Revolutionizing Utah Array using Nanotechnology to Enhance Efficacy and Longevity in Chronic Applications

Project: Research project

Project Details

Description

Revolutionizing Utah Array using Nanotechnology to Enhance Efficacy and Longevity in Chronic Applications Revolutionizing Utah Array using Nanotechnology to Enhance Efficacity and Longevity in Chronic Applications STATEMENT OF WORK Institution Arizona State University Title Revolutionizing Utah Array using Nanotechnology to Enhance Efficacy and Longevity in Chronic Applications Overview A hybrid UEA containing 50% standard Pt-electrodes and 50% nanotechnology enhanced Pt-electrodes macro will be chronically implanted in five cats. Neural recordings will be obtained daily for the first 30 days following implantation, and at least weekly for the subsequent two months. Electrophysiological recordings will be performed in the awake animal, and band-pass filtered at 0.3Hz 7.5 kHz and acquired at 30 kS/sec. In-vivo 1 kHz impedance measurements will be made during each recording session. Microstimulation will be performed while the feline is anesthetized in order to prevent spontaneous movement and allow fine-wire EMG recordings. Micro-stimulation and EMG recordings will be obtained weekly throughout the course of the study. Constant current stimulation will be varied from 50-200 A in intervals of 50 A. Trains of 25 biphasic pulses, at pulse durations of 0.2 ms, will be applied to all electrodes of the array in order to determine the amplitude of current required to evoke an EMG response. EMG responses will be recorded at 25 kS/sec using sterile, clinical fine-wire electrodes placed in the hind limb muscles. To determine the amplitude of the evoked response, the recorded EMG was filtered with a 100-1500 Hz, rectified and then convolved with a Gaussian window of standard deviation 10 ms. Stimulation current that evoked a significant EMG signal will be measured at pulse durations ranging from 0.15 to 0.8 ms. Other stimulation parameters will be held constant. Deliverables 1) Provide at least 2 months of recording data 2) Provide at least 3 months of stimulation data 3) Provide comparative electrophysiological analysis of surface modified and un-modified electrodes with regard to recording and stimulating characteristics. Metrics of Success 1) Strength-duration curves will be determined for a subset of the electrodes to serve as a comparison with other studies and provide a metric for optimizing stimulation in terms of safety and efficacy. 2) The neural data recording metrics, e.g. presence of isolated action potentials, correlation& coherence of local field potentials across electrodes will serve as functionality metrics for the arrays and neural tissue. 3) Additionally, the ability of stimulation to evoke EMG, and chronaxie and rheobase measurements, will serve as metrics of the physiological efficacy of stimulation. The physical parameters of the electrodes, the neural data recording metrics, and the stimulation efficacy metrics on the standard Pt-electrodes will be compared with the surface modified Pt-coated electrodes.
StatusFinished
Effective start/end date9/1/132/28/17

Funding

  • INDUSTRY: Domestic Company: $151,591.00

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