Multivariable Models of Brain Structure that Classify Post-Traumatic Headache and Differentiate It from Migraine

Multivariable Models of Brain Structure that Classify Post-Traumatic Headache and Differentiate It from Migraine Multivariable Models of Brain Structure that Classify Post-Traumatic Headache and Differentiate It from Migraine Traumatic brain injury (TBI) and post-traumatic headache (PTH) are common conditions that exert substantial impacts in military and civilian populations. Approximately 1.7 million Americans seek medical attention each year for TBI and there are 1.6-3.8 million sports concussions annually. Headache is the most common symptom following mild TBI (mTBI), with estimates of headache prevalence as high as 90%. A major challenge for the investigation and treatment of PTH is the inability to reliably diagnose PTH and differentiate PTH from migraine. This research will utilize machine-learning techniques to develop diagnostic classifiers based upon structural magnetic resonance imaging data that accurately identify PTH and that differentiate PTH from migraine.