFadden, D., Mar 12 2014, In : Cell Host and Microbe. 15, 3, p. 260-265 6 p.

Research output: Contribution to journalShort survey

Oncogenic Viruses
Oncolytic Virotherapy
Oncolytic Viruses
Neoplasms
Immune Tolerance

Women in cardiology: The x factor and the heart of medicine

Lucas, A., Eaverly, M., McFadden, D. & Bryant, M., Jan 1 2014, In : Journal of Clinical and Experimental Cardiology. 5, 2

Research output: Contribution to journalEditorial

Cardiology
Medicine
2013
13 Citations (Scopus)

Cytokine synergy: An underappreciated contributor to innate anti-viral immunity

Bartee, E. & McFadden, D., Sep 1 2013, In : Cytokine. 63, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

Immunity
Cytokines
Interferons
Cultured Cells
Tumor Necrosis Factor-alpha
20 Citations (Scopus)

Evolution and divergence of the mammalian SAMD9/SAMD9L gene family

Lemos De Matos, A., Liu, J., McFadden, D. & Esteves, P. J., Jun 17 2013, In : BMC Evolutionary Biology. 13, 1, 121.

Research output: Contribution to journalArticle

divergence
gene
genes
Mus musculus
immune response