Neuropsychological Functioning and Stress Reactivity in Type 1 Diabetes Mellitus

Project: Research project

Project Details


Neuropsychological Functioning and Stress Reactivity in Type 1 Diabetes Mellitus Neuropsychological Functioning and Stress Reactivity in Type 1 Diabetes Mellitus Type 1 Diabetes Mellitus (T1DM), which involves the inability to produce insulin, is a chronic disease diagnosed in childhood and adolescence. When untreated or mismanaged, T1DM results in numerous immediate and long-term health problems including coma and death. Avoidance of long-term complications requires maintaining tight blood glucose control through complex behavioral and pharmaceutical regimens. Emerging adulthood represents a potentially vulnerable period for individuals with T1DM in that they must assume relatively independent responsibility for their treatment and manage the transition from pediatric to adult care, while also facing other major life stressors. Mild cognitive impairments associated with T1DM and dysregulation of the stress response system are two factors that may partially account for problems negotiating life changes and maintaining treatment adherence among emerging adults. Understanding the impact of stress on cognition in persons with T1DM can help explain how mild cognitive impairments, which may not be readily apparent in low stress situations, may lead to clinically significant impairments during critical high-stress moments of disease management. The current study will examine whether young adults with T1DM physiologically respond to psychological stress in a dysregulated manner compared to non-diabetic peers (e.g. attenuated vs. exaggerated cortisol response), and if such individuals also demonstrate greater cognitive declines in response to psychological stress. Participants will take part in a laboratory-based social stressor, complete pre- and post-stressor neurocognitive testing, and provide finger-stick blood samples (for glucose levels) and salivary samples (for cortisol levels) at five time-points across the protocol. Participants will also complete multiple questionnaires concerning psychosocial factors. Greater insight into these processes has implications for designing and implementing effective interventions that can support a successful transition to young adulthood and inform research and interventions for individuals with diabetes in general.
Effective start/end date1/1/123/31/13


  • American Psychological Association (APA): $1,000.00


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