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2018
2 Citations (Scopus)

Antineoplastic Agents. 605. Isoquinstatins

Pettit, G., Melody, N. & Chapuis, J., Mar 23 2018, In : Journal of Natural Products. 81, 3, p. 451-457 7 p.

Research output: Contribution to journalArticle

dolastatin 10
Antineoplastic Agents
Hares
Indian Ocean
Growth Inhibitors
2 Citations (Scopus)

Antineoplastic Agents. 606. the Betulastatins

Pettit, G., Melody, N. & Chapuis, J., Mar 23 2018, In : Journal of Natural Products. 81, 3, p. 458-464 7 p.

Research output: Contribution to journalArticle

dolastatin 10
Antineoplastic Agents
Pentacyclic Triterpenes
Growth Inhibitors
Cell growth
2017
7 Citations (Scopus)

Antineoplastic Agents. 603. Quinstatins: Exceptional Cancer Cell Growth Inhibitors

Pettit, G., Melody, N. & Chapuis, J., Mar 24 2017, In : Journal of Natural Products. 80, 3, p. 692-698 7 p.

Research output: Contribution to journalReview article

dolastatin 10
Growth Inhibitors
Antineoplastic Agents
Pharmaceutical Preparations
Neoplasms
1 Citation (Scopus)

Antineoplastic Agents. 604. the Path of Quinstatin Derivatives to Antibody Drug Conjugates

Pettit, G., Melody, N. & Chapuis, J., Jan 1 2017, In : Journal of Natural Products. 80, 9, p. 2447-2452 6 p.

Research output: Contribution to journalArticle

dolastatin 10
Antineoplastic Agents
Derivatives
Antibodies
Cell growth
2016
7 Citations (Scopus)

Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications

Pettit, G., Searcy, J. D., Tan, R., Cragg, G. M., Melody, N., Knight, J. C. & Chapuis, J., Mar 25 2016, In : Journal of Natural Products. 79, 3, p. 507-518 12 p.

Research output: Contribution to journalArticle

Podophyllotoxin
Antineoplastic Agents
Cell growth
Fractionation
Growth
1 Citation (Scopus)

Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae

Pettit, G., Ye, Q., Herald, D. L., Knight, J. C., Hogan, F., Melody, N., Mukku, V. J. R. V., Doubek, D. L. & Chapuis, J., Jun 24 2016, In : Journal of Natural Products. 79, 6, p. 1598-1603 6 p.

Research output: Contribution to journalArticle

Triterpenes
Cell growth
Growth
Neoplasms
Medicinal Plants
2015
11 Citations (Scopus)

Antineoplastic agents. 599. Total synthesis of dolastatin 16

Pettit, G., Smith, T. H., Arce, P. M., Flahive, E. J., Anderson, C. R., Chapuis, J., Xu, J-P., Groy, T. L., Belcher, P. E. & Macdonald, C. B., Mar 27 2015, In : Journal of Natural Products. 78, 3, p. 476-485 10 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Biological Products
Depsipeptides
Cell growth
Conformations
4 Citations (Scopus)

Antineoplastic agents. 600. from the south pacific ocean to the silstatins

Pettit, G., Arce, P. M., Chapuis, J. & Macdonald, C. B., Mar 27 2015, In : Journal of Natural Products. 78, 3, p. 510-523 14 p.

Research output: Contribution to journalArticle

Pacific Ocean
Antineoplastic Agents
Growth Inhibitors
Oncology
Antibodies
2 Citations (Scopus)

Antineoplastic agents 596. Isolation and structure of chromomycin A5 from a Beaufort Sea microorganism

Pettit, G., Tan, R., Pettit, R., Doubek, D. L., Chapuis, J. & Weber, C. A., 2015, In : RSC Advances. 5, 12, p. 9116-9122 7 p.

Research output: Contribution to journalArticle

Chromomycins
Microorganisms
Antineoplastic Agents
Cells
Cell growth
13 Citations (Scopus)

Neristatin 1 Provides Critical Insight into Bryostatin 1 Structure-Function Relationships

Kedei, N., Kraft, M. B., Keck, G. E., Herald, C. L., Melody, N., Pettit, G. & Blumberg, P. M., Apr 24 2015, In : Journal of Natural Products. 78, 4, p. 896-900 5 p.

Research output: Contribution to journalArticle

Protein Kinase C
Phorbol Esters
Activator Appliances
neristatin 1
bryostatin 1
8 Citations (Scopus)

The cephalostatins. 23. Conversion of hecogenin to a steroidal 1,6-dioxaspiro[5.5]nonane analogue for cephalostatin 11

Pettit, G., Moser, B. R., Herald, D. L., Knight, J. C., Chapuis, J. & Zheng, X., May 22 2015, In : Journal of Natural Products. 78, 5, p. 1067-1072 6 p.

Research output: Contribution to journalArticle

Pyrazines
Lymphoid Leukemia
Growth Inhibitors
Alkaloids
Neoplasms
9 Citations (Scopus)

The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20

Pettit, G., Xu, J-P., Chapuis, J. & Melody, N., Jun 26 2015, In : Journal of Natural Products. 78, 6, p. 1446-1450 5 p.

Research output: Contribution to journalArticle

Cell growth
Cells
Growth
Neoplasms
Cell Line
2014
23 Citations (Scopus)

Antineoplastic agents. 595. structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer1

Pettit, G., Melody, N., Hempenstall, F., Chapuis, J., Groy, T. L. & Williams, L., Apr 25 2014, In : Journal of Natural Products. 77, 4, p. 863-872 10 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Amines
Crystal structure
X-Rays
X rays
2013
18 Citations (Scopus)

Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel(1)

Pettit, G., Tang, Y., Zhang, Q., Bourne, G. T., Arm, C. A., Leet, J. E., Knight, J. C., Pettit, R., Chapuis, J., Doubek, D. L., Ward, F. J., Weber, C. & Hooper, J. N. A., Mar 22 2013, In : Journal of Natural Products. 76, 3, p. 420-424 5 p.

Research output: Contribution to journalArticle

Agelas
Palau
Cell growth
Porifera
Formamides
34 Citations (Scopus)

Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent

Hadimani, M. B., MacDonough, M. T., Ghatak, A., Strecker, T. E., Lopez, R., Sriram, M., Nguyen, B. L., Hall, J. J., Kessler, R. J., Shirali, A. R., Liu, L., Garner, C. M., Pettit, G., Hamel, E., Chaplin, D. J., Mason, R. P., Trawick, M. L. & Pinney, K. G., Sep 27 2013, In : Journal of Natural Products. 76, 9, p. 1668-1678 11 p.

Research output: Contribution to journalArticle

Prodrugs
Blood Vessels
Salts
Phosphates
Phenol
2012
6 Citations (Scopus)

Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs

Pettit, G., Rosenberg, H. J., Dixon, R., Knight, J. C., Hamel, E., Chapuis, J., Pettit, R., Hogan, F., Sumner, B., Ain, K. B. & Trickey-Platt, B., Mar 23 2012, In : Journal of Natural Products. 75, 3, p. 385-393 9 p.

Research output: Contribution to journalArticle

Prodrugs
Antineoplastic Agents
Phosphates
Cells
Cell Line
9 Citations (Scopus)

Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies(1)

Pettit, G., Tan, R., Bao, G. H., Melody, N., Doubek, D. L., Gao, S., Chapuis, J. & Williams, L., Apr 27 2012, In : Journal of Natural Products. 75, 4, p. 771-773 3 p.

Research output: Contribution to journalArticle

Narcissus
Ice
Antineoplastic Agents
Cell growth
Cells
6 Citations (Scopus)

Preclinical efficacy of sodium narcistatin to reduce inflammation and joint destruction in rats with adjuvant-induced arthritis

Lubahn, C., Schaller, J. A., Shewmacker, E., Wood, C., Bellinger, D. L., Byron, D., Melody, N., Pettit, G. & Lorton, D., Dec 2012, In : Rheumatology International. 32, 12, p. 3751-3760 10 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Joints
Sodium
Inflammation
Cytokines
12 Citations (Scopus)

The Cephalostatins. 22. Synthesis of bis-steroidal pyrazine pyrones

Pettit, G., Moser, B. R., Mendonça, R. F., Knight, J. C. & Hogan, F., Jun 22 2012, In : Journal of Natural Products. 75, 6, p. 1063-1069 7 p.

Research output: Contribution to journalArticle

Pyrones
Pyrazines
Cell growth
Antineoplastic Agents
Dihydrotestosterone
2011
7 Citations (Scopus)

A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids

Abi-Ghanem, D., Lai, X., Berghman, L. R., Horvat, D., Li, J., Romo, D., Uddin, M. N., Kamano, Y., Nogawa, T., Xu, J-P., Pettit, G. & Puschett, J. B., Jan 2011, In : Journal of Immunoassay and Immunochemistry. 32, 1, p. 31-46 16 p.

Research output: Contribution to journalArticle

Body fluids
Body Fluids
Immunoassay
Assays
Urine
11 Citations (Scopus)

Antineoplastic agents. 590. X-ray crystal structure of dolastatin 16 and syntheses of the dolamethylleuine and dolaphenvaline units

Pettit, G., Smith, T. H., Xu, J-P., Herald, D. L., Flahive, E. J., Anderson, C. R., Belcher, P. E. & Knight, J. C., May 27 2011, In : Journal of Natural Products. 74, 5, p. 1003-1008 6 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Crystal structure
X-Rays
X rays
Amino Acids
26 Citations (Scopus)

Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications of dolastatin 10

Pettit, G., Hogan, F. & Toms, S., May 27 2011, In : Journal of Natural Products. 74, 5, p. 962-968 7 p.

Research output: Contribution to journalArticle

dolastatin 10
Cell growth
Antineoplastic Agents
Growth
Neoplasms
36 Citations (Scopus)

Interactions of halichondrin B and eribulin with tubulin

Bai, R., Nguyen, T. L., Burnett, J. C., Atasoylu, O., Munro, M. H. G., Pettit, G., Smith, A. B., Gussio, R. & Hamel, E., Jun 27 2011, In : Journal of Chemical Information and Modeling. 51, 6, p. 1393-1404 12 p.

Research output: Contribution to journalArticle

eribulin
Tubulin
drug
High performance liquid chromatography
Binding sites
12 Citations (Scopus)

Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1

Tanpure, R. P., Nguyen, B. L., Strecker, T. E., Aguirre, S., Sharma, S., Chaplin, D. J., Siim, B. G., Hamel, E., Lippert, J. W., Pettit, G., Trawick, M. L. & Pinney, K. G., Jul 22 2011, In : Journal of Natural Products. 74, 7, p. 1568-1574 7 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Diphosphates
Derivatives
Water
Neoplasms
16 Citations (Scopus)

The cephalostatins. 21. Synthesis of bis-steroidal pyrazine rhamnosides (1)

Pettit, G., Mendonca, R. F., Knight, J. C. & Pettit, R., Sep 23 2011, In : Journal of Natural Products. 74, 9, p. 1922-1930 9 p.

Research output: Contribution to journalArticle

Pyrazines
Rhamnose
Glycosylation
Iodides
Boron
2010
10 Citations (Scopus)

An efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin a-4 phosphate and other Z-combretastatins

Pettit, G., Minardi, M. D., Hogan, F. & Price, P. M., Mar 26 2010, In : Journal of Natural Products. 73, 3, p. 399-403 5 p.

Research output: Contribution to journalArticle

Carbon Isotopes
Isotope Labeling
Positron emission tomography
Isomerization
Isotopes
19 Citations (Scopus)

Antineoplastic agents. 556. Isolation and structure of coprinastatin 1 from coprinus cinereus

Pettit, G., Meng, Y., Pettit, R., Herald, D. L., Cichacz, Z., Doubek, D. L. & Richert, L., Mar 26 2010, In : Journal of Natural Products. 73, 3, p. 388-392 5 p.

Research output: Contribution to journalArticle

Coprinus
Sesquiterpenes
Antineoplastic Agents
Cells
Lymphoid Leukemia
6 Citations (Scopus)

Antineoplastic agents. 573. Isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa

Pettit, G., Ye, Q., Herald, D. L., Hogan, F. & Pettit, R., Feb 26 2010, In : Journal of Natural Products. 73, 2, p. 164-166 3 p.

Research output: Contribution to journalArticle

Butterflies
Antineoplastic Agents
Leukemia P388
Neoplasms
Growth Inhibitors
9 Citations (Scopus)

Antineoplastic agents 582. Part 1: Isolation and structure of a cyclobutane-type sesquiterpene cancer cell growth inhibitor from Coprinus cinereus (Coprinaceae)

Pettit, G., Meng, Y., Pettit, R., Herald, D. L., Hogan, F. & Cichacz, Z., Jul 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 14, p. 4879-4883 5 p.

Research output: Contribution to journalArticle

Coprinus
Cyclobutanes
Growth Inhibitors
Sesquiterpenes
Antineoplastic Agents
2 Citations (Scopus)

Cytotoxic lipid esters from Peucedanum ledebourielloides

Zheng, X., Du, J., Xu, Y., Liao, D. & Pettit, G., May 2010, In : Medicinal Chemistry Research. 19, 4, p. 337-343 7 p.

Research output: Contribution to journalArticle

Esters
Lipids
Glycerol
Apiaceae
Oleanolic Acid
11 Citations (Scopus)

Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture

Pettit, R., Pettit, G., Xu, J-P., Weber, C. A. & Richert, L. A., 2010, In : Planta Medica. 76, 5, p. 500-501 2 p.

Research output: Contribution to journalArticle

Cell growth
Fungi
Biosynthesis
Cells
Growth
7 Citations (Scopus)

Potentiation of the activity of cisplatin in a human colon tumour xenograft model by auristatin PYE, a structural modification of dolastatin 10

Prokopiou, E. M., Cooper, P. A., Pettit, G., Bibby, M. C. & Stevend, S. D., Mar 2010, In : Molecular Medicine Reports. 3, 2, p. 309-313 5 p.

Research output: Contribution to journalArticle

dolastatin 10
Heterografts
Cisplatin
Tumors
Colon