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  • Sidney Hecht

An acetate prodrug of a pyridinol-based vitamin e analogue

Khdour, O., Lu, J. & Hecht, S., Nov 1 2011, In : Pharmaceutical Research. 28, 11, p. 2896-2909 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection

Arce, P. M., Goldschmidt, R., Khdour, O., Madathil, M. M., Jaruvangsanti, J., Dey, S., Fash, D. M., Armstrong, J. S. & Hecht, S., Sep 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 17, p. 5188-5201 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

A new strategy for the synthesis of bisaminoacylated tRNAs

Nangreave, R. C., Dedkova, L., Chen, S. & Hecht, S., Sep 16 2011, In : Organic Letters. 13, 18, p. 4906-4909 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

An optimized pyrimidinol multifunctional radical quencher

Khdour, O., Arce, P. M., Roy, B. & Hecht, S., Aug 8 2013, In : ACS Medicinal Chemistry Letters. 4, 8, p. 724-729 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

Tang, C., Paul, A., Alam, M. P., Roy, B., Wilson, W. D. & Hecht, S., Sep 4 2014, In : Journal of the American Chemical Society. 136, 39, p. 13715-13726 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

A strategy for suppressing redox stress within mitochondria

Arce, P. M., Khdour, O., Goldschmidt, R., Armstrong, J. S. & Hecht, S., Aug 11 2011, In : ACS Medicinal Chemistry Letters. 2, 8, p. 608-613 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

A structurally simplified analogue of geldanamycin exhibits neuroprotective activity

Madathil, M. M., Khdour, O., Jaruvangsanti, J. & Hecht, S., Oct 10 2013, In : ACS Medicinal Chemistry Letters. 4, 10, p. 953-957 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Characterization of Bleomycin-Mediated Cleavage of a Hairpin DNA Library

Segerman, Z. J., Roy, B. & Hecht, S., Aug 6 2013, In : Biochemistry. 52, 31, p. 5315-5327 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P., Hecht, S. & Khdour, O., Oct 1 2018, In : Data in Brief. 20, p. 1105-1114 10 p.

Research output: Contribution to journalArticle

Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction

Talukder, P., Chen, S., Roy, B., Yakovchuk, P., Spiering, M. M., Alam, M. P., Madathil, M. M., Bhattacharya, C., Benkovic, S. J. & Hecht, S., Dec 29 2015, In : Biochemistry. 54, 51, p. 7457-7469 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases

Alam, M. P., Khdour, O., Arce, P. M., Chen, Y., Roy, B., Johnson, W. G., Dey, S. & Hecht, S., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4935-4947 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Deglycobleomycin A6 analogues modified in the methylvalerate moiety

Cai, X., Zaleski, P. A., Cagir, A. & Hecht, S., Jun 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 12, p. 3831-3844 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase

Bernatchez, J. A., Paul, R., Tchesnokov, E. P., Ngure, M., Beilhartz, G. L., Berghuis, A. M., Lavoie, R., Li, L., Auger, A., Melnyk, R. A., Grobler, J. A., Miller, M. D., Hazuda, D. J., Hecht, S. & Götte, M., Jan 16 2015, In : Journal of Biological Chemistry. 290, 3, p. 1474-1484 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Detection of dihydrofolate reductase conformational change by fret using two fluorescent amino acids

Chen, S., Fahmi, N. E., Wang, L., Bhattacharya, C., Benkovic, S. J. & Hecht, S., Sep 4 2013, In : Journal of the American Chemical Society. 135, 35, p. 12924-12927 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

DNA-affibody nanoparticles for inhibiting breast cancer cells overexpressing HER2

Zhang, Y., Jiang, S., Zhang, D., Bai, X., Hecht, S. & Chen, S., Jan 1 2017, In : Chemical Communications. 53, 3, p. 573-576 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

DNA methylation reduces binding and cleavage by bleomycin

Roy, B., Tang, C., Alam, M. P. & Hecht, S., Sep 30 2014, In : Biochemistry. 53, 38, p. 6103-6112 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA

Bozeman, T. C., Nanjunda, R., Tang, C., Liu, Y., Segerman, Z. J., Zaleski, P. A., Wilson, W. D. & Hecht, S., Oct 31 2012, In : Journal of the American Chemical Society. 134, 43, p. 17842-17845 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection

Fash, D. M., Khdour, O., Sahdeo, S. J., Goldschmidt, R., Jaruvangsanti, J., Dey, S., Arce, P. M., Collin, V. C., Cortopassi, G. A. & Hecht, S., Apr 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 8, p. 2346-2354 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases

Goldschmidt, R., Arce, P. M., Khdour, O., Collin, V. C., Dey, S., Jaruvangsanti, J., Fash, D. M. & Hecht, S., Feb 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 4, p. 969-978 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Efficient asymmetric synthesis of Tryptophan Analogues having useful Photophysical properties

Talukder, P., Chen, S., Arce, P. M. & Hecht, S., Mar 17 2014, In : Organic Letters. 16, 2, p. 556-559 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids

Bai, X., Talukder, P., Daskalova, S. M., Roy, B., Chen, S., Li, Z., Dedkova, L. & Hecht, S., Apr 5 2017, In : Journal of the American Chemical Society. 139, 13, p. 4611-4614 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Erratum: Characterization of bleomycin-mediated cleavage of a hairpin DNA library (Biochemistry (2013) 52:31 (5313-5327) DOI:10.1021/bi400779r)

Segerman, Z. J., Roy, B. & Hecht, S., Sep 10 2013, In : Biochemistry. 52, 36, 1 p.

Research output: Contribution to journalComment/debate

Expanding the Scope of Protein Synthesis Using Modified Ribosomes

Dedkova, L. & Hecht, S., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6430-6447 18 p.

Research output: Contribution to journalArticle

4 Scopus citations

Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensors

Gerasimova, Y. V., Yakovchuk, P., Dedkova, L., Hecht, S. & Kolpashchikov, D. M., Oct 1 2015, In : RNA. 21, 10, p. 1834-1843 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification

Chen, S., Fahmi, N. E., Bhattacharya, C., Wang, L., Jin, Y., Benkovic, S. J. & Hecht, S., Nov 26 2013, In : Biochemistry. 52, 47, p. 8580-8589 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Fluorescent CD4 probe for potential HIV-1 gp120 protein detection

Wang, Z., Talukder, P., Hecht, S. & Chen, S., Mar 15 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 6, p. 1182-1185 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Foreword

Hecht, S., Jul 25 2011, In : Unknown Journal.

Research output: Contribution to journalArticle

Hairpin DNA sequences bound strongly by bleomycin exhibit enhanced double-strand cleavage

Roy, B. & Hecht, S., Mar 19 2014, In : Journal of the American Chemical Society. 136, 11, p. 4382-4393 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Improving the affinity of SL0101 for RSK using structure-based design

Mrozowski, R. M., Vemula, R., Wu, B., Zhang, Q., Schroeder, B. R., Hilinski, M. K., Clark, D. E., Hecht, S., O'Doherty, G. A. & Lannigan, D. A., Feb 14 2013, In : ACS Medicinal Chemistry Letters. 4, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

In Cellulo Synthesis of Proteins Containing a Fluorescent Oxazole Amino Acid

Chen, S., Ji, X., Gao, M., Dedkova, L. & Hecht, S., Apr 10 2019, In : Journal of the American Chemical Society. 141, 14, p. 5597-5601 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB

Chen, S., Maini, R., Bai, X., Nangreave, R. C., Dedkova, L. & Hecht, S., Oct 11 2017, In : Journal of the American Chemical Society. 139, 40, p. 14098-14108 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center

Maini, R., Nguyen, D. T., Chen, S., Dedkova, L., Chowdhury, S. R., Alcala-Torano, R. & Hecht, S., Mar 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 5, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Influence of substituent heteroatoms on the cytoprotective properties of pyrimidinol antioxidants

Chevalier, A., Khdour, O., Schmierer, M., Bandyopadhyay, I. & Hecht, S., Mar 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 5, p. 1703-1716 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A

Zhang, Y., Chevalier, A., Khdour, O., Soto, L. M. & Hecht, S., May 20 2017, (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

1 Scopus citations

Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA

Roy, B., Talukder, P., Kang, H. J., Tsuen, S. S., Alam, M. P., Hurley, L. H. & Hecht, S., Aug 31 2016, In : Journal of the American Chemical Society. 138, 34, p. 10950-10962 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Lipophilic methylene blue analogues enhance mitochondrial function and increase frataxin levels in a cellular model of Friedreich's ataxia

Khdour, O., Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P. & Hecht, S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

4 Scopus citations

Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction

Roy Chowdhury, S., Khdour, O., Bandyopadhyay, I. & Hecht, S., Oct 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5537-5547 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting

Chevalier, A., Zhang, Y., Khdour, O., Kaye, J. B. & Hecht, S., Sep 21 2016, In : Journal of the American Chemical Society. 138, 37, p. 12009-12012 4 p.

Research output: Contribution to journalArticle

70 Scopus citations

Modified bleomycin disaccharides exhibiting improved tumor cell targeting

Madathil, M. M., Bhattacharya, C., Yu, Z., Paul, R., Rishel, M. J. & Hecht, S., Nov 4 2014, In : Biochemistry. 53, 43, p. 6800-6810 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction

Ji, X., Khdour, O. & Hecht, S., Jan 1 2019, In : Future Medicinal Chemistry. 11, 13, p. 1605-1624 20 p.

Research output: Contribution to journalReview article

10 Scopus citations

Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

Mastroeni, D., Khdour, O., Delvaux, E., Nolz, J., Olsen, G., Berchtold, N., Cotman, C., Hecht, S. & Coleman, P., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

23 Scopus citations

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Mastroeni, D., Nolz, J., Khdour, O., Sekar, S., Delvaux, E., Cuyugan, L., Liang, W. S., Hecht, S. & Coleman, P., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

8 Scopus citations

One-pot regio- and stereoselective synthesis of α′-methoxy- γ-pyrones: Biological evaluation as mitochondrial respiratory complex inhibitors

Rosso, H., De Paolis, M., Collin, V. C., Dey, S., Hecht, S., Prandi, C., Richard, V. & Maddaluno, J., Nov 18 2011, In : Journal of Organic Chemistry. 76, 22, p. 9429-9437 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability

Chevalier, A., Alam, M. P., Khdour, O., Schmierer, M., Arce, P. M., Cripe, C. D. & Hecht, S., Nov 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5206-5220 15 p.

Research output: Contribution to journalArticle

8 Scopus citations