While mammals have only limited ability for regeneration, lizards can regrow their entire tail after loss, including the ependymal cells at the core of their spinal cord that help to guide axon regrowth. Lizards and mammals are both amniote vertebrates, and we hypothesize that spinal cord regeneration involves activation of conserved genetic pathways that could potentially be activated to stimulate human ependymal proliferation. With the recent release of genome sequence for the lizard, Anolis carolinensis, RNA-Seq cutting-edge technology is ideally suited for identifying all genes in spinal cord regeneration. We propose carrying out RNA Seq and functional anatomical analysis of the regenerating spinal cord of Anolis carolinensis. We are currently working with this lizard and are sharing data with the research community through our www.anolisgenome.org database. These studies have great potential for direct translation into future regenerative medical therapies for spinal cord injury.
|Effective start/end date||7/1/11 → 6/30/13|
- Arizona Biomedical Research Commission: $225,000.00