15 Citations (Scopus)

Abstract

With the aid of Density Functional Theory (DFT), we designed 1,8-naphthyridine-2,7-diamine as a recognition molecule to read DNA base pairs for genomic sequencing by electron tunneling. NMR studies show that it can form stable triplets with both A:T and G:C base pairs through hydrogen bonding. Our results suggest that the naphthyridine molecule should be able to function as a universal base pair reader in a tunneling gap, generating distinguishable signatures under electrical bias for each of DNA base pairs.

Original languageEnglish (US)
Pages (from-to)8654-8659
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number43
DOIs
StatePublished - Nov 21 2012

Fingerprint

Electron tunneling
sequencing
readers
diamines
electron tunneling
DNA Sequence Analysis
Base Pairing
deoxyribonucleic acid
Naphthyridines
Electrons
Molecules
DNA
Density functional theory
Hydrogen bonds
Nuclear magnetic resonance
Hydrogen Bonding
molecules
signatures
density functional theory
nuclear magnetic resonance

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

1,8-Naphthyridine-2,7-diamine : A potential universal reader of Watson-Crick base pairs for DNA sequencing by electron tunneling. / Liang, Feng; Lindsay, Stuart; Zhang, Peiming.

In: Organic and Biomolecular Chemistry, Vol. 10, No. 43, 21.11.2012, p. 8654-8659.

Research output: Contribution to journalArticle

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AB - With the aid of Density Functional Theory (DFT), we designed 1,8-naphthyridine-2,7-diamine as a recognition molecule to read DNA base pairs for genomic sequencing by electron tunneling. NMR studies show that it can form stable triplets with both A:T and G:C base pairs through hydrogen bonding. Our results suggest that the naphthyridine molecule should be able to function as a universal base pair reader in a tunneling gap, generating distinguishable signatures under electrical bias for each of DNA base pairs.

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