Next Generation Precision Diagnostics for Brain Injury

Project: Research project

Project Details


Next Generation Precision Diagnostics for Brain Injury Next generation precision diagnostics for brain injury Over 1.7 million persons sustain a traumatic brain injury (TBI) in the U.S. alone. Current diagnostic techniques for TBI are excellent in detecting gross morphological alterations (i.e. hemorrhagic events, changes in water content, or the emergence of anisotropic tissue densities), however, they do little to detect the immediate molecular/cellular alterations. Therefore, there is an obvious need to develop imaging modalities that detect the initial molecular pathological events. The long-term goal of this project is develop robust non-invasive imaging probes that are capable of detecting neural injury with high sensitivity and specificity. To achieve this goal, the primary objective of this proposal is to validate a non-invasive molecular imaging probe a clinical context. This objective will be realized through the completion of the following two specific aims: 1. Validate non-invasive molecular imaging probe to detect brain injury in a pre-clinical model, 2. Determine efficacy of molecular imaging probe to detect brain injury in human brain tissue. The proposed research is innovative because it explores a mechanism to better characterize the well-known heterogeneity of brain injury pathology. This contribution is significant because the technology developed in this proposal has the potential to revolutionize the precision diagnostics and therapeutics (theranostics) approach for TBI.
Effective start/end date10/1/145/1/17


  • Flinn Foundation: $100,000.00


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