Abstract
With the aid of Density Functional Theory (DFT), we designed 1,8-naphthyridine-2,7-diamine as a recognition molecule to read DNA base pairs for genomic sequencing by electron tunneling. NMR studies show that it can form stable triplets with both A:T and G:C base pairs through hydrogen bonding. Our results suggest that the naphthyridine molecule should be able to function as a universal base pair reader in a tunneling gap, generating distinguishable signatures under electrical bias for each of DNA base pairs.
Original language | English (US) |
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Pages (from-to) | 8654-8659 |
Number of pages | 6 |
Journal | Organic and Biomolecular Chemistry |
Volume | 10 |
Issue number | 43 |
DOIs | |
State | Published - Nov 21 2012 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry