Variations in Hormones during Menopause: Effects on Cognitive and Brain Aging

Project: Research project

Project Details

Description

In this renewal, we hypothesize that type of menopause and associated hormone changes relate to cognitive responsiveness to hormone therapy (HT). The initial grant used rats to assess variations in HTs with surgical menopause (Ovx), and transitional menopause using 4-vinylcyclohexene diepoxide (VCD). VCD-treated rats undergo ovarian failure; follicles and estrogens deplete, androgens become unopposed, and gonadotropins increase, a profile resembling transitionally menopausal women. Despite insight the Ovx model yields, surgical menopause only models
StatusFinished
Effective start/end date9/1/135/31/16

Funding

  • HHS: National Institutes of Health (NIH): $918,847.00

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