Rapid disease diagnostics using photonic crystal enhanced antigen biomarker microarrays

Project: Research project

Description

Statement of Work Arizona State University Karen Anderson, MD, PhD In this study, Dr. Andersons laboratory will be responsible for preparation of HPV early proteins for microfluidic serology development. The proteins and sera will be provided by Dr. Anderson to the Cunningham laboratory. Specifically: 1) Protein preparation of HPV16 E1, E2, E4, E5, E6 and E7 recombinant proteins, including optimization of protein expression and purification. 2) Identification and selection of relevant sera for testing the microfluidic platform 3) IRB compliance, MTA compliance, and distribution of sera to U. Illinois for testing 4) Assessment of data, comparison to existing serologic platforms. 5) Correlation of the expression with clinical data 6) Participation in the conceptualization, planning, and data acquisition associated with all serology projects in the specific aims of this grant. 7) Supervision of the research technician (Ting Li) and the laboratory handling of tissue samples. 8) Regular conferences with Dr. Cunningham to assess progress, address problems, re-evaluate study goals, and review data.
StatusFinished
Effective start/end date6/1/145/31/19

Funding

  • HHS-NIH: National Institute of General Medical Sciences (NIGMS): $150,000.00

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Optics and Photonics
Microfluidics
Biomarkers
Serology
Antigens
Compliance
Pemetrexed
Tolnaftate
Proteins
Organized Financing
Research Ethics Committees
Serum
Recombinant Proteins
Blood Proteins
Research