Variations in Hormones During Menopause: Effects on Cognitive and Brain Aging

Project: Research project

Description

In this renewal, we hypothesize that type of menopause and associated hormone changes relate to cognitive responsiveness to hormone therapy (HT). The initial grant used rats to assess variations in HTs with surgical menopause (Ovx), and transitional menopause using 4-vinylcyclohexene diepoxide (VCD). VCD-treated rats undergo ovarian failure; follicles and estrogens deplete, androgens become unopposed, and gonadotropins increase, a profile resembling transitionally menopausal women. Despite insight the Ovx model yields, surgical menopause only models
StatusActive
Effective start/end date6/1/165/31/23

Funding

  • HHS: National Institutes of Health (NIH): $1,397,885.00

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Menopause
Hormones
Brain
Anatomic Models
Organized Financing
Gonadotropins
Androgens
Estrogens
Cognitive Aging
4-vinyl-1-cyclohexene dioxide
Therapeutics