The Development of a Highly Efficient and User-Friendly Software System for Carotid Intima-Media Thickness Image Interpretation

Project: Research project

Project Details


The Development of a Highly Efficient and User-Friendly Software System for Carotid Intima-Media Thickness Image Interpretation The development of a highly efficient and user-friendly software system for carotid intima-media thickness image interpretation Cardiovascular disease (CVD) is the leading cause of mortality, but largely preventable, because effective interventions are availablethe key is to identify at risk individuals before adverse events. For stratifying individual CVD risk, carotid intima-media thickness (CIMT), a noninvasive ultrasound method, has proven to be valuable. It quantifies subclinical atherosclerosis, adds predictive value to traditional risk factors (e.g., the Framingham risk score), and has several advantages over CT coronary artery calcium score: safer (no radiation exposure), more sensitive in a young population, and more accessible to the primary care setting. However, a clinical challenge is that interpreting CIMT images is tedious, laborious, and time consuming with current software. In response to this challenge, we have developed an innovative software prototype, which is highly efficient, user-friendly, and shows strong intra- and inter-observer agreements in our preliminary evaluation. We are seeking financial support to translate this novel technology into routine clinical practice with three specific aims: (1) enhancing our software with additional capabilities for routine clinical use, (2) validating our software with a larger number of clinical cases, and (3) establishing industrial partnerships for commercialization and regulatory approvals. Naturally, the expected outcome from this project is a well-developed, thoroughly validated, efficient and user-friendly software system ready for commercialization. We expect a high demand for this system, because it not only reduces interpretation time, but also increases interpretation quality, thus saving cost, reducing turnaround time, improving patient care, and potentially increasing outpatient practice revenues. To commercialize and market our system, Mayo Clinic Ventures has kindly offered help to explore the potential to found a company and establish formal partnerships with GE, Siemens, Philips, and Radnostics (a diagnostics company based in New York City), etc. Cardiovascular Diagnostic Services, based in South Carolina, has a desire to be our first
Effective start/end date7/1/126/30/15


  • Mayo Clinic Arizona: $232,199.00


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