Metabolomics Analysis of Autism-Related Alterations and Connections in Children and Mothers

Project: Research project

Project Details

Description

Metabolomics Analysis of Autism-Related Alterations and Connections in Children and Mothers Metabolomics Analysis of Autism-Related Alterations and Connections in Children and Mothers Our long-term goal is to identify metabolic vulnerabilities induced by autism spectrum disorders (ASD), which will provide innovative and promising opportunities to eventually reduce the ASD threat to human health. We notice that ASD is closely linked to metabolism, and the impact of maternal pregnancy is substantial to ASD during pivotal developmental windows. However, autism-related metabolic alterations and connections in children and their mothers are still largely unknown, which misses precious opportunities to prevent and/or repair ASD before birth. To address this fundamental gap, we will carry out the first metabolomics study to investigative how ASD alters metabolism in both mothers and children. Successful implementation of this multidisciplinary study will lay the foundation for the development of a better understanding of how ASD influences metabolism in mothers and children, as well as their connections. The outcome of our studies will open a new and unique window to prevent and/or repair ASD even before birth, through identifying metabolic vulnerabilities in the ASD-regulated metabolome. To ensure successful completion of the proposed aims, we have assembled an outstanding multidisciplinary team with Dr. Haiwei Gu (PI) focused on mass spectrometry-based metabolomics, and Dr. James B. Adams (co-I) specialized in autism intervention and therapy.
StatusFinished
Effective start/end date6/1/185/31/19

Funding

  • Autism Research Institute: $25,000.00

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