Novel biomarkers for myocardial infarction based on protein heterogeneity Novel biomarkers for myocardial infarction based on protein heterogeneity We will conduct a case-control study nested in a cohort of patients presenting to the ED of the Singapore General Hospital with chest pain. The current department chest pain protocol requires that patients with chest pain with possible acute coronary syndrome but no diagnostic ECG changes will undergo our standard 8-hour observation protocol in the ECCU (Emergency Cardiac Care Unit) at the ED. They will be put on continuous ECG monitoring.12-lead ECG, and blood samples for Troponin will be drawn at 0, 2 and 7 hours. Patients who develop recurrent chest pain consistent with myocardial ischaemia, ST segment elevation or depression on 12 lead ECG indicating myocardial necrosis or have positive Troponin will be admitted to the Department of Cardiology. Patients with high or intermediate risk for coronary artery disease (CAD) as defined by the Agency for Healthcare Policy and Research Guidelines for unstable angina will be admitted to Department of Cardiology (National Heart Centre). Patients who are discharged from ED will be given an appointment to be reviewed 30 days later by a cardiologist at National Heart Centre. This assessment will also include a clinical determination of whether the patients symptoms are likely to be due to coronary artery disease.
|Effective start/end date||3/1/10 → 12/31/15|
- OTHER: Foreign Government: $45,069.00
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