Statement of Work Preclinical Alzheimers Disease: MRI Biomarker Discovery with Geometric Methods We will develop and apply novel algorithms to brain MRIs obtained from the well-characterized Arizona APOE cohort of presymptomatic individuals. Our preliminary results have shown, for the first time, statistically significant differences in several brain regions between APOE e4 carriers and non-carriers with either mild cognitive impairment or dementia in the Alzheimers Disease Neuroimaging Initiative (ADNI) dataset. In the current project we will continue develop novel MRI imaging methods using diffusion geometry and hyperbolic conformal geometry. Additionally, we seek to 1) replicate these findings in an independent cohort of Arizona APOE carriers, 2) extend them to younger individuals than those included in the ADNI dataset, and 3) explore additional regions of anatomical interest so as to develop MRI biomarkers for the identification of preclinical stage Alzheimers disease that in turn will facilitate the therapeutic goals of prevention and earlier intervention to retard dementia progression.
|Effective start/end date||7/15/13 → 6/30/16|
- HHS: National Institutes of Health (NIH): $409,038.00