The role of collagen and its signaling mechanisms in glioma progression and invasion The role of collagen and its signaling mechanisms in glioma progression and invasion For this application, I will participate in developing image processing algorithms for the analysis of cell motility data. Specifically, I will perform the detailed quantification of cells present in the ex vivo experiments, studying the dynamics of intratumoral collective motion and the consequences for tumor growth. Although there are already several tools available (e.g. ImageJ), the rise of machine learning in medical imaging has seen the rapid development of new methods to solve biomedical problems such as the U-Net architecture for image segmentation. I will also perform statistical analysis to estimate glioma cell correlations of directionality, speed, and cellular density. These studies will help us understand the mechanisms underlying oncostream dynamics and collective motion from a mechanical perspective. Together with the rest of the biochemical and molecular experiments described in the main body of the application, these studies will be crucial in placing our work on a strong quantitative foundation.
|Effective start/end date||12/15/21 → 11/30/26|
- HHS: National Institutes of Health (NIH): $155,728.00
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