Synthesis characterization and properties of fast acting amorphous drugs

Project: Research project

Description

Arizona State University Statement of work 1.0 Background This position relates to the Directors Competitive LDRD (2011-012-N0 9146) Synthesis, Characterization and Properties of Fast Acting Amorphous Drugs. A graduate student from the Department of Chemistry& Biochemistry at Arizona State University will be hired part-time to perform high energy experiments on 11-ID-C at the Advanced photon Source and analyze the collected x-ray data from amorphous pharmaceutical drugs using novel processing techniques. They will also develop a software program to interpret the analyzed x-ray data to obtain molecular structure information. 2.0 Scope The hire is designed to help analyze x-ray data from pharmaceutical drugs samples obtained from innovative experiments at the Advanced Photon Source and provide a computer code for in-depth structural interpretation of the results. 3.0 Objectives The goals are to perform and analyze high energy x-ray experiments on a series of drugs and drug-polymer mixtures amorphized using an acoustic levitation process developed by physicists at Argonne. The development of a computer code is needed to interpret the x-ray scattering pattern obtained from the disordered structures. 4.0 Tasks Help develop the containerless materials-processing techniques at Argonne and help perform and analyze x-ray experiments at sector 11 of the APS. The writing, testing and use of a computer code, to model the molecular shape of specific drugs based on the measured x-ray diffraction pattern from drug and drug-polymer mixtures.
StatusFinished
Effective start/end date1/11/139/30/13

Funding

  • US Department of Energy (DOE): $40,001.00

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drugs
synthesis
computer programs
x rays
acoustic levitation
biochemistry
polymers
photons
x ray scattering
students
x ray diffraction
molecular structure
sectors
diffraction patterns
chemistry
energy