5-Propynyluracil·diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA

John C. Chaput; Surajit Sinha; Christopher Switzer

doi:10.1039/b204535d

5-Propynyluracil·diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA

John C. Chaput, Surajit Sinha, Christopher Switzer

CLAS-NS: Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The Up·D base-pair (5-propynyl uracil·diaminopurine) is found to be more effective at non-enzymatic transcription than the corresponding natural T·A pair; under non-enzymatic reaction conditions where the natural T·A base-pair fails, a DNA template bearing Up efficiently directs the incorporation of D into a product RNA strand.

Original language	English (US)
Pages (from-to)	1568-1569
Number of pages	2
Journal	Chemical Communications
Volume	2
Issue number	15
DOIs	https://doi.org/10.1039/b204535d
State	Published - Jan 1 2002

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "The Up·D base-pair (5-propynyl uracil·diaminopurine) is found to be more effective at non-enzymatic transcription than the corresponding natural T·A pair; under non-enzymatic reaction conditions where the natural T·A base-pair fails, a DNA template bearing Up efficiently directs the incorporation of D into a product RNA strand.",

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