Liquid-to-solid gelling polymer system for intracranial aneurysm embolization

Project: Research project

Project Details

Description

Liquid-to-solid gelling polymer system for intracranial aneurysm embolization Liquid-to-solid gelling polymer system for intracranial aneurysm embolization The overarching goal of this project is to develop a novel material for endovascular embolization of intracranial aneurysms. This material is composed of a dual-monomer liquid polymer system that undergoes chemical cross-linking in the presence of a basic solution. For this work, the initiating solution will be composed of a pH-adjusted liquid radio-opaque agent. When the dual-monomer system is mixed with the radio-opaque agent, a reverse emulsion is formed, whereby the radio-opaque agent is dispersed within the continuous monomer phase. This dispersion will provide clinically sufficient fluoroscopic visualization of the material and the means for reaction initiation, after which the material solidifies in a predictable and controllable manner. The advantages of this system include the absence of organic solvents, low tissue adhesiveness, and the ability to fill the entire aneurysm volume. Due to its reaction mechanism, this polymer system does not require formulation with organic solvents, unlike some currently available embolic agents. Furthermore, initial tests have shown that this material is not tissue-adhesive as a liquid, so there is no risk of gluing the catheter tip to tissue upon catheter removal. Finally, the time-dependent nature of solidification will allow this material to conform to the aneurysm shape as it is introduced in liquid form. While this process will require balloon remodeling of the parent artery for containment before solidification, it is advantageous because the entire volume of the aneurysm can be filled. Currently available liquid embolics are often formulated to solidify immediately on contact with blood, making a liquid fill impossible, since the material is already solid as it exits the catheter. There are three main goals to be accomplished in this project. First, incorporation of liquid radio-opaque agents into the polymer system will be performed, with a thorough investigation of how different agents affect the gelling process. Through experimentation with different agents, an optimal material formulation can be determined. The optimal formulation will identify the radio-opaque agent, its level of pH adjustment, and the mixing parameters required to produce a clinically viable material. Second, in vitro cytotoxicity will be examined using direct and indirect cell-based assays. Finally, in vivo biocompatibility and effectiveness will be analyzed using swine and canine aneurysm models.
StatusFinished
Effective start/end date7/1/106/30/11

Funding

  • American Heart Association: Pacific Mountain Affiliate: $24,772.00

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