Redecorating the Neural Injury Landscape to Promote Regeneration

Project: Research project

Description

Abstract Traumatic brain injury (TBI) is the leading cause of injury related death in America. However, current clinical treatment modalities for TBI focus on minimizing the secondary symptoms and complications associated with TBI; however, no clinical treatments currently exist to address the underlying neuropathology for any level of TBI severity ranging from mild to severe. The long-term goal of the proposed research is to develop novel intervention strategies that directly tackle neurodegenerative cues and promote regeneration. This proposal is the first step in achieving our longterm goal whereby our primary objective is to mask and redecorate the neurodegenerative cues in the injury extracellular microenvironment by employing novel targeting probes generated from single-chain antibody fragments (nanobodies). Ultimately, our approach will contribute significant advances to improved understanding of how the extracellular microenvironment impacts neural regeneration after brain injury
StatusFinished
Effective start/end date10/23/1410/22/17

Funding

  • Arizona Biomedical Research Commission: $225,000.00

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Regeneration
Wounds and Injuries
Cues
Single-Domain Antibodies
Single-Chain Antibodies
Immunoglobulin Fragments
Masks
Brain Injuries
Traumatic Brain Injury
Research