9.14 - Making New Materials from Viral Capsids

N. Stephanopoulos; M. B. Francis

doi:10.1016/B978-0-444-53349-4.00221-1

9.14 - Making New Materials from Viral Capsids

N. Stephanopoulos, M. B. Francis

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

The protein capsids of viruses represent a fascinating class of regular geometric objects formed through efficient self-assembly processes. By capitalizing on the ability of these multivalent structures to arrange large numbers of synthetic functional groups, viral capsids have now found use in three major areas of materials science: (1) as templates for the growth and/or positioning of inorganic nanoparticles; (2) as carriers for use in biomedical imaging and drug delivery; and (3) as scaffolds for photoactive and chemically catalytic groups. This chapter surveys the recent progress in these fields and examines the various chemical techniques that have been used to add new chemical functionality to these structures.

Original language	English (US)
Title of host publication	Polymer Science
Subtitle of host publication	a Comprehensive Reference: Volume 1-10
Publisher	Elsevier
Pages	247-266
Number of pages	20
Volume	1-10
ISBN (Electronic)	9780080878621
DOIs	https://doi.org/10.1016/B978-0-444-53349-4.00221-1
State	Published - Jan 1 2012
Externally published	Yes

Keywords

Bioconjugation
Capsids
Catalysis
Diagnostic imaging
Drug delivery
Encapsulation
Genetic engineering
Light harvesting
Nanoparticles
Photosynthesis
Proteins
Self-assembly
Viruses

ASJC Scopus subject areas

General Engineering
General Materials Science
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/B978-0-444-53349-4.00221-1

Cite this

@inbook{0724877fea6c444d989bc3b691ed87be,

title = "9.14 - Making New Materials from Viral Capsids",

abstract = "The protein capsids of viruses represent a fascinating class of regular geometric objects formed through efficient self-assembly processes. By capitalizing on the ability of these multivalent structures to arrange large numbers of synthetic functional groups, viral capsids have now found use in three major areas of materials science: (1) as templates for the growth and/or positioning of inorganic nanoparticles; (2) as carriers for use in biomedical imaging and drug delivery; and (3) as scaffolds for photoactive and chemically catalytic groups. This chapter surveys the recent progress in these fields and examines the various chemical techniques that have been used to add new chemical functionality to these structures.",

keywords = "Bioconjugation, Capsids, Catalysis, Diagnostic imaging, Drug delivery, Encapsulation, Genetic engineering, Light harvesting, Nanoparticles, Photosynthesis, Proteins, Self-assembly, Viruses",

author = "N. Stephanopoulos and Francis, {M. B.}",

note = "Funding Information: Our efforts to develop new bioconjugation strategies, capsid-based delivery agents, and protein–polymer hybrid materials have been generously supported by the NIH (GM072700), the DOD Breast Cancer Research Program (BC061995), and the NSF (0449772). Funding for our work on viral capsid-based light-harvesting systems, as well as fellowship support for N. Stephanopoulos while writing this manuscript, was provided by the Director, Office of Science, Materials Sciences and Engineering Division, of the US Department of Energy under Contract No. DE-AC02-05CH11231. Publisher Copyright: {\textcopyright} 2012 Elsevier B.V. All rights reserved.",

year = "2012",

month = jan,

day = "1",

doi = "10.1016/B978-0-444-53349-4.00221-1",

language = "English (US)",

volume = "1-10",

pages = "247--266",

booktitle = "Polymer Science",

publisher = "Elsevier",

}

TY - CHAP

T1 - 9.14 - Making New Materials from Viral Capsids

AU - Stephanopoulos, N.

AU - Francis, M. B.

N1 - Funding Information: Our efforts to develop new bioconjugation strategies, capsid-based delivery agents, and protein–polymer hybrid materials have been generously supported by the NIH (GM072700), the DOD Breast Cancer Research Program (BC061995), and the NSF (0449772). Funding for our work on viral capsid-based light-harvesting systems, as well as fellowship support for N. Stephanopoulos while writing this manuscript, was provided by the Director, Office of Science, Materials Sciences and Engineering Division, of the US Department of Energy under Contract No. DE-AC02-05CH11231. Publisher Copyright: © 2012 Elsevier B.V. All rights reserved.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - The protein capsids of viruses represent a fascinating class of regular geometric objects formed through efficient self-assembly processes. By capitalizing on the ability of these multivalent structures to arrange large numbers of synthetic functional groups, viral capsids have now found use in three major areas of materials science: (1) as templates for the growth and/or positioning of inorganic nanoparticles; (2) as carriers for use in biomedical imaging and drug delivery; and (3) as scaffolds for photoactive and chemically catalytic groups. This chapter surveys the recent progress in these fields and examines the various chemical techniques that have been used to add new chemical functionality to these structures.

AB - The protein capsids of viruses represent a fascinating class of regular geometric objects formed through efficient self-assembly processes. By capitalizing on the ability of these multivalent structures to arrange large numbers of synthetic functional groups, viral capsids have now found use in three major areas of materials science: (1) as templates for the growth and/or positioning of inorganic nanoparticles; (2) as carriers for use in biomedical imaging and drug delivery; and (3) as scaffolds for photoactive and chemically catalytic groups. This chapter surveys the recent progress in these fields and examines the various chemical techniques that have been used to add new chemical functionality to these structures.

KW - Bioconjugation

KW - Capsids

KW - Catalysis

KW - Diagnostic imaging

KW - Drug delivery

KW - Encapsulation

KW - Genetic engineering

KW - Light harvesting

KW - Nanoparticles

KW - Photosynthesis

KW - Proteins

KW - Self-assembly

KW - Viruses

UR - http://www.scopus.com/inward/record.url?scp=84884948047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884948047&partnerID=8YFLogxK

U2 - 10.1016/B978-0-444-53349-4.00221-1

DO - 10.1016/B978-0-444-53349-4.00221-1

M3 - Chapter

AN - SCOPUS:84884948047

VL - 1-10

SP - 247

EP - 266

BT - Polymer Science

PB - Elsevier

ER -

9.14 - Making New Materials from Viral Capsids

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this