Time restricted feeding and breast Cancer

Project: Research project

Project Details

Description

I will devote 2.3% effort each year to the project during approximate two years remaining in the on-going project period (1 year, 10.5 months) that constitutes this subcontract. I have been a co-investigator on the parent R01 project for this subcontract since its inception, prior to my hire at ASU. I have extensive experience in genetic mouse models of insulin resistance, inflammation, and cancer. I am currently contributing to the assessment of biomarkers and insulin resistance in the animal studies conducted at the UCSD parent site. The major goal of this project is to investigate the mechanisms by which obesity increases risk of breast cancer and how that risk is reduced using time-restricted feeding a postmenopausal obese mouse model that I co-created with my UCSD colleagues prior to my ASU hire. Time-restricted feeding, where feeding is allowed only in the active time of day, nighttime for mice and daytime for humans, is highly translational from rodents to humans. I have several publications and an active research program focused on health benefits of time-restricted feeding and circadian alignment of food intake in humans, which are highly related to this projects mouse studies. I will continue to coordinate biomarker assessments in the mouse studies and align these with my on-going clinical projects, using the mouse study findings to optimize and prioritize biomarker selection in my clinical studies.

I will also continue to contribute to statistical analyses and manuscript preparations for the project. I have extensive leadership and administrative experience both in research projects, academia, and on community boards (see Biosketch). I will attend regular team meetings, as needed, with the UCSD team remotely by Zoom and travel to San Diego 1X/year for in-person meetings. I have collaborated with Drs. Webster and Ellies (PI and co-investigator, respectively, on the R01 parent subcontracting project) for many years. We have a strong collaborative dynamic and have published several papers together in mouse models of cancer.
StatusActive
Effective start/end date5/16/193/31/21

Funding

  • HHS: National Institutes of Health (NIH): $17,145.00

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