NANOGLUE COMPOSITES FOR COLORECTAL REPAIR AND REGENRATION NANOGLUE COMPOSITES FOR COLORECTAL REPAIR AND REGENRATION SUMMARY OF THE PROPOSED RESEARCH Over 600,000 people in the United States will undergo surgical procedures to treat serious colorectal diseases. Several patients require end-to-end fusion (anastomoses) of the healthy sections following removal of diseased segments in order to facilitate tissue regeneration. Concerns with anastomoses leakage can cause serious infection leading to death. In the proposed research, we will develop novel nanocomposites (NanoGlue) for laser-based welding of tissues for colorectal anastomoses. Embedding gold nanorods within an elastin-like polypeptide (ELP) matrix results in the formation of the NanoGlue composite. The plasmonic nature of gold nanorods facilitates conversion of laser irradiation to heat, resulting in enhanced tissue temperatures. Elevated temperatures, in concert with temperature-dependent structural changes in the ELP, facilitate the welding or fusion of tissues, leading to fluid-tight sealing. In the proposed research, cellularized and non-cellularized Nanoglue composites will be employed for ex-vivo laser tissue welding leading to anastomosis of porcine intestinal tissue, which will be used as models for colorectal tissues. The tensile strength and leaking or bursting pressures of welded tissues will be determined and compared to traditional suturing methods. Findings from this research will guide testing in larger animal models, and ultimately facilitate translation to human patients for colorectal regeneration and repair following surgery.
|Effective start/end date||1/1/13 → 8/31/15|
- Mayo Clinic Arizona: $40,000.00
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.