1,8-Naphthyridine-2,7-diamine: A potential universal reader of Watson-Crick base pairs for DNA sequencing by electron tunneling

Feng Liang, Stuart Lindsay, Peiming Zhang

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

With the aid of Density Functional Theory (DFT), we designed 1,8-naphthyridine-2,7-diamine as a recognition molecule to read DNA base pairs for genomic sequencing by electron tunneling. NMR studies show that it can form stable triplets with both A:T and G:C base pairs through hydrogen bonding. Our results suggest that the naphthyridine molecule should be able to function as a universal base pair reader in a tunneling gap, generating distinguishable signatures under electrical bias for each of DNA base pairs.

Original languageEnglish (US)
Pages (from-to)8654-8659
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number43
DOIs
StatePublished - Nov 21 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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