9-Aminoacridine mutagenesis of bacteriophage T4 intracellular DNA

S. Altman, V. Warner

Research output: Contribution to journalArticle

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Abstract

Most of the intracellular T4 DNA made in the presence of 9-aminoacridine is of lower molecular weight than mature T4 DNA and does not get packaged into phage particles. Using a T4 DNA transformation assay, we have examined this intracellular T4 DNA for its content of 9-aminoacridine-induced revertants of certain rII gene frameshift mutations. The proportion of acridine-induced revertants in the intracellular DNA population is close to that found in the phage progeny made in the presence of 9-aminoacridine. Thus, the generation of low molecular weight T4 DNA in the presence of 9-aminoacridine is not, in itself, also a mutagenic process.

Original languageEnglish (US)
Pages (from-to)333-343
Number of pages11
JournalMGG Molecular & General Genetics
Volume138
Issue number4
DOIs
StatePublished - Dec 1 1975

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ASJC Scopus subject areas

  • Genetics

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