Markers of Inflammation and Lactation Outcomes in Obese Women Markers of Inflammation and Lactation Outcomes in Obese Women Obese mothers stop breastfeeding as much as 6 weeks earlier than non-obese mothers, and are up to 20% less likely to be exclusively breastfeeding at any time point. In addition to psychological and mechanical barriers associated with obesity, evidence from animals points to a physiological barriers. Recent work suggests that obesity-associated inflammation and elevations in proinflammatory cytokines may reduce milk production in obese mothers, resulting in shortened breastfeeding duration. Macrophage infiltration of fat tissue and production of proinflammatory cytokines is a hallmark of obesity. Elevations in proinflammatory cytokines are responsible for much of the disease burden associated with obesity such as insulin resistance, diabetes and even cancer. Despite the potential for an effect on both lactation and child growth, there are no studies of proinflammatory cytokine content in obese lactating women. The goal of this study is to determine the impact of obesity on proinflammatory cytokine content in serum and breastmilk. Through measures of maternal perception of milk volume, breastfeeding duration and exclusivity we will also begin to understand how cytokine balance may contribute to breastfeeding outcomes. The results of this study may lead to interventions to increase breastfeeding by addressing the negative effects of inflammation on milk production.
|Effective start/end date||11/6/13 → 11/1/15|
- INDUSTRY: Domestic Company: $7,000.00
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