Sleep-Related Determinants of Stroke A Case-Sibling Study

Project: Research project

Project Details


Sleep-Related Determinants of Stroke A Case-Sibling Study Sleep-Related Determinants of Stroke: A Case-Sibling Study Stroke is the second leading cause of death worldwide. Traditional stroke risk factors explain about half of the risk for stroke. The remaining half may be partially explained by sleep duration and disturbances, which are prospectively related to incident stroke across multiple populations. Although these relationships have been identified, at present, essentially nothing is known regarding the modifiable, sleep-inhibiting behaviors that determine sleep duration and disruption; these are probable targets of stroke prevention. The study proposed here is intended to fill this void by determining the relation between sleep-inhibiting behaviors, self-reported sleep duration and disruption, and stroke amongst acute stroke inpatients. We will conduct a matched case-sibling design comparing 50 in-patients with acute ischemic stroke or transient ischemic attack to 50 age, sex, and ethnicity matched first and second-degree relatives of these cases. The participants will be assessed on their practice of modifiable, sleep-inhibiting behaviors and patterns as well as traditional stroke risk factors using an interviewer-delivered survey. The stroke unit at the Mayo Clinic in Phoenix, Arizona along with a team of three investigators at Arizona State University and two investigators at the Mayo Clinic will provide substantial support and environmental infrastructure to ensure the completion of this project.
Effective start/end date1/7/161/6/18


  • American Sleep Medicine Foundation: $20,000.00


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