The influence of injury severity on endogenous regeneration after traumatic brain injury

Project: Research project

Project Details

Description

The influence of injury severity on endogenous regeneration after traumatic brain injury The influence of injury severity on endogenous regeneration after traumatic brain injury Project Summary Traumatic brain injury (TBI) is commonly thought of as a single incident injury; however, clinical and basic science research over the past several decades has demonstrated that TBI patients experience chronic neurodegeneration and persistent neurological, vegetative, and psychiatric symptoms for many months to years after injury. Moreover, recent studies have related markers of neurodegeneration and an increased risk of dementia and death related to progressive cognitive impairment in retired professional football players and military personnel who sustained TBI related to blast injuries. The most concerning aspect of this clinical problem is that no treatment is currently available for TBI patients of any injury severity. Therefore, our objective with this proposal is to evaluate injury initiated signaling paradigms that stimulate recruitment of endogenous neural stem cells after traumatic brain injury. More specifically, we will correlate signaling molecules and cascades with injury severity to compare and contrast mild concussive injuries versus moderate/severe injury levels. Collectively, upon completion of this study we will have identified candidate signaling molecules to investigate as the foundation for future therapeutic approaches to markedly enhance inherent endogenous regeneration after traumatic brain injury of any level of severity.
StatusFinished
Effective start/end date1/1/1312/31/13

Funding

  • Mayo Clinic Arizona: $40,000.00

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.