(2S,3S,4R)-4-Amino-3-hydroxy-2-methylvalerate. Synthesis of an Amino Acid Constituent of Bleomycin from L-Rhamnose

Tadaaki Ohgi, Sidney M. Hecht

Research output: Contribution to journalLetter

26 Scopus citations

Abstract

(2S,3S,4R)-4-Amino-3-hydroxy-2-methylvalerate, an amino acid constituent of the antitumor antibiotic bleomycin, has been prepared from L-rhamnose. This approach to a chiral 3-hydroxy-2-methylcarboxylate constitutes an alternative to the stereoselective aldol condensation.

Original languageEnglish (US)
Pages (from-to)1232-1234
Number of pages3
JournalJournal of Organic Chemistry
Volume46
Issue number6
DOIs
StatePublished - Mar 1981
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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