The proposed study is based on a multivalent and cooperative interaction that is a fundamental process underlying the activation, expansion and execution of protective immunity against various targets, including cancers. NK cell-dependent killing of cancer cells can be triggered upon engagement of activators on the NK cells with ligands on the tumor cells, including antibody-dependent cellular cytotoxicity (ADCC)1. Thus, it is conceivable that aptamers, known as chemical antibodies2, can be exploited for ADCC as well, by inducing aptamer-dependent cellular cytotoxicity (ApDCC). For this purpose, NK-specific and tumor specific aptamers can be linked by DNA, which is an ideal scaffolding material, due to its feasibility of being self-assembled into highly ordered structures, according to simple Watson-Crick base pairing 3.
|Effective start/end date||9/15/09 → 1/14/11|
- DOD-ARMY: Army Medical Research Acquisition Activity (USAMRAA) : $98,578.00