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  • 2020
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  • Sidney Hecht
2016

Synthesis and evaluation of a library of fluorescent dipeptidomimetic analogues as substrates for modified bacterial ribosomes

Chowdhury, S. R., Chauhan, P. S., Dedkova, L., Bai, X., Chen, S., Talukder, P. & Hecht, S., May 3 2016, In : Biochemistry. 55, 17, p. 2427-2440 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Synthesis of alanyl nucleobase amino acids and their incorporation into proteins

Talukder, P., Dedkova, L., Ellington, A. D., Yakovchuk, P., Lim, J., Anslyn, E. V. & Hecht, S., Sep 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 18, p. 4177-4187 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Lipophilic methylene blue analogues enhance mitochondrial function and increase frataxin levels in a cellular model of Friedreich's ataxia

Khdour, O., Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P. & Hecht, S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

4 Scopus citations
2019

Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction

Ji, X., Khdour, O. & Hecht, S., Jan 1 2019, In : Future Medicinal Chemistry. 11, 13, p. 1605-1624 20 p.

Research output: Contribution to journalReview article

2017

Prescreening of Nicotine Hapten Linkers in Vitro To Select Hapten-Conjugate Vaccine Candidates for Pharmacokinetic Evaluation in Vivo

Arutla, V., Leal, J., Liu, X., Sokalingam, S., Raleigh, M., Adaralegbe, A., Liu, L., Pentel, P. R., Hecht, S. & Chang, Y., May 8 2017, In : ACS Combinatorial Science. 19, 5, p. 286-298 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Expanding the Scope of Protein Synthesis Using Modified Ribosomes

Dedkova, L. & Hecht, S., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6430-6447 18 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA

Roy, B., Talukder, P., Kang, H. J., Tsuen, S. S., Alam, M. P., Hurley, L. H. & Hecht, S., Aug 31 2016, In : Journal of the American Chemical Society. 138, 34, p. 10950-10962 13 p.

Research output: Contribution to journalArticle

25 Scopus citations
2020
2 Scopus citations
2017

DNA-affibody nanoparticles for inhibiting breast cancer cells overexpressing HER2

Zhang, Y., Jiang, S., Zhang, D., Bai, X., Hecht, S. & Chen, S., Jan 1 2017, In : Chemical Communications. 53, 3, p. 573-576 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction

Roy Chowdhury, S., Khdour, O., Bandyopadhyay, I. & Hecht, S., Oct 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5537-5547 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability

Chevalier, A., Alam, M. P., Khdour, O., Schmierer, M., Arce, P. M., Cripe, C. D. & Hecht, S., Nov 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5206-5220 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2018

Rapid detection of a dengue virus RNA sequence with single molecule sensitivity using tandem toehold-mediated displacement reactions

Gao, M., Daniel, D., Zou, H., Jiang, S., Lin, S., Huang, C., Hecht, S. & Chen, S., Jan 1 2018, In : Chemical Communications. 54, 8, p. 968-971 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

Mastroeni, D., Khdour, O., Delvaux, E., Nolz, J., Olsen, G., Berchtold, N., Cotman, C., Hecht, S. & Coleman, P., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A

Zhang, Y., Chevalier, A., Khdour, O., Soto, L. M. & Hecht, S., May 20 2017, (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Phenothiazine antioxidants increase mitochondrial biogenesis and frataxin levels in Friedreich's ataxia cells

Khdour, O., Bandyopadhyay, I., Visavadiya, N. P., Roy Chowdhury, S. & Hecht, S., Jan 1 2018, In : MedChemComm. 9, 9, p. 1491-1501 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Selective Detection of Dengue Virus Serotypes Using Tandem Toehold-Mediated Displacement Reactions

Gao, M., Waggoner, J. J., Hecht, S. M. & Chen, S., Nov 8 2019, In : ACS Infectious Diseases. 5, 11, p. 1907-1914 8 p.

Research output: Contribution to journalArticle

2016

Selective Functionalization of Antimycin A Through an N-Transacylation Reaction

Chevalier, A., Zhang, Y., Khdour, O. & Hecht, S., May 20 2016, In : Organic Letters. 18, 10, p. 2395-2398 4 p.

Research output: Contribution to journalArticle

6 Scopus citations
2019

In Cellulo Synthesis of Proteins Containing a Fluorescent Oxazole Amino Acid

Chen, S., Ji, X., Gao, M., Dedkova, L. & Hecht, S., Apr 10 2019, In : Journal of the American Chemical Society. 141, 14, p. 5597-5601 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Study of the Lyase Activity of Human DNA Polymerase β Using Analogues of the Intermediate Schiff Base Complex

Daskalova, S. M., Bai, X. & Hecht, S., May 8 2018, In : Biochemistry. 57, 18, p. 2711-2722 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Influence of substituent heteroatoms on the cytoprotective properties of pyrimidinol antioxidants

Chevalier, A., Khdour, O., Schmierer, M., Bandyopadhyay, I. & Hecht, S., Mar 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 5, p. 1703-1716 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids

Bai, X., Talukder, P., Daskalova, S. M., Roy, B., Chen, S., Li, Z., Dedkova, L. & Hecht, S., Apr 5 2017, In : Journal of the American Chemical Society. 139, 13, p. 4611-4614 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB

Chen, S., Maini, R., Bai, X., Nangreave, R. C., Dedkova, L. & Hecht, S., Oct 11 2017, In : Journal of the American Chemical Society. 139, 40, p. 14098-14108 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2018

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P., Hecht, S. & Khdour, O., Oct 1 2018, In : Data in Brief. 20, p. 1105-1114 10 p.

Research output: Contribution to journalArticle

2016

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting

Chevalier, A., Zhang, Y., Khdour, O., Kaye, J. B. & Hecht, S., Sep 21 2016, In : Journal of the American Chemical Society. 138, 37, p. 12009-12012 4 p.

Research output: Contribution to journalArticle

75 Scopus citations
2018

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Mastroeni, D., Nolz, J., Khdour, O., Sekar, S., Delvaux, E., Cuyugan, L., Liang, W. S., Hecht, S. & Coleman, P., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase β with Unnatural Lysine Analogues

Daskalova, S. M., Bhattacharya, C., Dedkova, L. & Hecht, S., Jan 24 2017, In : Biochemistry. 56, 3, p. 500-513 14 p.

Research output: Contribution to journalArticle

3 Scopus citations