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  • Michael Lynch
2017

Genome-wide biases in the rate and molecular spectrum of spontaneous mutations in vibrio cholerae and vibrio fischeri

Dillon, M. M., Sung, W., Sebra, R., Lynch, M. & Cooper, V. S., Jan 1 2017, In : Molecular Biology and Evolution. 34, 1, p. 93-109 17 p.

Research output: Contribution to journalArticle

29 Scopus citations
2016

Evolution of the insertion-deletion mutation rate across the tree of life

Sung, W., Ackerman, M. S., Dillon, M. M., Platt, T. G., Fuqua, C., Cooper, V. S. & Lynch, M., Jan 1 2016, In : G3: Genes, Genomes, Genetics. 6, 8, p. 2583-2591 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2018

Limited mutation-rate variation within the Paramecium aurelia species complex

Long, H., Doak, T. G. & Lynch, M., Jul 1 2018, In : G3: Genes, Genomes, Genetics. 8, 7, p. 2523-2526 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2020
2017

Estimating seven coefficients of pairwise relatedness using population-genomic data

Ackerman, M. S., Johri, P., Spitze, K., Xu, S., Doak, T. G., Young, K. & Lynch, M., May 2017, In : Genetics. 206, 1, p. 105-118 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Mutation and human exceptionalism: Our future genetic load

Lynch, M., Mar 2016, In : Genetics. 202, 3, p. 869-875 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Promoter architecture and sex-specific gene expression in Daphnia pulex

Raborn, R. T., Spitze, K., Brendel, V. P. & Lynch, M., Oct 2016, In : Genetics. 204, 2, p. 593-612 20 p.

Research output: Contribution to journalArticle

10 Scopus citations

High mutational rates of large-scale duplication and deletion in Daphnia pulex

Keith, N., Tucker, A. E., Jackson, C. E., Sung, W., Lledó, J. I. L., Schrider, D. R., Schaack, S., Dudycha, J. L., Ackerman, M., Younge, A. J., Shaw, J. R. & Lynch, M., Jan 2016, In : Genome research. 26, 1, p. 60-69 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2017

Catalytic properties of RNA polymerases IV and V: Accuracy, nucleotide incorporation and rNTP/dNTP discrimination

Marasco, M., Li, W., Lynch, M. & Pikaard, C. S., Jan 1 2017, In : Nucleic Acids Research. 45, 19, p. 11315-11326 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Low base-substitution mutation rate in the germline genome of the ciliate tetrahymena thermophila

Long, H., Winter, D. J., Chang, A. Y. C., Sung, W., Wu, S. H., Balboa, M., Azevedo, R. B. R., Cartwright, R., Lynch, M. & Zufall, R. A., 2016, In : Genome Biology and Evolution. 8, 12, p. 3629-3639 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Periodic variation of mutation rates in bacterial genomes associated with replication timing

Dillon, M. M., Sung, W., Lynch, M. & Cooper, V. S., Jul 1 2018, In : mBio. 9, 4, e01371-18.

Research output: Contribution to journalArticle

8 Scopus citations
2020

The Limits to Estimating Population-Genetic Parameters with Temporal Data

Lynch, M. & Ho, W. C., Apr 1 2020, In : Genome biology and evolution. 12, 4, p. 443-455 13 p.

Research output: Contribution to journalArticle

Open Access
2017

Genome-wide mutation rate response to pH change in the coral reef pathogen vibrio shilonii AK1

Strauss, C., Long, H., Patterson, C. E., Te, R. & Lynch, M., Jul 1 2017, In : mBio. 8, 4, e01021-17.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Addressing ecological effects of radiation on populations and ecosystems to improve protection of the environment against radiation: Agreed statements from a Consensus Symposium

Bréchignac, F., Oughton, D., Mays, C., Barnthouse, L., Beasley, J. C., Bonisoli-Alquati, A., Bradshaw, C., Brown, J., Dray, S., Geras'kin, S., Glenn, T., Higley, K., Ishida, K., Kapustka, L., Kautsky, U., Kuhne, W., Lynch, M., Mappes, T., Mihok, S., Møller, A. P. & 8 others, Mothersill, C., Mousseau, T. A., Otaki, J., Pryakhin, E., Rhodes, O. E., Salbu, B., Strand, P. & Tsukada, H., Jul 1 2016, In : Journal of Environmental Radioactivity. 158-159, p. 21-29 9 p.

Research output: Contribution to journalReview article

38 Scopus citations
2017

The landscape of transcription errors in eukaryotic cells

Gout, J. F., Li, W., Fritsch, C., Li, A., Haroon, S., Singh, L., Hua, D., Fazelinia, H., Smith, Z., Seeholzer, S., Thomas, K., Lynch, M. & Vermulst, M., Oct 1 2017, In : Science advances. 3, 10, e1701484.

Research output: Contribution to journalArticle

24 Scopus citations
2019

The importance of the Neutral Theory in 1968 and 50 years on: A response to Kern and Hahn 2018

Jensen, J., Payseur, B. A., Stephan, W., Aquadro, C. F., Lynch, M., Charlesworth, D. & Charlesworth, B., Jan 2019, In : Evolution. 73, 1, p. 111-114 4 p.

Research output: Contribution to journalComment/debate

15 Scopus citations

Genetic control of male production in Daphnia pulex

Ye, Z., Molinier, C., Zhao, C., Haag, C. R. & Lynch, M., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15602-15609 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

A maximum-likelihood approach to estimating the insertion frequencies of transposable elements from population sequencing data

Jiang, X., Tang, H., Mohammed Ismail, W. & Lynch, M., Jan 1 2018, In : Molecular biology and evolution. 35, 10, p. 2560-2571 12 p.

Research output: Contribution to journalArticle

Specificity of the DNA Mismatch Repair System (MMR) and Mutagenesis Bias in Bacteria

Long, H., Miller, S. F., Williams, E. & Lynch, M., Oct 1 2018, In : Molecular Biology and Evolution. 35, 10, p. 2414-2421 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Genotype calling from population-genomic sequencing data

Maruki, T. & Lynch, M., May 1 2017, In : G3: Genes, Genomes, Genetics. 7, 5, p. 1393-1404 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2018

Escherichia coli cultures maintain stable subpopulation structure during long-term evolution

Behringer, M. G., Choi, B. I., Miller, S. F., Doak, T. G., Karty, J. A., Guo, W. & Lynch, M., May 15 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 20, p. E4642-E4650

Research output: Contribution to journalArticle

10 Scopus citations
2019

Evolution of protein interfaces in multimers and fibrils

Zabel, W. J., Hagner, K. P., Livesey, B. J., Marsh, J. A., Setayeshgar, S., Lynch, M. & Higgs, P. G., Jun 14 2019, In : Journal of Chemical Physics. 150, 22, 225102.

Research output: Contribution to journalArticle

Open Access
2017

Population Genomics of Paramecium Species

Johri, P., Krenek, S., Marinov, G. K., Doak, T. G., Berendonk, T. U. & Lynch, M., May 1 2017, In : Molecular Biology and Evolution. 34, 5, p. 1194-1216 23 p.

Research output: Contribution to journalArticle

9 Scopus citations

The glyphosate-based herbicide roundup does not elevate genome-wide mutagenesis of Escherichia coli

Tincher, C., Long, H., Behringer, M., Walker, N. & Lynch, M., Oct 1 2017, In : G3: Genes, Genomes, Genetics. 7, 10, p. 3331-3335 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mutation, eugenics, and the boundaries of science

Lynch, M., Oct 2016, In : Genetics. 204, 2, p. 825-827 3 p.

Research output: Contribution to journalLetter

3 Scopus citations
2018

An Escherichia coli nitrogen starvation response is important for mutualistic coexistence with Rhodopseudomonas palustris

McCully, A. L., Behringer, M. G., Gliessman, J. R., Pilipenko, E. V., Mazny, J. L., Lynch, M., Drummond, D. A. & McKinlay, J. B., Jul 1 2018, In : Applied and environmental microbiology. 84, 14, e00404-18.

Research output: Contribution to journalArticle

An unbiased genome-wide view of the mutation rate and spectrum of the endosymbiotic bacterium teredinibacter turnerae

Senra, M. V. X., Sung, W., Ackerman, M., Miller, S. F., Lynch, M. & Soares, C. A. G., Jan 1 2018, In : Genome Biology and Evolution. 10, 3, p. 723-730 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Similar mutation rates buthighlydiverse mutation spectra in ascomycete and basidiomycete yeasts

Long, H., Behringer, M. G., Williams, E., Te, R. & Lynch, M., Jan 1 2016, In : Genome Biology and Evolution. 8, 12, p. 3815-3821 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Genetic drift, selection and the evolution of the mutation rate

Lynch, M., Ackerman, M. S., Gout, J. F., Long, H., Sung, W., Thomas, W. K. & Foster, P. L., Oct 14 2016, In : Nature Reviews Genetics. 17, 11, p. 704-714 11 p.

Research output: Contribution to journalReview article

155 Scopus citations
2017

Population genomics of Daphnia pulex

Lynch, M., Gutenkunst, R., Ackerman, M., Spitze, K., Ye, Z., Maruki, T. & Jia, Z., May 2017, In : Genetics. 206, 1, p. 315-332 18 p.

Research output: Contribution to journalArticle

17 Scopus citations

Early stages of functional diversification in the Rab GTPase gene family revealed by genomic and localization studies in Paramecium species

Bright, L. J., Gout, J. F. & Lynch, M., Apr 15 2017, In : Molecular biology of the cell. 28, 8, p. 1101-1110 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2020

Universally high transcript error rates in bacteria

Li, W. & Lynch, M., May 2020, In : eLife. 9, p. 1-15 15 p., e54898.

Research output: Contribution to journalArticle

Open Access
2017

Membranes, energetics, and evolution across the prokaryote-eukaryote divide

Lynch, M. & Marinov, G. K., Mar 16 2017, In : eLife. 6, e20437.

Research output: Contribution to journalArticle

20 Scopus citations

Spontaneous mutations of a model heterotrophic marine bacterium

Sun, Y., Powell, K. E., Sung, W., Lynch, M., Moran, M. A. & Luo, H., Jul 1 2017, In : ISME Journal. 11, 7, p. 1713-1718 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2018

Stochastic protein multimerization, activity, and fitness

Hagner, K., Setayeshgar, S. & Lynch, M., Dec 7 2018, In : Physical Review E. 98, 6, 062401.

Research output: Contribution to journalArticle

3 Scopus citations
2020

Inference of historical population-size changes with allele-frequency data

Lynch, M., Haubold, B., Pfaffelhuber, P. & Maruki, T., Jan 1 2020, In : G3: Genes, Genomes, Genetics. 10, 1, p. 211-223 13 p.

Research output: Contribution to journalArticle

Open Access
2016

Diversity and divergence of dinoflagellate histone proteins

Marinov, G. K. & Lynch, M., 2016, In : G3: Genes, Genomes, Genetics. 6, 2, p. 397-422 26 p.

Research output: Contribution to journalArticle

13 Scopus citations

Antibiotic treatment enhances the genome-wide mutation rate of target cells

Long, H., Miller, S. F., Strauss, C., Zhao, C., Cheng, L., Ye, Z., Griffin, K., Te, R., Lee, H., Chen, C. C. & Lynch, M., May 3 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 18, p. E2498-E2505

Research output: Contribution to journalArticle

51 Scopus citations

The rate and spectrum of spontaneous mutations in Mycobacterium smegmatis, a bacterium naturally devoid of the postreplicative mismatch repair pathway

Kucukyildirim, S., Long, H., Sung, W., Miller, S. F., Doak, T. G. & Lynch, M., Jul 1 2016, In : G3: Genes, Genomes, Genetics. 6, 7, p. 2157-2163 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2017

A new reference genome assembly for the microcrustacean Daphnia pulex

Ye, Z., Xu, S., Spitze, K., Asselman, J., Jiang, X., Ackerman, M. S., Lopez, J., Harker, B., Raborn, R. T., Thomas, W. K., Ramsdell, J., Pfrender, M. E. & Lynch, M., May 1 2017, In : G3: Genes, Genomes, Genetics. 7, 5, p. 1405-1416 12 p.

Research output: Contribution to journalArticle

30 Scopus citations
2020

A Theoretical Framework for Evolutionary Cell Biology

Lynch, M. & Trickovic, B., Mar 27 2020, In : Journal of molecular biology. 432, 7, p. 1861-1879 19 p.

Research output: Contribution to journalReview article

Considering mutational meltdown as a potential SARS-CoV-2 treatment strategy

Jensen, J. D. & Lynch, M., May 1 2020, In : Heredity. 124, 5, p. 619-620 2 p.

Research output: Contribution to journalComment/debate

Open Access
2019

Population Genetics of Paramecium Mitochondrial Genomes: Recombination, Mutation Spectrum, and Efficacy of Selection

Johri, P., Marinov, G. K., Doak, T. G. & Lynch, M., May 1 2019, In : Genome biology and evolution. 11, 5, p. 1398-1416 19 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2016

Conservation and divergence of the histone code in nucleomorphs

Marinov, G. K. & Lynch, M., Apr 5 2016, In : Biology Direct. 11, 1, 18.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Insertion polymorphisms of mobile genetic elements in sexual and asexual populations of daphnia pulex

Jiang, X., Tang, H., Ye, Z. & Lynch, M., 2017, In : Genome biology and evolution. 9, 2, p. 362-374 13 p.

Research output: Contribution to journalArticle

7 Scopus citations
2018

Response to Martin and colleagues: Mitochondria do not boost the bioenergetic capacity of eukaryotic cells

Lynch, M. & Marinov, G. K., Nov 29 2018, In : Biology Direct. 13, 1, 26.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Joseph Shapiro, an Icon of Applied Limnology

Lynch, M., Feb 1 2019, In : Limnology and Oceanography Bulletin. 28, 1, p. 35-37 3 p.

Research output: Contribution to journalComment/debate

2018

Phylogenetic divergence of cell biological features

Lynch, M., Jun 21 2018, In : eLife. 7, e34820.

Research output: Contribution to journalArticle

3 Scopus citations

Erratum: Correction: Membranes, Energetics, and Evolution Across the Prokaryote-Eukaryote Divide (eLife (2017) 6 PII: e35006)

Lynch, M. & Marinov, G., Jul 5 2018, In : eLife. 7

Research output: Contribution to journalComment/debate

Open Access