The Effects of Re-Engineered Carbohydrates on Metabolic Syndrome (ASUF 30006283)

Project: Research project

Project Details


The Effects of Re-Engineered Carbohydrates on Metabolic Syndrome (ASUF 30006283) The Effects of Re-Engineered Carbohydrates on Metabolic Syndrome The Effects of Re-Engineered Carbohydrates on Metabolic Syndrome The ever-increasing prevalence of metabolic syndrome is associated with many metabolic disturbances, which can be attributed to chronic, low-level inflammation. Chronic tissue and systemic inflammation is a key component of insulin resistance, which is co-incident with the metabolic syndrome, type 2 diabetes and cardiovascular disease. Greater insight is needed about the mechanisms of systemic inflammation, which underlie insulin resistance, the metabolic syndrome, and other diseases, and how anti-inflammatory agents can be used to mitigate disease. Development and implementation of pharmacological approaches to reducing inflammation are expensive and often confounded by undesirable, sometimes dangerous, side effects. In contrast, dietary modification approaches can offer safe and effective ways to reduce inflammation and improve insulin sensitivity. The feasibility of a novel, three-pronged dietary intervention will be tested for improving clinical features of the metabolic syndrome and reducing inflammation in subjects with the metabolic syndrome. The foundational feature of the intervention is a diet of protein-rich, low glycemic index foods enriched with anti-inflammatory chocolate polyphenols. The glycemic and macronutrient properties of these products will dramatically reduce the intake of pro-inflammatory omega-6 fatty acids and help reduce insulin resistance. The other features of the intervention are additional supplementation with antiinflammatory nutrients consisting of (1) highly purified omega-3 fatty acids and (2) purified polyphenol extract rich in delphinidins extracted from the maqui berry. Background Seventy nine million Americans have metabolic syndrome, which can be considered prediabetes. 1 Metabolic syndrome is characterized by an array of metabolic dysfunction including obesity, insulin resistance, hyperlipidemia, and low-level chronic inflammation.2 The proposed pilot study will test the hypothesis that dietary modulation of low-level chronic inflammation and other metabolic syndrome-associated abnormalities can be synergistically achieved by implementing a multi-pronged dietary intervention strategy that utilizes several patented food technologies. The proposed studies will contribute new insights about the feasibility of a novel dietary intervention and direct and promote safer, non-pharmacological therapeutic strategies for the clinical care of patients with the metabolic syndrome. Investigator Backgrounds Dr. Barry Sears is the President of the non-profit . He has published more than 30 scientific articles. He has 13 U.S. Patents in the areas of drug delivery systems and dietary treatment of hyperinsulinemia, and cardiovascular disease. He has written 12 books on anti-inflammatory nutrition, including the New York Times #1 bestseller, The Zone. He is considered one of the leading authorities on diet-induced hormonal responses and their effects on inflammation. Mary Perry is the Clinical Trials Director of the . She is a registered dietician and has a Masters degree in nutrition. Previously, she was a research dietician at the Brighams and Womens Hospital. Dr. Carol Johnston is a Professor and Associate Director of the Nutrition department at Arizona State University School of Nutrition. Specific Aim The metabolic syndrome is associated with several patho-physiological abnormalities including chronic, low level chronic inflammation, dyslipidemia, and insulin resistance, which is the primary defect leading to type 2 diabetes. Several dietary interventions can affect insulin resistance. For example, diets rich in omega-6 fatty acids are pro-inflammatory and promote insulin resistance, whereas diets rich in omega-3 fatty acids are anti-inflammatory and improve insulin sensitivity. It is known that reducing the glycemic index of the diet, increasing the omega-3 fatty acids or polyphenol content of the diet results in reduc
Effective start/end date8/4/1412/31/16


  • Inflammation Research Foundation: $111,850.00


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