Investigating the role of Novel Pharmacological Agents to Enhance Recovery Following Brain Injury Investigating the role of Novel Pharmacological Agents to Enhance Recovery Following Brain Injury The proposed studies are directed at testing the efficacy of compounds developed by Dart Neuroscience to enhance functional recovery after stroke. All compounds will be tested using a well established rodent model of cortical ischemia and motor impairment that has been used successfully to study the efficacy of adjuvant therapies to promote rehabilitationdependent motor recovery and cortical plasticity after stroke (Boychuk et al., 2011, MacDonald et al., 2007). The approach combines extensive behavioral and neurophysiological methods that allows for a comprehensive examination of the neural correlates mediating motor improvement post stroke. For all experiments, animals will be trained on a battery of motor tasks to establish baseline measures of motor performance. Animals will then receive cortical infarctions within the forelimb sensorimotor cortex via photothrombosis of lateral and dorsal aspects of the middle cerebral artery. Individual compounds will then be administered in conjunction with daily motor rehabilitation for several weeks and motor performance assessed. Intracortical microstimulation will then be used to derive high resolution motor maps of forelimb movement representations. The efficacy of each compound will then be assessed by comparing the rate and level of motor recovery in drug treated and non treated animals.
|Effective start/end date||9/15/14 → 9/14/15|
- INDUSTRY: Domestic Company: $250,000.00
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