The Role of X Chromosome Inactivation in Breast Cancer

The Role of X Chromosome Inactivation in Breast Cancer X inactivation and breast cancer We will assess gene content and expression of X-linked genes and regulatory elements within 1098 samples from breast cancer patients in The Cancer Genome Atlas (TCGA). To accomplish this we will identify differentially expressed X-linked genes between breast cancer subtypes, assess the escape status of each X-linked gene, and compare shared and unique variation in gene expression across breast cancer subtypes. Of significant interest will be genes including X-linked immune-related and regulatory elements associated with gene dosage and X-chromosome inactivation. These data will be used to test hypotheses regarding the role of these genes and regulatory elements in different subtypes of breast cancer (e.g. HER2+, triple negative).